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Creatinine clearance test

Serum creatinine clearance; Kidney function - creatinine clearance; Renal function - creatinine clearance

The creatinine clearance test helps provide information about how well the kidneys are working. The test compares the creatinine level in urine with the creatinine level in blood.

How the Test is Performed

This test requires both a urine sample and blood sample. You will collect your urine for 24 hours and then have blood taken. Follow instructions exactly. This ensures accurate results.

How to Prepare for the Test

Your health care provider may ask you to temporarily stop any medicines that may affect the test results. These include some antibiotics and stomach acid medicines. Be sure to tell your provider about all the medicines you take.

DO NOT stop taking any medicine before talking to your provider.

How the Test will Feel

The urine test involves only normal urination. There is no discomfort.

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

Why the Test is Performed

Creatinine is a chemical waste product of creatine. Creatine is a chemical the body makes to supply energy, mainly to muscles.

By comparing the creatinine level in urine with the creatinine level in blood, the creatinine clearance test estimates the glomerular filtration rate (GFR). GFR is a measure of how well the kidneys are working, especially the kidneys' filtering units. These filtering units are called glomeruli.

Creatinine is removed, or cleared, from the body entirely by the kidneys. If kidney function is abnormal, creatinine level increases in the blood because less creatinine is excreted through the urine.

Normal Results

Clearance is often measured as milliliters per minute (mL/min) or milliliters per second (mL/s). Normal values are:

  • Male: 97 to 137 mL/min (1.65 to 2.33 mL/s).
  • Female: 88 to 128 mL/min (14.96 to 2.18 mL/s).

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor to know about the meaning of your specific test results.

What Abnormal Results Mean

Abnormal results (lower than normal creatinine clearance) may indicate:

Risks

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight, but may include:

  • Excessive bleeding
  • Fainting or feeling lightheaded
  • Multiple punctures to locate veins
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)

References

Landry DW, Bazari H. Approach to the patient with renal disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 106.

Oh MS, Briefel G. Evaluation of renal function, water, electrolytes, and acid-base balance. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 14.

  • Creatinine tests

    Creatinine tests - illustration

    A measurement of the serum creatinine level is often used to evaluate kidney function. Urine creatinine levels can be used as a screening test to evaluate kidney function, or can be part of the creatinine clearance test.

    Creatinine tests

    illustration

    • Creatinine tests

      Creatinine tests - illustration

      A measurement of the serum creatinine level is often used to evaluate kidney function. Urine creatinine levels can be used as a screening test to evaluate kidney function, or can be part of the creatinine clearance test.

      Creatinine tests

      illustration

    Tests for Creatinine clearance test

     
     

    Review Date: 7/7/2019

    Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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