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Migraine

Headache - migraine; Vascular headache - migraine

A migraine is a type of headache. It may occur with symptoms such as nausea, vomiting, or sensitivity to light and sound. In many people, a throbbing pain is felt only on one side of the head.

Causes

A migraine headache is caused by abnormal brain activity. This activity can be triggered by many things. But the exact chain of events remains unclear. Most medical experts believe the attack begins in the brain and involves nerve pathways and chemicals. The changes affect blood flow in the brain and surrounding tissues.

Migraine headaches tend to first appear between the ages of 10 and 45. Sometimes, they begin earlier or later. Migraines may run in families. Migraines occur more often in women than men. Some women, but not all, have fewer migraines when they are pregnant.

Migraine attacks may be triggered by any of the following:

  • Caffeine withdrawal
  • Changes in hormone levels during a woman's menstrual cycle or with the use of birth control pills
  • Changes in sleep patterns, such as not getting enough sleep
  • Drinking alcohol
  • Exercise or other physical stress
  • Loud noises or bright lights
  • Missed meals
  • Odors or perfumes
  • Smoking or exposure to smoke
  • Stress and anxiety

Migraines can also be triggered by certain foods. Most common are:

  • Chocolate
  • Dairy foods, especially certain cheeses
  • Foods with monosodium glutamate (MSG)
  • Foods with tyramine, which includes red wine, aged cheese, smoked fish, chicken livers, figs, and certain beans
  • Fruits (avocado, banana, citrus fruit)
  • Meats containing nitrates (bacon, hot dogs, salami, cured meats)
  • Onions
  • Peanuts and other nuts and seeds
  • Processed, fermented, pickled, or marinated foods

True migraine headaches are not a result of a brain tumor or other serious medical problem. Only a health care provider who specializes in headaches can determine if your symptoms are due to a migraine or other condition.

Symptoms

There are two main types of migraines:

  • Migraine with aura (classic migraine)
  • Migraine without aura (common migraine)

An aura is a group of nervous system (neurologic) symptoms. These symptoms are considered a warning sign that a migraine is coming. Most often, the vision is affected and can include any or all of the following:

  • Temporary blind spots or colored spots
  • Blurred vision
  • Eye pain
  • Seeing stars, zigzag lines, or flashing lights
  • Tunnel vision (only able to see objects close to the center of the field of view)

Other nervous system symptoms include yawning, difficulty concentrating, nausea, trouble finding the right words, dizziness, weakness, numbness, and tingling. Some of these symptoms are much less common with migraine headaches. If you have any of these symptoms, your provider will likely order tests to find the cause.

An aura often occurs 10 to 15 minutes before the headache, but can occur just a few minutes to 24 hours before. A headache does not always follow an aura.

The headaches usually:

  • Start as a dull ache and get worse within minutes to hours
  • Are throbbing, pounding, or pulsating
  • Are worse on one side of the head with pain behind the eye or in the back of the head and neck
  • Last 4 to 72 hours

Other symptoms that may occur with the headache include:

  • Chills
  • Increased urination
  • Fatigue
  • Loss of appetite
  • Nausea and vomiting
  • Sensitivity to light or sound
  • Sweating

Symptoms may linger, even after the migraine goes away. This is called a migraine hangover. Symptoms can include:

  • Feeling mentally dull, like your thinking is not clear or sharp
  • Needing more sleep
  • Neck pain

Exams and Tests

Your provider can diagnose migraine headache by asking about your symptoms and family history of migraines. A complete physical exam will be done to determine if your headaches are due to muscle tension, sinus problems, or a brain disorder.

There is no specific test to prove that your headache is actually a migraine. In most cases, no special tests are needed. Your provider may order a brain CT or MRI scan if you have never had one before. The test may also be ordered if you have unusual symptoms with your migraine, including weakness, memory problems, or loss of alertness.

An EEG may be needed to rule out seizures. A lumbar puncture (spinal tap) might be done.

Treatment

There is no specific cure for migraine headaches. The goal is to treat your migraine symptoms right away, and to prevent symptoms by avoiding or changing your triggers.

A key step is learning how to manage your migraines at home. A headache diary can help you identify your headache triggers. Then you and your provider can plan how to avoid these triggers.

Lifestyle changes include:

  • Better sleep habits, such as getting enough sleep and going to bed at the same time each night
  • Better eating habits, including not skipping meals and avoiding your food triggers
  • Managing stress 
  • Losing weight, if you're overweight

If you have frequent migraines, your provider may prescribe medicine to reduce the number of attacks. You need to take the medicine every day for it to be effective. Medicines may include:

  • Antidepressants
  • Blood pressure medicines, such as beta blockers
  • Anti-seizure medicines
  • Calcitonin gene-related peptide agents

Botulinum toxin type A (Botox) injections may also help reduce migraine attacks if they occur more than 15 days a month.

Some people find relief with minerals and vitamins. Check with your provider to see if riboflavin or magnesium is right for you.

TREATING AN ATTACK

Other medicines are taken at the first sign of a migraine attack. Over-the-counter (OTC) pain medicines, such as acetaminophen, ibuprofen, or aspirin are often helpful when your migraine is mild. Be aware that:

  • Taking medicines more than 3 days a week may lead to rebound headaches. These are headaches that keep coming back due to overuse of pain medicine.
  • Taking too much acetaminophen can damage your liver.
  • Too much ibuprofen or aspirin can irritate your stomach or kidneys.

If these treatments do not help, ask your provider about prescription medicines. These include nasal sprays, suppositories, or injections. The group of medicines most often used is called triptans.

Some migraine medicines narrow the blood vessels. If you are at risk for having a heart attack or have heart disease, talk with your provider before using these medicines. Some migraine medicines should not be used by pregnant women. Talk with your provider about which medicine is right for you if you are pregnant or planning to become pregnant.

Other medicines treat symptoms of migraine, such as nausea and vomiting. They may be used alone or along with the other drugs that treat the migraine itself.

Feverfew is an herb for migraines. It can be effective for some people. Before using feverfew, make sure your provider approves. Herbal remedies sold in drugstores and health food stores are not regulated. Work with a trained herbalist when selecting herbs.

PREVENTING MIGRAINE HEADACHES

If your migraines occur more than twice a week despite the use of triptans, your provider may place you on medicines to take everyday, which may help prevent your migraines. The goal is prevent how often migraines occur and how severe the headache is. These types of medicines may help prevent or reduce migraine headaches:

  • Medicines commonly used for high blood pressure,(such as beta-blockers, angiotensin blockade agents, and calcium channel blockers)
  • Certain medicines used to treat depression
  • Certain medicines used to treat seizures, called anticonvulsants
  • Botulinum toxin type A injections for select patients

Newer devices that provide different kinds of nerve stimulation or magnetic stimulation are also being evaluated for treatment of migraine headaches. Their exact role in treating migraines remains unclear.

Outlook (Prognosis)

Each person responds differently to treatment. Some people have migraines only rarely and need little to no treatment. Others need to take several medicines or even go to the hospital sometimes.

Migraine headache is a risk factor for stroke. Risk is higher in people who smoke, more so in women who have migraines that occur with aura. In addition to not smoking, people with migraines should avoid other risk factors for stroke. These include: 

  • Taking birth control pills
  • Eating unhealthy foods, which can cause high cholesterol or high blood pressure

When to Contact a Medical Professional

Call 911 if:

  • You are experiencing "the worst headache of your life."
  • You have speech, vision, or movement problems or loss of balance, especially if you have not had these symptoms with a migraine before.
  • A headache starts suddenly.

Schedule an appointment or call your provider if:

  • Your headache pattern or pain changes.
  • Treatments that once worked no longer help.
  • You have side effects from your medicine.
  • You are taking birth control pills and have migraine headaches.
  • Your headaches are more severe when lying down.

References

American Headache Society. The American headache society position statement on integrating new migraine treatments into clinical practice. Headache. 2019;59(1):1-18. PMID: 30536394 www.ncbi.nlm.nih.gov/pubmed/30536394.

Dodick DW. Migraine. Lancet. 2018;391(10127):1315-1330. PMID: 29523342 www.ncbi.nlm.nih.gov/pubmed/29523342.

Garza I, Schwedt TJ, Robertson CE, Smith JH. Headache and other craniofacial pain. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice. 7th ed. Philadelphia, PA: Elsevier; 2016:chap 103.

Herd CP, Tomlinson CL, Rick C, et al. Botulinum toxins for the prevention of migraine in adults. Cochrane Database Syst Rev. 2018;6:CD011616. PMID: 29939406 pubmed.ncbi.nlm.nih.gov/29939406/.

Hershey AD, Kabbouche MA, O'Brien HL, Kacperski J. Headaches. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 613.

Practice guideline update summary: Acute treatment of migraine in children and adolescents: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2020;94(1):50. PMID: 31822576 pubmed.ncbi.nlm.nih.gov/31822576/.

Tassorelli C, Diener HC, Dodick DW, et al. Guidelines of the International Headache Society for controlled trials of preventive treatment of chronic migraine in adults. Cephalalgia. 2018;38(5):815–832. PMID: 29504482 pubmed.ncbi.nlm.nih.gov/29504482/.

  • Migraine

    Animation

  •  

    Migraine - Animation

    Migraines aren't your average, run-of-the-mill headaches. When you have a migraine, it feels like your head is throbbing, every light is glaring, and all you want to do is lie down in a dark room. Let's talk about migraines. We know that migraines are more common in women than in men. But what exactly triggers these severe headaches is less clear, and it's different in different people. For some people the trigger is stress. For others, it's strong odors like perfumes. Changing hormones around the time of a woman's menstrual period can set off a migraine. So can certain foods like chocolate, cured meats, red wine, and aged cheese. Doctors believe that whatever triggers a migraine sets off a chain of abnormal activities in brain chemicals and nerves. These activities affect the flow of blood through the brain. A migraine feels different than a regular headache. For one thing, it often comes with a warning. Some people get a sign that their migraine is coming, called an aura. About 10 to 15 minutes before the actual headache hits, their vision gets blurry or narrowed, and they may see stars or zigzag lines. A migraine feels like a throbbing or pounding pain that tends to be worse on one side of the head. You may also have symptoms like nausea, vomiting, numbness, chills, and sensitivity to light or sound. A migraine can typically last anywhere from 6 hours to 2 days. When it's over, people get what's described as a "hangover," in which they feel tired and can't think clearly. If you're plagued by migraines, your doctor will help you figure out the cause. You may need to have a brain scan such as an MRI or CT, especially if you have other symptoms like memory problems or weakness with your migraines. So, what can be done to treat migraines? Doctors use a few different types of medicines to prevent and treat migraines. You can take antidepressants, blood pressure medicines, or seizure medicines every day to prevent migraines from starting. Some people have great success preventing migraines using biofeedback devices or hypnosis. Once you do get a migraine, you can take medicines right away to stop it. Triptans such as Imitrex and Maxalt are the most commonly prescribed medicines for stopping a migraine. Depending on your migraine symptoms and how bad they are, your doctor may also recommend a pain reliever such as ibuprofen, or a nausea medicine. To prevent migraines, you also need to avoid your triggers, but first you need to identify what they are. Your doctor may recommend keeping a headache diary, in which you write down when your headaches occur and what you were eating or doing when you got a migraine. Take care of yourself when you have a migraine. If you only get them occasionally, there's probably no cause for worry. But if you get migraines often, and they're interfering with your life or they're getting worse, talk to your doctor about ways to prevent and treat them.

  • Migraine headache

    Migraine headache - illustration

    Symptoms of a migraine attack may include heightened sensitivity to light and sound, nausea, auras (loss of vision in one eye or tunnel vision), difficulty of speech and intense pain predominating on one side of the head.

    Migraine headache

    illustration

  • Migraine cause

    Migraine cause - illustration

    One theory of the cause of migraine is a central nervous system (CNS) disorder. The CNS consists of the brain and spinal cord. In migraine, various stimuli may cause a series of neurologic and biochemical events which affect the brain's vascular system.

    Migraine cause

    illustration

  • CT scan of the brain

    CT scan of the brain - illustration

    A CT or CAT scan (computed tomography) is a much more sensitive imaging technique than X-ray, allowing high definition not only of the bony structures, but of the soft tissues. Clear images of organs such as the brain, muscles, joint structures, veins and arteries, as well as anomalies like tumors and hemorrhages may be obtained with or without the injection of contrasting dye.

    CT scan of the brain

    illustration

  • Central nervous system and peripheral nervous system

    Central nervous system and peripheral nervous system - illustration

    The central nervous system comprises the brain and spinal cord. The peripheral nervous system includes all peripheral nerves.

    Central nervous system and peripheral nervous system

    illustration

  • Migraine

    Animation

  •  

    Migraine - Animation

    Migraines aren't your average, run-of-the-mill headaches. When you have a migraine, it feels like your head is throbbing, every light is glaring, and all you want to do is lie down in a dark room. Let's talk about migraines. We know that migraines are more common in women than in men. But what exactly triggers these severe headaches is less clear, and it's different in different people. For some people the trigger is stress. For others, it's strong odors like perfumes. Changing hormones around the time of a woman's menstrual period can set off a migraine. So can certain foods like chocolate, cured meats, red wine, and aged cheese. Doctors believe that whatever triggers a migraine sets off a chain of abnormal activities in brain chemicals and nerves. These activities affect the flow of blood through the brain. A migraine feels different than a regular headache. For one thing, it often comes with a warning. Some people get a sign that their migraine is coming, called an aura. About 10 to 15 minutes before the actual headache hits, their vision gets blurry or narrowed, and they may see stars or zigzag lines. A migraine feels like a throbbing or pounding pain that tends to be worse on one side of the head. You may also have symptoms like nausea, vomiting, numbness, chills, and sensitivity to light or sound. A migraine can typically last anywhere from 6 hours to 2 days. When it's over, people get what's described as a "hangover," in which they feel tired and can't think clearly. If you're plagued by migraines, your doctor will help you figure out the cause. You may need to have a brain scan such as an MRI or CT, especially if you have other symptoms like memory problems or weakness with your migraines. So, what can be done to treat migraines? Doctors use a few different types of medicines to prevent and treat migraines. You can take antidepressants, blood pressure medicines, or seizure medicines every day to prevent migraines from starting. Some people have great success preventing migraines using biofeedback devices or hypnosis. Once you do get a migraine, you can take medicines right away to stop it. Triptans such as Imitrex and Maxalt are the most commonly prescribed medicines for stopping a migraine. Depending on your migraine symptoms and how bad they are, your doctor may also recommend a pain reliever such as ibuprofen, or a nausea medicine. To prevent migraines, you also need to avoid your triggers, but first you need to identify what they are. Your doctor may recommend keeping a headache diary, in which you write down when your headaches occur and what you were eating or doing when you got a migraine. Take care of yourself when you have a migraine. If you only get them occasionally, there's probably no cause for worry. But if you get migraines often, and they're interfering with your life or they're getting worse, talk to your doctor about ways to prevent and treat them.

  • Migraine headache

    Migraine headache - illustration

    Symptoms of a migraine attack may include heightened sensitivity to light and sound, nausea, auras (loss of vision in one eye or tunnel vision), difficulty of speech and intense pain predominating on one side of the head.

    Migraine headache

    illustration

  • Migraine cause

    Migraine cause - illustration

    One theory of the cause of migraine is a central nervous system (CNS) disorder. The CNS consists of the brain and spinal cord. In migraine, various stimuli may cause a series of neurologic and biochemical events which affect the brain's vascular system.

    Migraine cause

    illustration

  • CT scan of the brain

    CT scan of the brain - illustration

    A CT or CAT scan (computed tomography) is a much more sensitive imaging technique than X-ray, allowing high definition not only of the bony structures, but of the soft tissues. Clear images of organs such as the brain, muscles, joint structures, veins and arteries, as well as anomalies like tumors and hemorrhages may be obtained with or without the injection of contrasting dye.

    CT scan of the brain

    illustration

  • Central nervous system and peripheral nervous system

    Central nervous system and peripheral nervous system - illustration

    The central nervous system comprises the brain and spinal cord. The peripheral nervous system includes all peripheral nerves.

    Central nervous system and peripheral nervous system

    illustration

A Closer Look

 

Self Care

 
 

Review Date: 2/4/2020

Reviewed By: Amit M. Shelat, DO, FACP, FAAN, Attending Neurologist and Assistant Professor of Clinical Neurology, Stony Brook University School of Medicine, Stony Brook, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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