Emtricitabine/tenofovir alafenamide (By mouth)

Emtricitabine (em-trye-SYE-ta-been), Tenofovir Alafenamide (ten-OF-oh-vir al-a-FEN-a-mide)

Treats HIV infection. HIV causes AIDS. Also used as a part of complete prevention strategy to lower risk of getting HIV infection in patients who are at risk. This medicine does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease.

Brand Name(s):

Descovy

When This Medicine Should Not Be Used:

How to Use This Medicine:

Tablet

• Your doctor will tell you how much medicine to use. Do not use more than directed.
• This medicine is used with other medicines to treat HIV infection. Take all other medicines your doctor has prescribed as part of your combination treatment.
• Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the medicine in the original bottle.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• There are many medicines that can interact with this medicine. Make sure your doctor knows about all other medicines you are using, especially any of the following:
  • Acyclovir, cidofovir, ganciclovir, gentamicin, rifabutin, rifampin, rifapentine, St. John's wort, tipranavir/ritonavir, valacyclovir, or valganciclovir
  • Medicine to treat seizures (including carbamazepine, oxcarbazepine, phenobarbital, phenytoin)
  • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant, or if you have kidney problems, liver disease (including hepatitis B), or bone problems (including osteoporosis).
• Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.
• This medicine may cause the following problems:
  • Lactic acidosis (too much acid in your blood)
  • Liver problems
  • Worsening of hepatitis B infection
  • Kidney problems
  • Lower bone mineral density
• If you are using this medicine for Pre-Exposure prophylaxis: You should be confirmed that you are HIV-negative before you start taking this medicine. You and your partner should be tested regularly (for at least 3 months) for Hive. You should also be tested regularly for other sexually transmitted disease, including syphilis or gonorrhea.
• Your immune system may get stronger when you take HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.
• This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Bone pain
• Change in how much or how often you urinate, cloudy urine
• Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
• Fast breathing, trouble breathing, nausea and vomiting, lightheadedness, severe weakness, tiredness, or confusion

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 12/4/2023