BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuFactor V deficiencyParahemophilia; Owren disease; Bleeding disorder - factor V deficiencyFactor V deficiency is a bleeding disorder that is passed down through families. It affects the ability of the blood to clot.Bleeding disorderBleeding disorders are a group of conditions in which there is a problem with the body's blood clotting process. These disorders can lead to heavy a...Read Article Now Book Mark Article Causes Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors. Factor V deficiency is caused by a lack of factor V. When certain blood clotting factors are low or missing, your blood does not clot properly. Factor V deficiency is rare. It may be caused by: A defective factor V gene passed down through families (inherited) An antibody that interferes with normal factor V function You can develop an antibody that interferes with factor V:After giving birth After being treated with a certain type of fibrin glue After surgery With autoimmune diseases and certain cancers Sometimes the cause is unknown.The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of factor V deficiency, a family history of a bleeding disorder is a risk factor.HemophiliaHemophilia refers to a group of bleeding disorders in which blood clotting takes a longer time than normal. There are two forms of hemophilia:Hemophi...ImageRead Article Now Book Mark Article Symptoms Excessive bleeding with menstrual periods and after childbirth often occurs. Other symptoms can include: Bleeding into the skin Bleeding into the skinBleeding into the skin can occur from broken blood vessels that form tiny red dots (called petechiae). Blood also can collect under the tissue in la...ImageRead Article Now Book Mark Article Bleeding of the gums Bleeding of the gumsBleeding gums can be a sign that you have or may develop gum disease. Ongoing gum bleeding may be due to plaque buildup on the teeth. It can also b...Read Article Now Book Mark Article Excessive bruising BruisingBleeding into the skin can occur from broken blood vessels that form tiny red dots (called petechiae). Blood also can collect under the tissue in la...ImageRead Article Now Book Mark Article Nosebleeds Prolonged or excessive loss of blood with surgery or trauma Umbilical stump bleeding Exams and Tests Tests to detect factor V deficiency include:Factor V assay Factor V assayThe factor V assay is a blood test to measure the activity of factor V. This is one of the proteins in the body that helps the blood clot.Read Article Now Book Mark Article Blood clotting tests, including partial thromboplastin time (PTT) and prothrombin time Partial thromboplastin timePartial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. It can help tell if you have a bleeding problem...Read Article Now Book Mark Article Prothrombin timeProthrombin time (PT) is a blood test that measures the time it takes for the liquid portion (plasma) of your blood to clot. It measures the functio...Read Article Now Book Mark Article Bleeding timeBleeding timeBleeding time is a medical test that measures how fast small blood vessels in the skin stop bleeding. Because it is difficult to perform correctly, i...ImageRead Article Now Book Mark Article Treatment You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily. Outlook (Prognosis) The outlook is good with diagnosis and proper treatment. Possible Complications Severe bleeding (hemorrhage) could occur. When to Contact a Medical Professional Go to the emergency room or call 911 or the local emergency number if you have an unexplained or prolonged loss of blood.Open ReferencesReferencesGailani D, Wheeler AP, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 137.Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 165.Scott JP, Flood VH. Hereditary clotting factor deficiencies (bleeding disorders). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 503.AllVideoImagesTogBlood clot formation - illustration Blood clotting normally occurs when there is damage to a blood vessel. Platelets immediately begin to adhere to the cut edges of the vessel and release chemicals to attract even more platelets. A platelet plug is formed, and the external bleeding stops. Next, small molecules, called clotting factors, cause strands of blood-borne materials, called fibrin, to stick together and seal the inside of the wound. Eventually, the cut blood vessel heals and the blood clot dissolves after a few days.Blood clot formationillustrationBlood clots - illustration Blood clots (fibrin clots) are the clumps that result when blood coagulates.Blood clotsillustrationBlood clot formation - illustration Blood clotting normally occurs when there is damage to a blood vessel. Platelets immediately begin to adhere to the cut edges of the vessel and release chemicals to attract even more platelets. A platelet plug is formed, and the external bleeding stops. Next, small molecules, called clotting factors, cause strands of blood-borne materials, called fibrin, to stick together and seal the inside of the wound. Eventually, the cut blood vessel heals and the blood clot dissolves after a few days.Blood clot formationillustrationBlood clots - illustration Blood clots (fibrin clots) are the clumps that result when blood coagulates.Blood clotsillustrationRelated Information Protein in diet(Nutrition)Hemophilia(Condition)Bleeding disorders(Condition) Review Date: 1/25/2022 Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. 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Factor V deficiencyParahemophilia; Owren disease; Bleeding disorder - factor V deficiencyFactor V deficiency is a bleeding disorder that is passed down through families. It affects the ability of the blood to clot.Bleeding disorderBleeding disorders are a group of conditions in which there is a problem with the body's blood clotting process. These disorders can lead to heavy a...Read Article Now Book Mark Article Causes Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors. Factor V deficiency is caused by a lack of factor V. When certain blood clotting factors are low or missing, your blood does not clot properly. Factor V deficiency is rare. It may be caused by: A defective factor V gene passed down through families (inherited) An antibody that interferes with normal factor V function You can develop an antibody that interferes with factor V:After giving birth After being treated with a certain type of fibrin glue After surgery With autoimmune diseases and certain cancers Sometimes the cause is unknown.The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of factor V deficiency, a family history of a bleeding disorder is a risk factor.HemophiliaHemophilia refers to a group of bleeding disorders in which blood clotting takes a longer time than normal. There are two forms of hemophilia:Hemophi...ImageRead Article Now Book Mark Article Symptoms Excessive bleeding with menstrual periods and after childbirth often occurs. Other symptoms can include: Bleeding into the skin Bleeding into the skinBleeding into the skin can occur from broken blood vessels that form tiny red dots (called petechiae). Blood also can collect under the tissue in la...ImageRead Article Now Book Mark Article Bleeding of the gums Bleeding of the gumsBleeding gums can be a sign that you have or may develop gum disease. Ongoing gum bleeding may be due to plaque buildup on the teeth. It can also b...Read Article Now Book Mark Article Excessive bruising BruisingBleeding into the skin can occur from broken blood vessels that form tiny red dots (called petechiae). Blood also can collect under the tissue in la...ImageRead Article Now Book Mark Article Nosebleeds Prolonged or excessive loss of blood with surgery or trauma Umbilical stump bleeding Exams and Tests Tests to detect factor V deficiency include:Factor V assay Factor V assayThe factor V assay is a blood test to measure the activity of factor V. This is one of the proteins in the body that helps the blood clot.Read Article Now Book Mark Article Blood clotting tests, including partial thromboplastin time (PTT) and prothrombin time Partial thromboplastin timePartial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. It can help tell if you have a bleeding problem...Read Article Now Book Mark Article Prothrombin timeProthrombin time (PT) is a blood test that measures the time it takes for the liquid portion (plasma) of your blood to clot. It measures the functio...Read Article Now Book Mark Article Bleeding timeBleeding timeBleeding time is a medical test that measures how fast small blood vessels in the skin stop bleeding. Because it is difficult to perform correctly, i...ImageRead Article Now Book Mark Article Treatment You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily. Outlook (Prognosis) The outlook is good with diagnosis and proper treatment. Possible Complications Severe bleeding (hemorrhage) could occur. When to Contact a Medical Professional Go to the emergency room or call 911 or the local emergency number if you have an unexplained or prolonged loss of blood.Open ReferencesReferencesGailani D, Wheeler AP, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 137.Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 165.Scott JP, Flood VH. Hereditary clotting factor deficiencies (bleeding disorders). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 503.