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Whipple disease

Show Alternative Names
Intestinal lipodystrophy
Whipple's disease

Whipple disease is a rare condition that mainly affects the small intestine. This prevents the small intestine from allowing nutrients to pass into the rest of the body. This is called malabsorption.

Causes

Whipple disease is caused by infection with a bacterium called Tropheryma whipplei. The disorder mainly affects white men of middle-age.

Whipple disease is rare. Risk factors are not known.

Symptoms

Symptoms most often start slowly. Joint pain is the most common early symptom. Symptoms of gastrointestinal (GI) infection often occur several years later. Other symptoms may include:

Exams and Tests

The health care provider will perform a physical exam. This may show:

Tests to diagnose Whipple disease may include:

This disease may also change the results of the following tests:

  • Albumin levels in the blood
  • Unabsorbed fat in the stools (fecal fat)
  • Intestinal absorption of a type of sugar (d-xylose absorption)

Treatment

People with Whipple disease need to take long-term antibiotics to cure the infection that may include sites in the brain and central nervous system. An antibiotic called ceftriaxone is given through a vein (IV). It is followed by another antibiotic (such as trimethoprim-sulfamethoxazole) taken by mouth for up to 1 year.

If symptoms come back during antibiotic use, the medicines may be changed.

Your provider should closely follow your progress. Symptoms of the disease can return after you finish the treatments. People who remain malnourished will also need to take dietary supplements.

Outlook (Prognosis)

If not treated, the condition is most often fatal. Treatment relieves symptoms and can cure the disease.

Possible Complications

Complications may include:

  • Brain damage
  • Heart valve damage (from endocarditis)
  • Nutritional deficiencies
  • Symptoms return (which may be because of drug resistance)
  • Weight loss

When to Contact a Medical Professional

Contact your provider if you have:

  • Joint pain that does not go away
  • Abdominal pain
  • Diarrhea

If you are being treated for Whipple disease, contact your provider if:

  • Symptoms get worse or do not improve
  • Symptoms reappear
  • New symptoms develop
Review Date: 5/14/2024

Reviewed By

Jenifer K. Lehrer, MD, Department of Gastroenterology, Aria - Jefferson Health Torresdale, Jefferson Digestive Diseases Network, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

References

Maiwald M, von Herbay A, Relman DA. Whipple disease. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 109.

Marth T, Schneider T. Whipple disease. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 210.

West SG. Systemic diseases in which arthritis is a feature. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 254.

Disclaimer

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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