More <

Cobimetinib (By mouth)

Cobimetinib (koe-bi-ME-ti-nib)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to cobimetinib, or if you are pregnant or breastfeeding.

Your doctor will tell you how much medicine to use. Do not use more than directed.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: If you vomit after taking your medicine or miss a dose, take your next regular dose at the next scheduled time. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Some foods and medicines can affect how cobimetinib works. Tell your doctor if you are using carbamazepine, ciprofloxacin, efavirenz, erythromycin, itraconazole, phenytoin, rifampin, or St John's wort.

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use birth control during treatment and for 2 weeks after your last dose.
Do not breastfeed while you are taking this medicine and for 2 weeks after your last dose.
Tell your doctor if you have liver disease, bleeding problems, heart disease, or other skin problems.
Tell your doctor if you have the following problems:
- Increased risk for other cancers (skin and non-skin cancer)
- Increased risk of bleeding
- Heart problems
- Serious skin reactions
- Eye or vision problems
- Liver problems
- Rhabdomyolysis (severe muscle problem)
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blurred vision, vision changes, eye pain, vision changes, sensitivity to light
Chest pain, fast or uneven heartbeat, trouble breathing
Confusion, weakness, and muscle twitching
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Dry mouth, increased thirst, muscle cramps
Muscle pain, tenderness, or weakness
Severe rash, painful itchy skin that is hot to the touch, or thickened dry wrinkled skin
Swelling in your hands, ankles or feet
Unusual bleeding, bruising, or weakness
Warts, skin sores, or reddish bumps that do not heal

Last Updated: 4/23/2024