Diabetes and kidney disease
Diabetic nephropathy; Nephropathy - diabetic; Diabetic glomerulosclerosis; Kimmelstiel-Wilson diseaseKidney disease or kidney damage often occurs over time in people with diabetes. This type of kidney disease is called diabetic nephropathy.
Causes
Each kidney is made of hundreds of thousands of small units called nephrons. These structures filter your blood, help remove waste from the body, and control fluid balance.
In people with diabetes, the nephrons slowly thicken and become scarred over time. The nephrons begin to leak, and protein (albumin) passes into the urine. This damage can happen years before any symptoms of kidney disease begin. Some people who have type 2 diabetes that develops slowly already have kidney damage when they are first diagnosed.
Diabetes
Diabetes is a long-term (chronic) disease in which the body cannot regulate the amount of sugar in the blood.
Read Article Now Book Mark ArticleKidney damage is more likely if you:
- Have uncontrolled blood sugar (glucose)
- Are obese
- Have high blood pressure
- Have type 1 diabetes that began before you were 20 years old
- Have family members who also have diabetes and kidney problems
- Smoke
- Are African American, Mexican American, or Native American
Symptoms
Often, there are no symptoms as the kidney damage starts and slowly gets worse. Kidney damage can begin 5 to 10 years before symptoms start.
People who have more severe and long-term (chronic) kidney disease may have symptoms such as:
- Fatigue most of the time
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General ill feeling
General ill feeling
Malaise is a general feeling of discomfort, illness, or lack of well-being.
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- Irregular heartbeat
- Nausea and vomiting
- Poor appetite
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Swelling of the legs
Swelling of the legs
Painless swelling of the feet and ankles is a common problem, especially among older people. Abnormal buildup of fluid in the ankles, feet, and legs ...
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- Itchy skin
- Easily develop infections
Exams and Tests
Your health care provider will order tests to detect signs of kidney problems.
A urine test looks for a protein, called albumin, leaking into the urine.
- Too much albumin in the urine is often a sign of kidney damage.
- This test is also called a microalbuminuria test because it measures small amounts of albumin.
Microalbuminuria
This test looks for a protein called albumin in a urine sample. Albumin can also be measured using a blood test or another urine test, called the pro...
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Your provider will also check your blood pressure. High blood pressure damages your kidneys, and blood pressure is harder to control when you have kidney damage.
A kidney biopsy may be ordered to confirm the diagnosis or look for other causes of kidney damage.
Kidney biopsy
A kidney biopsy is the removal of a small piece of kidney tissue for examination.
Read Article Now Book Mark ArticleIf you have diabetes, your provider will also check your kidneys by using the following blood tests every year:
- Blood urea nitrogen (BUN)
BUN
BUN stands for blood urea nitrogen. Urea nitrogen is what forms when protein breaks down. A test can be done to measure the amount of urea nitrogen ...
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Serum creatinine
Serum creatinine
The creatinine blood test measures the level of creatinine in the blood. This test is done to see how well your kidneys are working. Creatinine in t...
Read Article Now Book Mark Article - Estimated glomerular filtration rate (eGFR)
Treatment
When kidney damage is caught in its early stages, it can be slowed with treatment. Once larger amounts of protein appear in the urine, kidney damage will slowly get worse.
Follow your provider's advice to keep your condition from getting worse.
CONTROL YOUR BLOOD PRESSURE
Hypertension is another term used to describe high blood pressure. High blood pressure can lead to: StrokeHeart attackHeart failureKidney diseaseEar...
Read Article Now Book Mark ArticleKeeping your blood pressure under control (below 130/80 mm Hg) is one of the best ways to slow kidney damage.
- Your provider will prescribe blood pressure medicines known as ACE inhibitors or angiotensin II receptor blockers to protect your kidneys from more damage if your microalbumin test is too high on at least two measurements.
- If your blood pressure is in the normal range and you have microalbuminuria, you may still benefit from these medicines. Your provider can help you decide what is best for you.
CONTROL YOUR BLOOD SUGAR LEVEL
You can also slow kidney damage by controlling your blood sugar level through:
- Eating healthy foods
-
Getting regular exercise
Getting regular exercise
Exercise is an important part of managing your diabetes. If you are obese or overweight, exercise can help you manage your weight.
Read Article Now Book Mark Article - Taking oral or injectable medicines as instructed by your provider
- Some diabetes medicines are known to prevent the progression of diabetic nephropathy better than other medicines. Talk to your provider about which medicines are best for you.
- Checking your blood sugar level as often as instructed and keeping a record of your blood sugar numbers so that you know how meals and activities affect your level
OTHER WAYS TO PROTECT YOUR KIDNEYS
- Contrast dye that is sometimes used with an MRI, CT scan, or other imaging test can cause more damage to your kidneys. Tell the provider who is ordering the test that you have diabetes. Follow instructions about drinking lots of water after the procedure to flush the dye out of your system.
- Avoid taking an NSAID pain medicine, such as ibuprofen or naproxen. Ask your provider if there is another kind of medicine that you can take instead. NSAIDs can damage the kidneys, more so when you use them every day.
- Your provider may need to stop or change other medicines that can damage your kidneys.
- Know the signs of urinary tract infections and get them treated right away.
- Having a low level of vitamin D may worsen kidney disease. Ask your doctor if you need to take vitamin D supplements.
- Do not use tobacco.
Support Groups
Many resources can help you understand more about diabetes. You can also learn ways to manage your kidney disease.
Resources
The following sites provide further information on diabetes:American Diabetes Association -- www. diabetes. orgCenters for Disease Control and Preven...
Read Article Now Book Mark ArticleOutlook (Prognosis)
Diabetic kidney disease is a major cause of sickness and death in people with diabetes. It can lead to the need for dialysis or a kidney transplant.
Dialysis
Dialysis treats end-stage kidney failure. It removes harmful substances from the blood when the kidneys cannot. This article focuses on peritoneal d...
Read Article Now Book Mark ArticleKidney transplant
A kidney transplant is surgery to place a healthy kidney into a person with kidney failure.
Read Article Now Book Mark ArticleWhen to Contact a Medical Professional
Contact your provider if you have diabetes and you have not had a urine test to check for protein.
References
Brownlee M, Aiello LP, Sun JK, et al. Complications of diabetes mellitus. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 37.
ElSayed NA, Aleppo G, Aroda VR, et al. 12. Retinopathy, neuropathy, and foot care: standards of care in diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S203-S215. PMID: 36507636 pubmed.ncbi.nlm.nih.gov/36507636/.
Tong LL, Adler S, Wanner C. Prevention and treatment of diabetic kidney disease. In: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Comprehensive Clinical Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 31.
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Diabetes
Animation
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Male urinary system - illustration
The urinary system is made up of the kidneys, ureters, urethra and bladder.
Male urinary system
illustration
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Pancreas and kidneys - illustration
Uncontrolled diabetes causes damage to many tissues of the body including the kidneys. Kidney damage caused by diabetes most often involves thickening and hardening of the internal kidney structures. Strict blood glucose control may delay the progression of kidney disease in type 1 and type 2 diabetics.
Pancreas and kidneys
illustration
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Diabetic nephropathy - illustration
During diabetic nephropathy the kidney becomes damaged and more protein than normal collects in the urine. As the disease progresses, more of the kidney is destroyed. Over time, the kidneys ability to function starts to decline, which may eventually lead to chronic kidney failure.
Diabetic nephropathy
illustration
-
Male urinary system - illustration
The urinary system is made up of the kidneys, ureters, urethra and bladder.
Male urinary system
illustration
-
Pancreas and kidneys - illustration
Uncontrolled diabetes causes damage to many tissues of the body including the kidneys. Kidney damage caused by diabetes most often involves thickening and hardening of the internal kidney structures. Strict blood glucose control may delay the progression of kidney disease in type 1 and type 2 diabetics.
Pancreas and kidneys
illustration
-
Diabetic nephropathy - illustration
During diabetic nephropathy the kidney becomes damaged and more protein than normal collects in the urine. As the disease progresses, more of the kidney is destroyed. Over time, the kidneys ability to function starts to decline, which may eventually lead to chronic kidney failure.
Diabetic nephropathy
illustration
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Review Date: 2/10/2023
Reviewed By: Sandeep K. Dhaliwal, MD, board-certified in Diabetes, Endocrinology, and Metabolism, Springfield, VA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.