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Ziprasidone (By mouth)

Ziprasidone (zi-PRAS-i-done)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to ziprasidone.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
It is best to take this medicine with food at the same time every day.
Swallow the capsule whole. Do not break, crush, or chew it.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Do not use this medicine together with amiodarone, arsenic trioxide, chlorpromazine, disopyramide, dofetilide, dolasetron mesylate, droperidol, gatifloxacin, halofantrine, levomethadyl acetate, mefloquine, mesoridazine, moxifloxacin, pentamidine, pimozide, probucol, procainamide, quinidine, sotalol, sparfloxacin, tacrolimus, or thioridazine.
Some medicines can affect how ziprasidone works. Tell your doctor if you are using any of the following:
- Carbamazepine, ketoconazole, levodopa
- Blood pressure medicine
- Diuretic (water pill)

Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, blood or bone marrow problems, diabetes, high cholesterol, trouble swallowing, or a history of seizures or breast cancer. Tell your doctor if you have heart rhythm problems (such as QT prolongation) or any heart or blood vessel problems, including low blood pressure, heart failure, or a history of a heart attack.
This medicine may cause the following problems:
- Heart rhythm problems
- Neuroleptic malignant syndrome (possibly life-threatening neurological disorder)
- Drug reaction with eosinophilia and systemic symptoms (DRESS), which can damage organs such as the liver, kidney, or heart
- Serious skin reactions
- Tardive dyskinesia (trouble controlling muscle movements)
This medicine may make you dizzy or drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures, or other injuries. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel lightheaded or dizzy.
You may get overheated more easily while you are using this medicine. Use caution when you exercise strenuously or are outside in hot weather. Drink plenty of water to stay hydrated.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blistering, peeling, red skin rash
Chills, cough, sore throat, and body aches
Fast, slow, pounding, or uneven heartbeat
Fever, skin rash, or swollen glands in your armpits, neck, or groin
Fever, sweating, confusion, muscle stiffness, seizures
Increased thirst, hunger, or urination
Lightheadedness, dizziness, or fainting
Painful, prolonged erection of your penis
Twitching or muscle movements you cannot control (especially in your face, tongue, or jaw)
Unusual bleeding, bruising, or weakness

Last Updated: 12/4/2023