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DTaP (diphtheria, tetanus, and pertussis) vaccine - what you need to know

All content below is taken in its entirety from the CDC DTaP (Diphtheria, Tetanus, and Pertussis) Vaccine Information Statement (VIS):

CDC review information for Diphtheria, Tetanus, and Pertussis (DTaP) VIS:

  • Page last reviewed: August 24, 2018
  • Page last updated: August 24, 2018
  • Issue date of VIS: August 24, 2018 

Content source: National Center for Immunization and Respiratory Diseases



DTaP vaccine can help protect your child from diphtheria, tetanus, and pertussis.

  • Diphtheria (D) can cause breathing problems, paralysis, and heart failure. Before vaccines, diphtheria killed tens of thousands of children every year in the United States.
  • Tetanus (T) causes painful tightening of the muscles. It can cause "locking" of the jaw so you cannot open your mouth or swallow. About 1 person out of 5 who get tetanus dies.
  • Pertussis (aP), also known as whooping cough, causes coughing spells so bad that it is hard for infants and children to eat, drink, or breathe. It can cause pneumonia, seizures, brain damage, or death.

Most children who are vaccinated with DTaP will be protected throughout childhood. Many more children would get these diseases if we stopped vaccinating.


Children should usually get 5 doses of DTaP vaccine, one dose at each of the following ages:

  • 2 months
  • 4 months
  • 6 months
  • 15 to 18 months
  • 4 to 6 years

DTaP may be given at the same time as other vaccines. Also, sometimes a child can receive DTaP together with one or more other vaccines in a single shot.


DTaP is only for children younger than 7 years old. DTaP vaccine is not appropriate for everyone - a small number of children should receive a different vaccine that contains only diphtheria and tetanus instead of DTaP.

Tell your health care provider if your child:

  • Has had an allergic reaction after a previous dose of DTaP, or has any severe, life-threatening allergies.
  • Has had a coma or long repeated seizures within 7 days after a dose of DTaP.
  • Has seizures or another nervous system problem.
  • Has had a condition called Guillain-Barré Syndrome (GBS).
  • Has had severe pain or swelling after a previous dose of DTaP or DT vaccine.

In some cases, your health care provider may decide to postpone your child's DTaP vaccination to a future visit.

Children with minor illnesses, such as a cold, may be vaccinated. Children who are moderately or severely ill should usually wait until they recover before getting DTaP vaccine.

Your health care provider can give you more information.


  • Redness, soreness, swelling, and tenderness where the shot is given are common after DTaP.
  • Fever, fussiness, tiredness, poor appetite, and vomiting sometimes happen 1 to 3 days after DTaP vaccination.
  • More serious reactions, such as seizures, non-stop crying for 3 hours or more, or high fever (over 105°F or 40.5°C) after DTaP vaccination happen much less often. Rarely, the vaccine is followed by swelling of the entire arm or leg, especially in older children when they receive their fourth or fifth dose.
  • Long-term seizures, coma, lowered consciousness, or permanent brain damage happen extremely rarely after DTaP vaccination.

As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death.


An allergic reaction could occur after the child leaves the clinic. If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 911 and get the child to the nearest hospital.

For other signs that concern you, call your child's health care provider.

Serious reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). Your doctor will usually file this report, or you can do it yourself. Visit the VAERS website or call 1-800-822-7967. VAERS is only for reporting reactions, it does not give medical advice


The National Vaccine Injury Compensation Program (VICP) is a federal program that was created to compensate people who may have been injured by certain vaccines.

Visit the VICP website or call 1-800-338-2382 to learn about the program and about filing a claim. There is a time limit to file a claim for compensation..


Contact the Centers for Disease Control and Prevention (CDC):


Centers for Disease Control and Prevention website. DTaP vaccine (diphtheria, tetanus, and pertussis). Vaccine Information Statement (VIS). Updated August 24, 2018. Accessed August 28, 2018.

        A Closer Look



        Review Date: 8/28/2018

        Reviewed By: David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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