BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuCoccidioides complement fixationCoccidioides antibody test; Coccidioidomycosis blood testCoccidioides complement fixation is a blood test that looks for substances (proteins) called antibodies, which are produced by the body in reaction to the fungus Coccidioides immitis. This fungus causes the disease coccidioidomycosis.AntibodiesAn antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include micr...ImageRead Article Now Book Mark Article CoccidioidomycosisValley fever is an infection that occurs when the spores of the fungus Coccidioides immitis enter your body through the lungs.ImageRead Article Now Book Mark Article How the Test is Performed A blood sample is needed.Blood sample is neededVenipuncture is the collection of blood from a vein. It is most often done for laboratory testing.ImageRead Article Now Book Mark Article How to Prepare for the Test There is no special preparation for the test. How the Test will Feel When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging. Afterward, there may be some throbbing. Why the Test is Performed This test is used to detect infection with the fungus that causes coccidioidomycosis, or Valley fever. This condition can cause lung (localized) or widespread (disseminated) infection. Normal Results A normal result means no Coccidioides immitis antibodies are detected in the blood sample.Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your health care provider about the meaning of your specific test results. What Abnormal Results Mean Abnormal results mean that Coccidioides immitis antibodies are present. This can mean that you have a current or past infection.The test may be repeated after several weeks to detect a rise in titer (antibody concentration), which confirms an active infection.TiterA titer is a measurement of the amount or concentration of a substance in a solution. It usually refers to the amount of antibodies found in a perso...Read Article Now Book Mark Article In general, the worse the infection, the higher is the titer, except in people with a weakened immune system.There can be false positive tests in people with other fungal diseases such as histoplasmosis and blastomycosis, and false negative tests in people with single lung masses from coccidioidomycosis.HistoplasmosisHistoplasmosis is an infection that occurs from breathing in the spores of the fungus Histoplasma capsulatum.ImageRead Article Now Book Mark Article BlastomycosisBlastomycosis is an infection caused by breathing in the Blastomyces dermatitidis fungus. The fungus is found in decaying wood and soil.ImageRead Article Now Book Mark Article Risks There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight, but may include:Excessive bleeding Fainting or feeling lightheaded Multiple punctures to locate veins Hematoma (blood accumulating under the skin) Infection (a slight risk any time the skin is broken) Open ReferencesReferencesGalgiani JN. Coccidioidomycosis (Coccidioides species). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 265.Iwen PC, Thompson GR, Wiederhold NP. Mycotic diseases. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 60.AllVideoImagesTogBlood test - illustration Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.Blood testillustrationBlood test - illustration Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.Blood testillustration Tests for Coccidioides complement fixation Coccidioides complement fixationCSF coccidioides complement fixation testRelated Information Antibody(Special Topic)Valley fever(Condition)Titer(Special Topic) Review Date: 8/26/2023 Reviewed By: Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited. © 1997- All rights reserved. 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Coccidioides complement fixationCoccidioides antibody test; Coccidioidomycosis blood testCoccidioides complement fixation is a blood test that looks for substances (proteins) called antibodies, which are produced by the body in reaction to the fungus Coccidioides immitis. This fungus causes the disease coccidioidomycosis.AntibodiesAn antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include micr...ImageRead Article Now Book Mark Article CoccidioidomycosisValley fever is an infection that occurs when the spores of the fungus Coccidioides immitis enter your body through the lungs.ImageRead Article Now Book Mark Article How the Test is Performed A blood sample is needed.Blood sample is neededVenipuncture is the collection of blood from a vein. It is most often done for laboratory testing.ImageRead Article Now Book Mark Article How to Prepare for the Test There is no special preparation for the test. How the Test will Feel When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging. Afterward, there may be some throbbing. Why the Test is Performed This test is used to detect infection with the fungus that causes coccidioidomycosis, or Valley fever. This condition can cause lung (localized) or widespread (disseminated) infection. Normal Results A normal result means no Coccidioides immitis antibodies are detected in the blood sample.Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your health care provider about the meaning of your specific test results. What Abnormal Results Mean Abnormal results mean that Coccidioides immitis antibodies are present. This can mean that you have a current or past infection.The test may be repeated after several weeks to detect a rise in titer (antibody concentration), which confirms an active infection.TiterA titer is a measurement of the amount or concentration of a substance in a solution. It usually refers to the amount of antibodies found in a perso...Read Article Now Book Mark Article In general, the worse the infection, the higher is the titer, except in people with a weakened immune system.There can be false positive tests in people with other fungal diseases such as histoplasmosis and blastomycosis, and false negative tests in people with single lung masses from coccidioidomycosis.HistoplasmosisHistoplasmosis is an infection that occurs from breathing in the spores of the fungus Histoplasma capsulatum.ImageRead Article Now Book Mark Article BlastomycosisBlastomycosis is an infection caused by breathing in the Blastomyces dermatitidis fungus. The fungus is found in decaying wood and soil.ImageRead Article Now Book Mark Article Risks There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight, but may include:Excessive bleeding Fainting or feeling lightheaded Multiple punctures to locate veins Hematoma (blood accumulating under the skin) Infection (a slight risk any time the skin is broken) Open ReferencesReferencesGalgiani JN. Coccidioidomycosis (Coccidioides species). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 265.Iwen PC, Thompson GR, Wiederhold NP. Mycotic diseases. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 60.