More <
bookmarks-menu

Tests for H pylori

Show Alternative Names
Peptic ulcer disease - H pylori
PUD - H pylori

Helicobacter pylori (H pylori) is the bacteria (germ) responsible for most stomach (gastric) and duodenal ulcers and many cases of stomach inflammation (chronic gastritis).

How the Test is Performed

There are several methods to test for H pylori infection.

Breath Test (Carbon Isotope-urea Breath Test, or UBT)

  • Up to 2 weeks before the test, you need to stop taking antibiotics, bismuth medicines such as Pepto-Bismol, and proton pump inhibitors (PPIs).
  • During the test, you swallow a special substance that has urea. Urea is a waste product the body produces as it breaks down protein. The urea used in the test has been made harmlessly radioactive.
  • If H pylori are present, the bacteria convert the urea into carbon dioxide, which is detected and recorded in your exhaled breath after 10 minutes.
  • This test can identify almost all people who have H pylori. It can also be used to check that the infection has been fully treated.

Blood Tests

  • Blood tests are used to measure antibodies to H pylori. Antibodies are proteins made by the body's immune system when it detects harmful substances such as bacteria.
  • Blood tests for H pylori can only tell if your body has H pylori antibodies. It cannot tell if you have a current infection or how long you have had it. This is because the test can be positive for years, even if the infection is cured. As a result, blood tests cannot be used to see if the infection has been cured after treatment.

Stool Test

  • A stool test can detect traces of H pylori in the feces.
  • This test can be used to diagnose the infection and confirm that it has been cured after treatment.

Biopsy

  • A tissue sample, called a biopsy, is taken from the stomach lining. This is the most accurate way to tell if you have an H pylori infection.
  • To remove the tissue sample, you have a procedure called esophagogastroduodenoscopy (EGD). The procedure is done in the hospital or outpatient center.
  • Usually, a biopsy is done if EGD is needed for other reasons. Reasons include diagnosing the ulcer, treating bleeding, or making sure there is no cancer.

Why the Test is Performed

Testing is most often done to diagnose H pylori infection:

  • If you currently have a stomach or duodenal ulcer
  • If you had a stomach or duodenal ulcer in the past, and were never tested for H pylori
  • After treatment for H pylori infection, to make sure there are no more of these bacteria

Testing may also be done if you need to take long-term ibuprofen or other NSAID medicines. Your health care provider can tell you more.

The test may also be recommended for a condition called dyspepsia (indigestion). This is upper abdominal discomfort. Symptoms include a feeling of fullness or of heat, burning, or pain in the area between the navel and the lower part of the breastbone during or after eating. Testing for H pylori without EGD is most often done only when the discomfort is new, the person is younger than 55, and there are no other symptoms.

Normal Results

Normal results mean there is no sign that you have an H pylori infection.

What Abnormal Results Mean

Abnormal results mean that you have an H pylori infection. Your provider will discuss treatment with you.

Review Date: 8/7/2023

Reviewed By

Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

References

Cover TL, Blaser MJ. Helicobacter pylori and other gastric Helicobacter species. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 217.

Siddiqi HA, Rabinowitz S, Axiotis CA. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 23.

Disclaimer

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

##RemoveMe##
 

Stomach ulcer - Animation

Food enters the stomach from the esophagus. There, it's broken down by the acid and various enzymes the stomach produces so its nutrients can be absorbed in the small intestine. The inside wall of the stomach is protected from the acid and enzymes by a mucous lining.

Ulcers come about as a result of an imbalance between the stomach's digestive juices and the factors that protect its lining.

Symptoms can include bleeding. And on rare occasions, an ulcer may completely erode the stomach wall.

The bacteria Helicobacter pylori is a major cause of ulcers. Treatment typically includes medications to suppress the stomach acid and antibiotics to eradicate the infection.

 

Peptic ulcer - Animation

If you've got stomach pain and nausea, any number of gastrointestinal problems could be to blame. When these symptoms don't go away, one possibility is that you have a peptic ulcer. Let's talk about peptic ulcers.

A peptic ulcer is a defect in the lining of your stomach or the first part of your small intestine, the duodenum. When the defect is in your stomach, it's called a gastric ulcer. A defect in your duodenum is called a duodenal ulcer.

Your stomach is filled with strong acid, which breaks down and digests the foods you eat. If you've ever seen a strong acid at work, you know that it starts to burn away anything it touches. That's why your stomach and intestines are equipped with a special lining to protect them. But if that lining breaks down for any reason, acids can start eating their way through. When acids burn a hole all the way through the stomach or duodenum, it's called a perforation, and that's a medical emergency.

You may joke that your boss is giving you an ulcer, and it's possible that stress does play some part in ulcers. More likely, your ulcer is caused by a stomach infection with a type of bacteria called H. pylori. Other common ulcer risks include smoking cigarettes, drinking a lot of alcohol, or regularly using NSAID pain relievers like aspirin and ibuprofen.

If the ulcer is small, you may have no idea that you have it because there are no symptoms. Larger ulcers can cause abdominal pain, a feeling of fullness in the stomach, and nausea.

If you have any of these ongoing symptoms, your doctor will look inside your GI tract to see what's going on. One way to do this is with an upper endoscopy, a thin tube with a camera on one end that takes pictures as it moves through your stomach and small intestine. An upper GI is a series of x-rays that are taken after you drink a substance called barium. Your doctor will also test you for the H. pylori bacteria that may be causing your ulcer.

Treatment for peptic ulcers works in two ways. If you have an H. pylori infection, you'll have a medication regimen to kill the bacteria. You'll also get a medicine called a proton pump inhibitor, such as Prilosec or Prevacid, which reduces the amount of acid in your stomach.

Try to avoid taking NSAID pain relievers for long periods of time, especially if you have a problem with H. pylori. Use Tylenol instead. If you do have to take NSAIDs, also take an acid-blocking drug to protect your sensitive stomach. Also avoid tobacco smoke and excess alcohol.

Follow your doctor's instructions carefully for treating a peptic ulcer. If you don't follow your treatment as directed, your ulcer could easily come back. Call your doctor right away if you have sharp stomach pain, if you're sweating a lot or feeling confused, or your stomach feels hard to the touch. These could be signs of a serious ulcer complication that needs immediate medical help.

 

Stomach ulcer - Animation

Food enters the stomach from the esophagus. There, it's broken down by the acid and various enzymes the stomach produces so its nutrients can be absorbed in the small intestine. The inside wall of the stomach is protected from the acid and enzymes by a mucous lining.

Ulcers come about as a result of an imbalance between the stomach's digestive juices and the factors that protect its lining.

Symptoms can include bleeding. And on rare occasions, an ulcer may completely erode the stomach wall.

The bacteria Helicobacter pylori is a major cause of ulcers. Treatment typically includes medications to suppress the stomach acid and antibiotics to eradicate the infection.

 

Peptic ulcer - Animation

If you've got stomach pain and nausea, any number of gastrointestinal problems could be to blame. When these symptoms don't go away, one possibility is that you have a peptic ulcer. Let's talk about peptic ulcers.

A peptic ulcer is a defect in the lining of your stomach or the first part of your small intestine, the duodenum. When the defect is in your stomach, it's called a gastric ulcer. A defect in your duodenum is called a duodenal ulcer.

Your stomach is filled with strong acid, which breaks down and digests the foods you eat. If you've ever seen a strong acid at work, you know that it starts to burn away anything it touches. That's why your stomach and intestines are equipped with a special lining to protect them. But if that lining breaks down for any reason, acids can start eating their way through. When acids burn a hole all the way through the stomach or duodenum, it's called a perforation, and that's a medical emergency.

You may joke that your boss is giving you an ulcer, and it's possible that stress does play some part in ulcers. More likely, your ulcer is caused by a stomach infection with a type of bacteria called H. pylori. Other common ulcer risks include smoking cigarettes, drinking a lot of alcohol, or regularly using NSAID pain relievers like aspirin and ibuprofen.

If the ulcer is small, you may have no idea that you have it because there are no symptoms. Larger ulcers can cause abdominal pain, a feeling of fullness in the stomach, and nausea.

If you have any of these ongoing symptoms, your doctor will look inside your GI tract to see what's going on. One way to do this is with an upper endoscopy, a thin tube with a camera on one end that takes pictures as it moves through your stomach and small intestine. An upper GI is a series of x-rays that are taken after you drink a substance called barium. Your doctor will also test you for the H. pylori bacteria that may be causing your ulcer.

Treatment for peptic ulcers works in two ways. If you have an H. pylori infection, you'll have a medication regimen to kill the bacteria. You'll also get a medicine called a proton pump inhibitor, such as Prilosec or Prevacid, which reduces the amount of acid in your stomach.

Try to avoid taking NSAID pain relievers for long periods of time, especially if you have a problem with H. pylori. Use Tylenol instead. If you do have to take NSAIDs, also take an acid-blocking drug to protect your sensitive stomach. Also avoid tobacco smoke and excess alcohol.

Follow your doctor's instructions carefully for treating a peptic ulcer. If you don't follow your treatment as directed, your ulcer could easily come back. Call your doctor right away if you have sharp stomach pain, if you're sweating a lot or feeling confused, or your stomach feels hard to the touch. These could be signs of a serious ulcer complication that needs immediate medical help.

 
 
 
 

 

 
 

 
© 1997-ADAM Company Logo All rights reserved.