Opioid intoxication
Intoxication - opioids; Opioid abuse - intoxication; Opioid use - intoxicationOpioid-based drugs include morphine, oxycodone, and synthetic (man-made) opioid narcotics, such as fentanyl. They are prescribed to treat pain after surgery or a dental procedure. Sometimes, they are used to treat severe cough or diarrhea. The illegal drug heroin is also an opioid. When abused, opioids cause a person to feel relaxed and intensely happy (euphoria). In short, the drugs are used to get high.
Abused
When a medicine is not taken in the way it is meant to be used and a person is addicted to it, the problem is called prescription drug use disorder. ...
Read Article Now Book Mark ArticleOpioid intoxication is a condition in which you're not only high from using the drug, but you also have body-wide symptoms that can make you ill and impaired.
Causes
Opioid intoxication may occur when a health care provider prescribes an opioid, but:
- The provider doesn't know the person is already taking another opioid at home.
- The person has a health problem, such as a liver or kidney problem, that may easily result in intoxication.
- The provider prescribes a sleep medicine (sedative) in addition to the opioid.
- The provider doesn't know that another provider already prescribed an opioid.
In people who use opioids to get high, intoxication may be caused by:
- Using too much of the drug
- Using an opioid with certain other drugs, such as sleep medicine or alcohol
- Taking the opioid in ways not normally used, such as smoked or inhaled through the nose (snorted)
Symptoms
Symptoms depend on how much of the drug is taken.
Symptoms of opioid intoxication can include:
- Altered mental status, such as confusion, delirium, or decreased awareness or responsiveness
Delirium
Delirium is sudden severe confusion due to rapid changes in brain function that can occur with physical or mental illness.
Read Article Now Book Mark Article - Breathing problems (breathing may slow and eventually stop)
- Extreme sleepiness or loss of alertness
- Nausea and vomiting
- Small pupils
Exams and Tests
Tests that are ordered depend on the provider's concern for additional medical problems. Tests may include:
- Blood tests
-
CT scan of the brain, if the person is having seizures or might have a head injury
CT scan of the brain
A head computed tomography (CT) scan uses many x-rays to create pictures of the head, including the skull, brain, eye sockets, and sinuses.
Read Article Now Book Mark Article - ECG (electrocardiogram) to measure electrical activity in the heart
Electrocardiogram
An electrocardiogram (ECG) is a test that records the electrical activity of the heart.
Read Article Now Book Mark Article -
Chest x-ray to check for pneumonia
Chest x-ray
A chest x-ray is an x-ray of the chest, lungs, heart, large arteries, ribs, and diaphragm.
Read Article Now Book Mark Article - Toxicology (poison) screening
Treatment
The provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated as appropriate. The person may receive:
- Breathing support, including oxygen, or a tube that goes through the mouth into the lungs and attachment to a breathing machine
Breathing machine
A ventilator is a machine that breathes for you or helps you breathe. It is also called a breathing machine or respirator. The ventilator: Is attac...
Read Article Now Book Mark Article - IV (fluids given through a vein)
- Medicine called naloxone (Evzio, Narcan) to block the effect of the opioid on the central nervous system
- Other medicines as needed
Since the effect of the naloxone is often short, the health care team will monitor the patient for 4 to 6 hours in the emergency department. People with moderate to severe intoxications will likely be admitted to the hospital for 24 to 48 hours.
A mental health evaluation is needed if the person is suicidal.
Outlook (Prognosis)
Many factors determine the short- and long-term outcome after opioid intoxication. Some of these are:
- The degree of poisoning, for example, if the person stopped breathing, and for how long
- How often the drugs are used
- Effect of impurities mixed in with illegal substances
- Injuries that occur as a result of the drug use
- Underlying medical conditions
Possible Complications
Health problems that may occur include any of the following:
- Permanent lung damage
-
Seizures, tremors
Seizures
A seizure is the physical changes in behavior that occurs during an episode of specific types of abnormal electrical activity in the brain. The term ...
Read Article Now Book Mark Article - Reduced ability to think clearly
- Unsteadiness and difficulty walking
- Infections or even permanent damage of the organs as a result of injection use of the drug
References
Aronson JK. Opioid receptor agonists. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:348-380.
National Institute on Drug Abuse website. Opioids. nida.nih.gov/research-topics/opioids. Accessed April 18, 2023.
National Institute on Drug Abuse website. What are the medical complications of chronic heroin use? nida.nih.gov/publications/research-reports/heroin/what-are-medical-complications-chronic-heroin-use. Updated June 2018. Accessed April 18, 2023.
Nikolaides JK, Thompson TM. Opioids. In: Walls RM, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 151.
Review Date: 4/1/2023
Reviewed By: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.