Browse A-Z A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9 Splenomegaly Back Splenomegaly Splenomegaly is an enlargement of the spleen. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Content is best viewed in IE9 or above, Firefox and Google Chrome browser.