BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuCraniopharyngiomaA craniopharyngioma is a noncancerous (benign) tumor that develops at the base of the brain near the pituitary gland.TumorA tumor is an abnormal growth of body tissue. Tumors can be cancerous (malignant) or noncancerous (benign).Read Article Now Book Mark Article Causes The exact cause of the tumor is unknown.This tumor most commonly affects children between 5 to 10 years of age. Adults can sometimes be affected. Boys and girls are equally likely to develop this tumor. Symptoms Craniopharyngioma causes symptoms by:Increasing pressure on the brain, usually from hydrocephalus HydrocephalusHydrocephalus is a buildup of fluid inside the skull that leads to the brain pushing against the skull. Hydrocephalus means "water on the brain. "...ImageRead Article Now Book Mark Article Disrupting hormone production by the pituitary gland Pressure or damage to the optic nerveDamage to the optic nerveOptic nerve atrophy is damage to the optic nerve. The optic nerve carries images of what the eye sees to the brain.ImageRead Article Now Book Mark Article Increased pressure on the brain can cause:Headache Nausea Vomiting (especially in the morning)Damage to the pituitary gland causes hormone imbalances that can lead to excessive thirst and urination, and slow growth.When the optic nerve is damaged by the tumor, vision problems develop. These defects are often permanent. They may get worse after surgery to remove the tumor.Behavioral and learning problems may be present. Exams and Tests Your health care provider will perform a physical exam. Tests will be done to check for a tumor. These may include:Blood tests to measure hormone levels CT scan or MRI scan of the brain CT scanA head computed tomography (CT) scan uses many x-rays to create pictures of the head, including the skull, brain, eye sockets, and sinuses.ImageRead Article Now Book Mark Article MRIA magnetic resonance imaging (MRI) scan is an imaging test that uses powerful magnets and radio waves to create pictures of the body. It does not us...ImageRead Article Now Book Mark Article Examination of the nervous system Treatment The goal of the treatment is to relieve symptoms. Usually, surgery has been the main treatment for craniopharyngioma. However, radiation treatment instead of surgery or along with a smaller surgery may be the best choice for some people.In tumors that cannot be removed completely with surgery alone, radiation therapy is used. If the tumor has a classic appearance on CT scan, a biopsy may not be needed if treatment with radiation alone is planned.Radiation therapyRadiation therapy uses high-powered radiation (such as x-rays or gamma rays), particles, or radioactive seeds to kill cancer cells.ImageRead Article Now Book Mark Article Stereotactic radiosurgery is performed at some medical centers.Stereotactic radiosurgeryStereotactic radiosurgery (SRS) is a form of radiation therapy that focuses high-power energy on a small area of the body. Despite its name, radiosu...Read Article Now Book Mark Article This tumor is best treated at a center with experience in treating craniopharyngiomas. Outlook (Prognosis) In general, the outlook is good. There is an 80% to 90% chance of a cure if the tumor can be completely removed with surgery or treated with high doses of radiation. If the tumor returns, it will most often come back within the first 2 years after surgery.Outlook depends on several factors, including:Whether the tumor can be completely removed Which nervous system problems and hormonal imbalances the tumor and treatment cause Most of the problems with hormones and vision do not improve with treatment. Sometimes, the treatment may even make them worse. Possible Complications There may be long-term hormone, vision, and nervous system problems after craniopharyngioma is treated.When the tumor is not completely removed, the condition may return. When to Contact a Medical Professional Call your provider for the following symptoms:Headache, nausea, vomiting, or balance problems (signs of increased pressure on the brain) Increased thirst and urination Poor growth in a child Vision changesOpen ReferencesReferencesStyne DM. Physiology and disorders of puberty. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 26.Suh JH, Chao ST, Murphy ES, Recinos PF. Pituitary tumors and craniopharyngiomas. In: Tepper JE, Foote RL, Michalski JM, eds. Gunderson & Tepper's Clinical Radiation Oncology. 5th ed. Philadelphia, PA: Elsevier; 2021:chap 34.Zaky W, Ater JL, Khatua S. Brain tumors in childhood. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 524.AllVideoImagesTogEndocrine glands - illustration Endocrine glands release hormones (chemical messengers) into the bloodstream to be transported to various organs and tissues throughout the body. For instance, the pancreas secretes insulin, which allows the body to regulate levels of sugar in the blood. The thyroid gets instructions from the pituitary to secrete hormones which determine the rate of metabolism in the body (the more hormone in the bloodstream, the faster the chemical activity; the less hormone, the slower the activity).Endocrine glandsillustrationEndocrine glands - illustration Endocrine glands release hormones (chemical messengers) into the bloodstream to be transported to various organs and tissues throughout the body. For instance, the pancreas secretes insulin, which allows the body to regulate levels of sugar in the blood. The thyroid gets instructions from the pituitary to secrete hormones which determine the rate of metabolism in the body (the more hormone in the bloodstream, the faster the chemical activity; the less hormone, the slower the activity).Endocrine glandsillustrationRelated Information Tumor(Condition)Endocrine glands(Special Topic) Review Date: 4/29/2022 Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. 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CraniopharyngiomaA craniopharyngioma is a noncancerous (benign) tumor that develops at the base of the brain near the pituitary gland.TumorA tumor is an abnormal growth of body tissue. Tumors can be cancerous (malignant) or noncancerous (benign).Read Article Now Book Mark Article Causes The exact cause of the tumor is unknown.This tumor most commonly affects children between 5 to 10 years of age. Adults can sometimes be affected. Boys and girls are equally likely to develop this tumor. Symptoms Craniopharyngioma causes symptoms by:Increasing pressure on the brain, usually from hydrocephalus HydrocephalusHydrocephalus is a buildup of fluid inside the skull that leads to the brain pushing against the skull. Hydrocephalus means "water on the brain. "...ImageRead Article Now Book Mark Article Disrupting hormone production by the pituitary gland Pressure or damage to the optic nerveDamage to the optic nerveOptic nerve atrophy is damage to the optic nerve. The optic nerve carries images of what the eye sees to the brain.ImageRead Article Now Book Mark Article Increased pressure on the brain can cause:Headache Nausea Vomiting (especially in the morning)Damage to the pituitary gland causes hormone imbalances that can lead to excessive thirst and urination, and slow growth.When the optic nerve is damaged by the tumor, vision problems develop. These defects are often permanent. They may get worse after surgery to remove the tumor.Behavioral and learning problems may be present. Exams and Tests Your health care provider will perform a physical exam. Tests will be done to check for a tumor. These may include:Blood tests to measure hormone levels CT scan or MRI scan of the brain CT scanA head computed tomography (CT) scan uses many x-rays to create pictures of the head, including the skull, brain, eye sockets, and sinuses.ImageRead Article Now Book Mark Article MRIA magnetic resonance imaging (MRI) scan is an imaging test that uses powerful magnets and radio waves to create pictures of the body. It does not us...ImageRead Article Now Book Mark Article Examination of the nervous system Treatment The goal of the treatment is to relieve symptoms. Usually, surgery has been the main treatment for craniopharyngioma. However, radiation treatment instead of surgery or along with a smaller surgery may be the best choice for some people.In tumors that cannot be removed completely with surgery alone, radiation therapy is used. If the tumor has a classic appearance on CT scan, a biopsy may not be needed if treatment with radiation alone is planned.Radiation therapyRadiation therapy uses high-powered radiation (such as x-rays or gamma rays), particles, or radioactive seeds to kill cancer cells.ImageRead Article Now Book Mark Article Stereotactic radiosurgery is performed at some medical centers.Stereotactic radiosurgeryStereotactic radiosurgery (SRS) is a form of radiation therapy that focuses high-power energy on a small area of the body. Despite its name, radiosu...Read Article Now Book Mark Article This tumor is best treated at a center with experience in treating craniopharyngiomas. Outlook (Prognosis) In general, the outlook is good. There is an 80% to 90% chance of a cure if the tumor can be completely removed with surgery or treated with high doses of radiation. If the tumor returns, it will most often come back within the first 2 years after surgery.Outlook depends on several factors, including:Whether the tumor can be completely removed Which nervous system problems and hormonal imbalances the tumor and treatment cause Most of the problems with hormones and vision do not improve with treatment. Sometimes, the treatment may even make them worse. Possible Complications There may be long-term hormone, vision, and nervous system problems after craniopharyngioma is treated.When the tumor is not completely removed, the condition may return. When to Contact a Medical Professional Call your provider for the following symptoms:Headache, nausea, vomiting, or balance problems (signs of increased pressure on the brain) Increased thirst and urination Poor growth in a child Vision changesOpen ReferencesReferencesStyne DM. Physiology and disorders of puberty. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 26.Suh JH, Chao ST, Murphy ES, Recinos PF. Pituitary tumors and craniopharyngiomas. In: Tepper JE, Foote RL, Michalski JM, eds. Gunderson & Tepper's Clinical Radiation Oncology. 5th ed. Philadelphia, PA: Elsevier; 2021:chap 34.Zaky W, Ater JL, Khatua S. Brain tumors in childhood. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 524.