Hyperthyroidism
Thyrotoxicosis; Overactive thyroid; Graves disease - hyperthyroidism; Thyroiditis - hyperthyroidism; Toxic goiter - hyperthyroidism; Thyroid nodules - hyperthyroidism; Thyroid hormone - hyperthyroidismHyperthyroidism is a condition in which the thyroid gland makes too much thyroid hormone. The condition is often called overactive thyroid.
Causes
The thyroid gland is an important organ of the endocrine system. It is located at the front of the neck just above where your collarbones meet. The gland makes the hormones that control the way every cell in the body uses energy. This process is called metabolism.
Endocrine
Endocrine glands release (secrete) hormones into the bloodstream. The endocrine glands include:AdrenalHypothalamusIslets of Langerhans in the pancrea...
Read Article Now Book Mark ArticleMetabolism
Metabolism refers to all the physical and chemical processes in the body that convert or use energy, such as:BreathingCirculating bloodControlling bo...
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Thyroid gland
The thyroid gland, a part of the endocrine (hormone) system, plays a major role in regulating the body's metabolism.
Many diseases and conditions can cause hyperthyroidism, including:
-
Graves disease (most common cause of hyperthyroidism)
Graves disease
Graves disease is an autoimmune disorder that leads to an overactive thyroid gland (hyperthyroidism). An autoimmune disorder is a condition that occ...
Read Article Now Book Mark Article - Inflammation (thyroiditis) of the thyroid due to viral infections, some medicines, or after pregnancy (common)
- Taking too much thyroid hormone (common)
- Noncancerous growths of the thyroid gland or pituitary gland (rare)
- Some tumors of the testes or ovaries (rare)
Testes
The testes are 2 egg-shaped male reproductive organs located in the scrotum. They produce sperm and the male hormone, testosterone.
Read Article Now Book Mark Article - Getting medical imaging tests with contrast dye that has iodine (rare, and only if there is already a problem with the thyroid)
- Eating too much of foods that contain iodine (very rare, and only if there is already a problem with the thyroid)
Brain-thyroid link
Although the thyroid gland releases the hormones which govern growth and metabolism, the brain (the pituitary and the hypothalamus) manages the release and the balance of the amount of hormones circulated.
Symptoms
Common symptoms include:
- Anxiety
- Difficulty concentrating
-
Fatigue
Fatigue
Fatigue is a feeling of weariness, tiredness, or lack of energy.
Read Article Now Book Mark Article - Frequent bowel movements
-
Goiter (visibly enlarged thyroid gland) or thyroid nodules
Goiter
A simple goiter is an enlargement of the thyroid gland. It is usually not a tumor or cancer.
Read Article Now Book Mark ArticleThyroid nodules
A thyroid nodule is a growth (lump) in the thyroid gland. The thyroid gland is located at the front of the neck, just above where your collarbones m...
Read Article Now Book Mark Article - Hair loss
-
Hand tremor
Hand tremor
A tremor is a type of shaking movement. A tremor is most often noticed in the hands and arms. It may affect any body part, including the head, tong...
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Heat intolerance
Heat intolerance
Heat intolerance is a feeling of being overheated when the temperature around you rises. It can often cause heavy sweating. Heat intolerance usually...
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Increased appetite
Increased appetite
Increased appetite means you have an excess desire for food.
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Increased sweating
Increased sweating
Sweating is the release of liquid from the body's sweat glands. This liquid contains salt. This process is also called perspiration. Sweating helps...
Read Article Now Book Mark Article - Irregular menstrual periods in women
- Nail changes (thickness or flaking)
- Nervousness
- Pounding or racing heart beat (palpitations)
Palpitations
Palpitations are feelings or sensations that your heart is pounding or racing. They can be felt in your chest, throat, or neck. You may:Have an unpl...
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Restlessness
Restlessness
Agitation is an unpleasant state of extreme arousal. An agitated person may feel stirred up, excited, tense, confused, or irritable.
Read Article Now Book Mark Article - Sleep problems
-
Weight loss (or weight gain, in some cases)
Weight loss
Unexplained weight loss is a decrease in body weight, when you did not try to lose the weight on your own. Many people gain and lose weight. Uninten...
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Goiter
A goiter is a swelling in the neck due to an enlarged thyroid gland. The size may range from a single small nodule to a large neck lump. The swollen thyroid can put pressure on the windpipe and esophagus which can cause a cough, wheezing, breathing difficulties or swallowing difficulties. A goiter only needs to be treated if it is causing symptoms.
Other symptoms that can occur with this condition:
- Breast development in men
- Clammy skin
- Diarrhea
- Feeling faint when you raise your hands
-
High blood pressure
High blood pressure
Blood pressure is a measurement of the force exerted against the walls of your arteries as your heart pumps blood to your body. Hypertension is the ...
Read Article Now Book Mark Article - Itchy or irritated eyes
- Itchy skin
- Nausea and vomiting
-
Protruding eyes (exophthalmos)
Protruding eyes
Bulging eyes is the abnormal protrusion (bulging out) of one or both eyeballs.
Read Article Now Book Mark Article - Skin blushing or flushing
- Skin rash on the shins
- Weakness of the hips and shoulders
Endocrine glands
Endocrine glands release hormones (chemical messengers) into the bloodstream to be transported to various organs and tissues throughout the body. For instance, the pancreas secretes insulin, which allows the body to regulate levels of sugar in the blood. The thyroid gets instructions from the pituitary to secrete hormones which determine the rate of metabolism in the body (the more hormone in the bloodstream, the faster the chemical activity; the less hormone, the slower the activity).
Exams and Tests
The health care provider will do a physical exam. The exam may find the following:
- High systolic blood pressure (the first number in a blood pressure reading)
- Increased heart rate
- Enlarged thyroid gland
- Shaking of the hands
- Swelling or inflammation around the eyes
- Very strong reflexes
Reflexes
A reflex is a muscle reaction that happens automatically in response to stimulation. Certain sensations or movements produce specific muscle respons...
Read Article Now Book Mark Article - Skin, hair, and nail changes
Blood tests are also ordered to measure your thyroid hormones TSH, T3, and T4.
TSH
A TSH test measures the amount of thyroid stimulating hormone (TSH) in your blood. TSH is produced by the pituitary gland. It prompts the thyroid g...
Read Article Now Book Mark ArticleYou may also have blood tests to check:
- Cholesterol levels
-
Glucose
Glucose
A blood sugar test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the...
Read Article Now Book Mark Article - Specialized thyroid tests like Thyroid receptor antibody (TRAb) or Thyroid Stimulating Immunoglobulin (TSI)
Thyroid Stimulating Immunoglobulin (TSI
TSI stands for thyroid stimulating immunoglobulin. TSIs are antibodies that tell the thyroid gland to become more active and release excess amounts ...
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Imaging tests of the thyroid may also be needed, including:
-
Radioactive iodine uptake and scan
Radioactive iodine uptake and scan
Radioactive iodine uptake (RAIU) tests thyroid function. It measures how much radioactive iodine is taken up by your thyroid gland in a certain time...
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Thyroid ultrasound (rarely)
Thyroid ultrasound
A thyroid ultrasound is an imaging method to see the thyroid, a gland in the neck that regulates metabolism (the many processes that control the rate...
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Treatment
Treatment depends on the cause and severity of symptoms. Hyperthyroidism is usually treated with one or more of the following:
- Antithyroid medicines (propylthiouracil or methimazole) which reduce or block the effects of the extra thyroid hormone
- Radioactive iodine to destroy the thyroid gland and stop the excess production of hormones
- Surgery to remove the thyroid
If your thyroid is removed with surgery or destroyed with radioactive iodine, you must take thyroid hormone replacement pills for the rest of your life.
Medicines called beta-blockers may be prescribed to treat symptoms such as fast heart rate, tremor, sweating, and anxiety until the hyperthyroidism can be controlled.
Outlook (Prognosis)
Hyperthyroidism is treatable. Some causes may go away without treatment.
Hyperthyroidism caused by Graves disease usually gets worse over time. It has many complications, some of which are severe and affect quality of life.
Possible Complications
Thyroid crisis (also called thyroid storm) is a sudden worsening of hyperthyroidism symptoms that may occur with infection or stress. Fever, decreased alertness, and abdominal pain may occur. People need to be treated in the hospital.
Other complications of hyperthyroidism include:
- Heart problems such as fast heart rate, abnormal heart rhythm, and heart failure
- Osteoporosis
- Eye disease (double vision, ulcers of the cornea, vision loss)
Surgery-related complications, including:
- Scarring of the neck
- Hoarseness due to nerve damage to the voice box
- Low calcium level due to damage to the parathyroid glands (located near the thyroid gland)
- Hypothyroidism (underactive thyroid)
Tobacco use may make some complications of hyperthyroidism worse.
When to Contact a Medical Professional
Contact your provider if you have symptoms of hyperthyroidism. Go to an emergency room or call 911 or the local emergency number if you have:
- Change in consciousness
- Dizziness
- Rapid, irregular heartbeat
Contact your provider if you are being treated for hyperthyroidism and you develop symptoms of underactive thyroid, including:
- Depression
- Mental and physical sluggishness
- Weight gain
References
Hollenberg A, Wiersinga WM. Hyperthyroid disorders. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 12.
Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016;26(10):1343-1421. PMID: 27521067 pubmed.ncbi.nlm.nih.gov/27521067/.
Wang TS, Sosa JA. Management of hyperthyroidism. In: Cameron AM, Cameron JL, eds. Current Surgical Therapy. 13th ed. Philadelphia, PA: Elsevier; 2020:767-774.
Weiss RE, Refetoff S. Thyroid function testing. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 78.
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Endocrine glands - illustration
Endocrine glands release hormones (chemical messengers) into the bloodstream to be transported to various organs and tissues throughout the body. For instance, the pancreas secretes insulin, which allows the body to regulate levels of sugar in the blood. The thyroid gets instructions from the pituitary to secrete hormones which determine the rate of metabolism in the body (the more hormone in the bloodstream, the faster the chemical activity; the less hormone, the slower the activity).
Endocrine glands
illustration
-
Goiter - illustration
A goiter is a swelling in the neck due to an enlarged thyroid gland. The size may range from a single small nodule to a large neck lump. The swollen thyroid can put pressure on the windpipe and esophagus which can cause a cough, wheezing, breathing difficulties or swallowing difficulties. A goiter only needs to be treated if it is causing symptoms.
Goiter
illustration
-
Brain-thyroid link - illustration
Although the thyroid gland releases the hormones which govern growth and metabolism, the brain (the pituitary and the hypothalamus) manages the release and the balance of the amount of hormones circulated.
Brain-thyroid link
illustration
-
Thyroid gland - illustration
The thyroid gland, a part of the endocrine (hormone) system, plays a major role in regulating the body's metabolism.
Thyroid gland
illustration
-
Endocrine glands - illustration
Endocrine glands release hormones (chemical messengers) into the bloodstream to be transported to various organs and tissues throughout the body. For instance, the pancreas secretes insulin, which allows the body to regulate levels of sugar in the blood. The thyroid gets instructions from the pituitary to secrete hormones which determine the rate of metabolism in the body (the more hormone in the bloodstream, the faster the chemical activity; the less hormone, the slower the activity).
Endocrine glands
illustration
-
Goiter - illustration
A goiter is a swelling in the neck due to an enlarged thyroid gland. The size may range from a single small nodule to a large neck lump. The swollen thyroid can put pressure on the windpipe and esophagus which can cause a cough, wheezing, breathing difficulties or swallowing difficulties. A goiter only needs to be treated if it is causing symptoms.
Goiter
illustration
-
Brain-thyroid link - illustration
Although the thyroid gland releases the hormones which govern growth and metabolism, the brain (the pituitary and the hypothalamus) manages the release and the balance of the amount of hormones circulated.
Brain-thyroid link
illustration
-
Thyroid gland - illustration
The thyroid gland, a part of the endocrine (hormone) system, plays a major role in regulating the body's metabolism.
Thyroid gland
illustration
Review Date: 8/12/2022
Reviewed By: Sandeep K. Dhaliwal, MD, board-certified in Diabetes, Endocrinology, and Metabolism, Springfield, VA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.