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Tezacaftor/ivacaftor/ivacaftor (By mouth)

Treats cystic fibrosis.

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to tezacaftor or ivacaftor.

Your doctor will tell you how much medicine to use. Do not use more than directed.
Swallow the tablets whole. Do not crush, break, or chew them.
Take this medicine with food that contains fat, including food prepared with butter or oils, cheese, eggs, meat, nuts, or whole milk. This helps your body absorb the medicine better.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: If it is 6 hours or less from the time you normally take your medicine, take a dose as soon as you can. If it is more than 6 hours, skip the missed dose and take your next dose at the regular time. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Do not use this medicine together with carbamazepine, rifabutin, rifampin, phenobarbital, phenytoin, or St John's wort.
Some medicines may affect how tezacaftor/ivacaftor and ivacaftor works. Tell your doctor if you are using any of the following:
- Clarithromycin, cyclosporine, digoxin, erythromycin, everolimus, fluconazole, glimepiride, glipizide, itraconazole, ketoconazole, posaconazole, sirolimus, tacrolimus, telithromycin, voriconazole
- Blood thinner (including warfarin)
- Steroid medicine
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or if you have ever been exposed to radiation.
This medicine may cause the following problems:
- Liver problems
- Cataracts
This medicine may cause dizziness. Do not drive or do anything else that could be dangerous unless you know how this medicine affects you.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blurred vision, changes in vision
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

Last Updated: 12/4/2023