Protein-losing enteropathy is an abnormal loss of protein from the digestive tract. It can also refer to the inability of the digestive tract to absorb proteins.
There are many causes of protein-losing enteropathy. Conditions that cause serious inflammation in the intestines can lead to protein loss. Some of these are:
- Bacterial or parasitic infection of the intestines
- Celiac disease
- Crohn disease
- HIV infection
- Lymphatic obstruction in the gastrointestinal tract
- Intestinal lymphangiectasia
Symptoms can include:
- Abdominal pain
Symptoms will depend on the disease that is causing the problem.
Exams and Tests
You may need tests that look at the intestinal tract. These may include a CT scan of the abdomen or an upper GI bowel series.
Other tests you may need include:
- Esophagogastroduodenoscopy (EGD)
- Small intestine biopsy
- Alpha-1-antitrypsin test
- Small bowel capsule endoscopy
- CT or MR enterography
The health care provider will treat the condition that caused protein-losing enteropathy.
Greenwald DA. Protein losing gastroenteropathy. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 31.
Rej A, Chew TS, Sanders DS. Gastroenterology. In: Penman ID, Ralston SH, Strachan MWJ, Hobson RP, eds. Davidson's Principles and Practice of Medicine. 24th ed. Philadelphia, PA: Elsevier; 2023:chap 23.
Review Date: 7/30/2022
Reviewed By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.