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Pharmacogenetics

PGx; Pharmacogenomics

Pharmacogenetics is the study of how genes affect the way medicines work in a person. Your health care provider can use the information from pharmacogenetic testing to prescribe medicines that will work best for you with fewer side effects.

Information

Pharmacogenetics is a type of precision medicine. Precision medicine uses information about a person's genes, environment, and lifestyle to help diagnose, prevent, and treat illness specifically for that person.

Pharmacogenetics uses information from your genes to see how your body will respond to a medicine. Your provider may order pharmacogenetic testing to see if you can take certain medicines safely and how well they will work.

Pharmacogenetic testing results identify changes in certain genes. These genes control your body's response to medicines. Using pharmacogenetic testing, your provider can find out:

  • Whether your body will have a strong, weak, or no response to a medicine
  • How quickly a medicine is taken up into the tissues and cells where it is needed
  • How quickly your body breaks down a medicine
  • The chance that a medicine will cause side effects

These results can help your provider know what medicine and dose will work to treat your condition. This can speed up the treatment process by avoiding trial-and-error dosing. Finding the right medicine can improve your health more quickly.

At this time, only certain medicines have this testing available. For example, it can be used in some cases for people taking medicine for:

Pharmacogenetics may help providers find the best medicines for the people who need them.

Open References

References

Centers for Disease Control and Prevention website. Pharmacogenomics: What does it mean for your health? www.cdc.gov/genomics/disease/pharma.htm. Updated May 20, 2022. Accessed May 1, 2023.

Korf BR, Limdi NA. Principles of genetics. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 31.

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        Review Date: 6/26/2023

        Reviewed By: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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