Ibuprofen lysine (By injection)

Ibuprofen Lysine (eye-bue-PROE-fen LYE-seen)

Treats a heart condition known as patent ductus arteriosus (PDA) in premature babies. This drug is an NSAID.

Brand Name(s):

Neoprofen

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. This medicine should not be given if your child has an allergic reaction to ibuprofen lysine, or if your child has congenital heart disease, active bleeding, blood clotting problems, untreated infection, kidney disease, stomach or bowel problems, or thrombocytopenia (low platelets in the blood).

How to Use This Medicine:

Injectable

• A nurse or other trained health professional will give your child this medicine in a hospital. It is given through a needle placed into one of your child's veins. This medicine must be given slowly, so the IV tube will need to stay in place for at least 15 minutes.
• A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines may affect how ibuprofen lysine works. Tell your doctor if your child is also receiving amikacin or diuretics (water pill).

Warnings While Using This Medicine:

• Tell your doctor if your child has any infection or bleeding problems.
• This medicine may cause the following problems:
  • Increased risk of infection
  • Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, and acute generalized exanthematous pustulosis (AGEP)
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, red skin rash
• Change in how much or how often you urinate
• Fever, chills, sore throat, cough, body aches
• Shaking, trembling, sweating, fast or pounding heartbeat, faintness or lightheadedness, hunger, confusion
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 4/23/2024