Bilirubin blood test
Total bilirubin - blood; Unconjugated bilirubin - blood; Indirect bilirubin - blood; Conjugated bilirubin - blood; Direct bilirubin - blood; Jaundice - bilirubin blood test; Hyperbilirubinemia - bilirubin blood testThe bilirubin blood test measures the level of bilirubin in the blood. Bilirubin is a yellowish pigment found in bile, a fluid made by the liver.
Bilirubin can also be measured with a urine test.
Urine test
Bilirubin is a yellowish pigment found in bile, which is a fluid produced by the liver and stored in the gallbladder. This article is about a lab tes...
Read Article Now Book Mark ArticleHow the Test is Performed
A blood sample is needed.
Blood sample
Venipuncture is the collection of blood from a vein. It is most often done for laboratory testing.
Read Article Now Book Mark ArticleHow to Prepare for the Test
You should not eat or drink for at least 4 hours before the test. Your health care provider may instruct you to stop taking medicines that affect the test.
Many drugs may change the bilirubin level in your blood. Make sure your provider knows which medicines you are taking.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Why the Test is Performed
A small amount of older red blood cells are replaced by new blood cells every day. Bilirubin is left in the blood after these older blood cells are removed. The liver helps break down bilirubin so that it can be removed from the body in the stool.
A level of bilirubin in the blood of 2.0 mg/dL can create jaundice. Jaundice is a yellow color in the skin, mucus membranes, or eyes.
Jaundice
Jaundice is a yellow color of the skin, mucus membranes, or eyes. The yellow coloring comes from bilirubin, a byproduct of old red blood cells. Jau...
Read Article Now Book Mark ArticleJaundice is the most common reason to check bilirubin level. The test will likely be ordered when:
- The provider is concerned about a newborn's jaundice (most newborns have some jaundice)
- Jaundice develops in older infants, children, and adults
A bilirubin test is also ordered when the provider suspects a person has liver or gallbladder problems.
Normal Results
It is normal to have some bilirubin in the blood. A normal level is:
- Direct (also called conjugated) bilirubin: less than 0.3 mg/dL (less than 5.1 µmol/L)
- Total bilirubin: 0.1 to 1.2 mg/dL (1.71 to 20.5 µmol/L)
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different samples. Talk to your provider about the meaning of your specific test results.
What Abnormal Results Mean
In newborns, bilirubin level is higher for the first few days of life. Your child's provider must consider the following when deciding whether your baby's bilirubin level is too high:
- How fast the level has been rising
- Whether the baby was born early
- The baby's age
Jaundice can also occur when more red blood cells than normal are broken down. This can be caused by:
- A blood disorder called erythroblastosis fetalis
Erythroblastosis fetalis
Hemolytic disease of the newborn (HDN) is a blood disorder in a fetus or newborn infant. In some infants, it can be fatal. Normally, red blood cells...
Read Article Now Book Mark Article - A red blood cell disorder called hemolytic anemia
Hemolytic anemia
Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues. Normally, red ...
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Transfusion reaction in which red blood cells that were given in a transfusion are destroyed by the person's immune system
Transfusion reaction
A hemolytic transfusion reaction is a serious complication that can occur after a blood transfusion. The reaction occurs when the red blood cells th...
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The following liver problems may also cause jaundice or a high bilirubin level:
- Scarring of the liver (cirrhosis)
Cirrhosis
Cirrhosis is scarring of the liver and poor liver function. It is the last stage of chronic liver disease.
Read Article Now Book Mark Article - Swollen and inflamed liver (hepatitis)
- Other liver disease
- Disorder in which bilirubin is not processed normally by the liver (for example, Gilbert disease)
Gilbert disease
Gilbert syndrome is a common disorder passed down through families. It affects the way bilirubin is processed by the liver, and may cause the skin t...
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The following problems with gallbladder or bile ducts may cause higher bilirubin levels:
- Abnormal narrowing of the common bile duct (biliary stricture)
Biliary stricture
A bile duct stricture is an abnormal narrowing, most often of the common bile duct. This is a tube that moves bile from the liver to the small intes...
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Cancer of the pancreas or gallbladder
Cancer of the pancreas
Pancreatic cancer is cancer that starts in the pancreas.
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Gallstones
Gallstones
Gallstones are hard deposits that form inside the gallbladder. These may be as small as a grain of sand or as large as a golf ball.
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Risks
There is little risk involved with having your blood taken. Veins vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Risks associated with having blood drawn are slight, but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Multiple punctures to locate veins
- Hematoma (blood collecting under the skin)
- Infection (a slight risk any time the skin is broken)
References
Daniels L, Khalili M, Goldstein E, Bluth MH, Bowne WB, Pincus MR. Evaluation of liver function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 22.
Pratt DS. Liver chemistry and function tests. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 73.
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Blood test - illustration
Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.
Blood test
illustration
-
Blood test - illustration
Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.
Blood test
illustration
Review Date: 2/28/2023
Reviewed By: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.