Drug-induced diarrheaDiarrhea associated with medicines
Drug-induced diarrhea is loose, watery stools that occurs when you take certain medicines.
Diarrhea is when you have more than 3 very loose bowel movements in 1 day. For many, diarrhea is mild and will pass within a few days. For others, ...Read Article Now Book Mark Article
Nearly all medicines may cause diarrhea as a side effect. The drugs listed below, however, are more likely to cause diarrhea.
Laxatives are meant to cause diarrhea.
- They work either by drawing water into the gut or by causing the muscles of the intestines to contract.
- However, taking too much of a laxative can cause diarrhea that is a problem.
Antacids that have magnesium in them may also cause diarrhea or make it worse.
Antibiotics also can produce diarrhea.
- Normally, the intestines have many different bacteria. They keep each other in balance. Antibiotics destroy some of these bacteria, which allow other types to grow too much.
- In some cases, antibiotics can allow a type of bacteria called Clostridioides difficile to grow too much. This can lead to severe, watery, and often bloody diarrhea called pseudomembranous colitis.
Many other drugs may cause diarrhea:
- Chemotherapy medicines used to treat cancer.
- Drugs used to treat heartburn and stomach ulcers, such as omeprazole (Prilosec), esomeprazole (Nexium), lansoprazole (Prevacid), rabeprazole (AcipHex), pantoprazole (Protonix), cimetidine (Tagamet), ranitidine (Zantac), and nizatidine (Axid). This is uncommon.
- Medicines that suppress the immune system (such as mycophenolate).
- Nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain and arthritis, such as ibuprofen and naproxen.
- Metformin used to treat diabetes.
Some herbal teas contain senna or other "natural" laxatives that can cause diarrhea. Other vitamins, minerals, or supplements may also cause diarrhea.
To prevent diarrhea due to antibiotic use, talk to your health care provider about taking supplements containing healthy bacteria (probiotics) and/or eating yogurt. Some of these products may reduce the risk for diarrhea. Keep taking these supplements for a few days after you finish your antibiotics.
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Seller RH, Symons AB. Diarrhea. In: Seller RH, Symons AB, eds. Differential Diagnosis of Common Complaints. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 10.
Siddiqi HA, Salwen MJ, Shaikh MF, Bowne WB. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 22.
Digestive system organs - illustration
The digestive system organs in the abdominal cavity include the liver, gallbladder, stomach, small intestine and large intestine.
Digestive system organs
Review Date: 10/17/2019
Reviewed By: Michael M. Phillips, MD, Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.