Alosetron (By mouth)
Treats irritable bowel syndrome (IBS).
LotronexThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. Do not use it if you had an allergic reaction to alosetron, or if you have constipation, a bowel disease (such as a blockage, colitis, Crohn disease, or diverticulitis), or a history of blood clots.
How to Use This Medicine:
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
- This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
- Missed dose: Skip the missed dose and go back to your regular dosing schedule. Do not double doses.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Do not use alosetron if you are also using fluvoxamine.
- Some medicines can affect how alosetron works. Tell your doctor if you are using any of the following:
- Medicine to treat an infection (including clarithromycin, itraconazole, ketoconazole, telithromycin, voriconazole, or a quinolone antibiotic)
- Protease inhibitor medicine to treat HIV infection
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease or other stomach or bowel problems.
- This medicine may cause the following problems:
- Severe constipation
- Ischemic colitis
- Call your doctor if your symptoms do not improve or if they get worse.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- New or worsening stomach pain or cramps
- Red or black stools
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 3/29/2022