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Propylthiouracil (By mouth)

Propylthiouracil (proe-pil-thye-oh-URE-a-sil)

There may be other brand names for this medicine.

You should not use this medicine if you have had an allergic reaction to propylthiouracil, or if you are pregnant or breastfeeding.

Your doctor will tell you how much medicine to use. Do not use more than directed.
It is best to take propylthiouracil at the same time each day. If you take more than one tablet every day, try to take the medicine at evenly spaced intervals, such as every 12 hours if you take it two times a day, or every 8 hours if you take it three times a day.

Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Make sure your doctor knows if you are also using amiodarone (Cordarone®), certain blood pressure medicine (such as atenolol, metoprolol, propranolol, Inderal®, or Toprol®), potassium supplements, a blood thinner (such as warfarin, Coumadin®), theophylline (Theo-Dur®), or digoxin (Lanoxin®).
Talk to your doctor before getting any vaccines (such as flu shots). Also, other people living in your home should not get oral polio vaccine while you are using this medicine. There is a chance they could pass on the polio virus to you.

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
Make sure your doctor knows if you have liver disease.
It may take several days or weeks for propylthiouracil to start working. Do not stop using the medicine without talking to your doctor.
This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
Liver problems may occur with this medicine. Stop using this medicine and check with your doctor right away if you are having more than one of these symptoms: right upper abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.
Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. Blood tests may be needed to check for unwanted effects.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Changes in menstrual periods.
Cough or sore throat.
Dark-colored urine or pale stools.
Dry, puffy skin.
Mouth sores.
Nausea, vomiting, loss of appetite, or pain in your upper stomach.
Severe fever or chills, or fever that lasts longer than 2 days.
Skin rash or itching.
Swelling in your neck (thyroid).
Unexplained bleeding or bruising.
Unusual weakness.
Yellowing of your skin or the whites of your eyes.

Last Updated: 12/4/2023