Browse A-Z

More <
bookmarks-menu

Paroxetine (By mouth)

Paroxetine (par-OX-e-teen)

Treats depression, anxiety disorders, obsessive-compulsive disorder (OCD), and premenstrual dysphoric disorder (PMDD). Brisdelle® treats hot flashes caused by menopause. This medicine is an SSRI.

Brand Name(s):

Brisdelle, Paxil, Paxil CR, Pexeva

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to paroxetine, or if you are pregnant.

How to Use This Medicine:

Capsule, Liquid, Tablet, Long Acting Tablet

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Oral liquid, Tablet, Extended-release Tablet: These are usually taken in the morning.
  • Brisdelle® capsule: Take at bedtime.
  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup. Shake the bottle well just before you measure each dose.
  • Tablet or Extended-release Tablet: Swallow whole. Do not crush, break, or chew it. Do not use an extended-release tablet that is cracked or chipped.
  • You may need to take this medicine for a month or longer before you feel better. If you feel that the medicine is not working well, do not take more than your normal dose. Call your doctor for instructions.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use paroxetine and an MAO inhibitor (including isocarboxazid, linezolid, methylene blue, phenelzine, selegiline, tranylcypromine) within 14 days of each other. Do not use this medicine if you are using pimozide or thioridazine.
  • Some medicines can affect how paroxetine works. Tell your doctor if you are using any of the following:
    • Amitriptyline, atomoxetine, cimetidine, dextromethorphan, digoxin, fentanyl, fosamprenavir/ritonavir, meperidine, methadone, metoprolol, nebivolol, phenobarbital, phenytoin, procyclidine, risperidone, St John's wort, tamoxifen, theophylline, tolterodine, tramadol
    • Amphetamines
    • Blood thinner (including clopidogrel, heparin, warfarin)
    • Diuretic (water pill)
    • Medicine for heart rhythm problems (including encainide, flecainide, propafenone, quinidine)
    • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)
    • Other medicine for depression or anxiety (including buspirone, desipramine, fluoxetine, imipramine, lithium, nortriptyline, venlafaxine)
    • Phenothiazine medicine (including chlorpromazine, perphenazine, prochlorperazine, promethazine)
    • Triptan medicine for migraine headaches
    • Tryptophan supplements
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, glaucoma, or a history of epilepsy or seizures.
  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
  • This medicine may cause the following problems:
    • Serotonin syndrome (may be life-threatening when used with certain other medicines)
    • Increased risk of bleeding problems
    • Increased risk of broken bones
    • Sexual problems
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
  • This medicine may decrease the amount of sperm men make and affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
  • Bone pain, tenderness, swelling, or bruising
  • Changes in behavior, thoughts of hurting yourself or others
  • Confusion, weakness, muscle twitching
  • Eye pain, vision changes, seeing halos around lights
  • Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
  • Trouble keeping still, feeling restless and agitated, racing thoughts, excessive energy, trouble sleeping
  • Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision, headache, dizziness, drowsiness, sleepiness
  • Constipation, upset stomach, loss of appetite, weight loss
  • Dry mouth
  • Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 12/4/2023

 

 
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language.

© Copyright Merative . All rights reserved