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Perampanel (By mouth)

Perampanel (per-AM-pa-nel)

There may be other brand names for this medicine.

This medicine is generally considered safe for most people. Talk to your doctor if you have concerns.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. This medicine should be taken at bedtime.
Measure the oral liquid with the bottle adapter and oral syringe provided. Shake the bottle well before each use.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not use extra medicine to make up for a missed dose. Call your doctor if you miss more than one dose of this medicine.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Throw away any unused oral liquid 90 days after the bottle is opened for the first time.

Some foods and medicines can affect how perampanel works. Tell your doctor if you are also using carbamazepine, oxcarbazepine, phenytoin, rifampin, or St John's wort.
Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
Do not drink alcohol while you are using this medicine.

Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or a history of depression, suicidal thoughts, or mood problems.
This medicine may cause the following problems:
- Anger, aggression, hostility, or other mood or behavior changes
- Increased risk of depression or suicidal thoughts
- Increased risk for falls
- Drug reaction with eosinophilia and systemic symptoms (DRESS), which can damage organs including the liver, kidney, or heart
This medicine may make you dizzy, drowsy, unsteady, or less alert. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
Birth control pills that contain levonorgestrel may not work as well while you use this medicine. Use another form of birth control together with your pills during treatment with this medicine and for at least 1 month after the last dose. Talk to your doctor if you have questions.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Depression, nervousness, restlessness, trouble sleeping
Feeling aggressive, angry, hostile, irritable
Swollen, painful, or tender lymph glands in the neck, armpit, or groin, yellow skin or eyes
Trouble walking, speaking, or controlling body movements
Unusual mood or behavior, thoughts of hurting yourself

Last Updated: 12/4/2023