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Gilteritinib (By mouth)

Gilteritinib (gil-te-RI-ti-nib)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to gilteritinib, or if you are pregnant.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take this medicine at the same time each day.
Swallow the tablet whole with water. Do not break, crush, or chew it.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: If you miss a dose and it is less than 12 hours until your next regular dose, skip the missed dose and take your next dose at the regular time. If you miss a dose and it is 12 hours or more until your next dose, take the missed dose then go back to your regular schedule.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some medicines may affect how gilteritinib works. Tell your doctor if you are using cephalexin, escitalopram, fluconazole, fluoxetine, itraconazole, midazolam, rifampin, or sertraline.

This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment with this medicine and for at least 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 4 months after the last dose. Your doctor will give you a pregnancy test within 7 days before you use this medicine to make sure you are not pregnant.
Do not breastfeed during treatment and for at least 2 months after the last dose.
Tell your doctor if you have heart or heart rhythm problems or electrolyte imbalance.
This medicine may cause the following problems:
- Differentiation syndrome, which may be life-threatening
- Posterior reversible encephalopathy syndrome (PRES)
- Heart rhythm problems (including QT prolongation)
- Pancreatitis (swelling of the pancreas)
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Change in how much or how often you urinate
Chest pain, trouble breathing
Fainting, dizziness, lightheadedness
Fast, pounding, or uneven heartbeat
Fever, chills, cough, sore throat, body aches
Numbness, tingling, or burning pain in your hands, arms, legs, or feet
Rapid weight gain, swelling of your arms or legs
Seizures, headache, confusion, vision problems, drowsiness, tiredness or weakness
Sudden and severe stomach pain, nausea, vomiting

Last Updated: 12/4/2023