BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuSmall bowel tissue smear/biopsySmall bowel tissue smear is a lab test that checks for disease in a sample of tissue from the small intestine. How the Test is Performed A sample of tissue from the small intestine is removed during a procedure called esophagogastroduodenoscopy (EGD) or another procedure called enteroscopy. A brushing of the intestine lining can also be taken.Tissue from the small intestine is remo...A biopsy is the removal of a small piece of tissue for laboratory examination.Read Article Now Book Mark Article Esophagogastroduodenoscopy (EGDEsophagogastroduodenoscopy (EGD) is a test to examine the lining of the esophagus, stomach, and first part of the small intestine (the duodenum)....ImageRead Article Now Book Mark Article The sample is sent to a laboratory. There it is sliced, stained, and placed on a microscope slide to be examined. How to Prepare for the Test You will need to have an EGD or enteroscopy procedure for the sample to be taken. Prepare for this procedure in the way your health care provider recommends. How the Test will Feel You are not involved in the test once the sample is taken. Why the Test is Performed Your provider may order this test to look for an infection or other disease of the small intestine. In most cases, this test is done only when a diagnosis could not be made using stool and blood tests. Normal Results A normal result means that there were no indicators of disease when the sample was examined under the microscope.The small intestine normally contains certain healthy bacteria and yeast. Their presence is not a sign of disease.Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results. What Abnormal Results Mean An abnormal result means that certain microorganisms, such as the parasites giardia or strongyloides were seen in the tissue sample. It may also mean that there were changes in the structure (anatomy) of the tissue.The biopsy may also reveal evidence of celiac disease, Whipple disease or Crohn disease. Risks There are no risks associated with a laboratory culture. The risks of the EGD or enteroscopy procedure include:Bleeding Perforation of (poking a hole in) the gastrointestinal tract by the scope InfectionSome people may not be able to have this test because of other medical conditions.Open ReferencesReferencesBush LM, Levison ME. Peritonitis and intraperitoneal abscesses. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 74.Mathison BA, Pritt BS. Medical parasitology. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 63.Ramakrishna BS. Tropical diarrhea and malabsorption. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 108.Siddiqi HA, Rabinowitz S, Axiotis CA. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 23.AllVideoImagesTogSmall intestine tissue sample - illustration A sample of small intestine is obtained by the use of a flexible scope that is passed through the digestive tract to the small intestine. In the small intestine, a small sample is removed and placed on a microscope slide. The sample is stained and sectioned (sliced) for histological (tissue) examination. The test is performed to diagnose an infection or parasitic infestation of the small bowel.Small intestine tissue sampleillustrationSmall intestine tissue sample - illustration A sample of small intestine is obtained by the use of a flexible scope that is passed through the digestive tract to the small intestine. In the small intestine, a small sample is removed and placed on a microscope slide. The sample is stained and sectioned (sliced) for histological (tissue) examination. The test is performed to diagnose an infection or parasitic infestation of the small bowel.Small intestine tissue sampleillustration Tests for Small bowel tissue smear/biopsy Small bowel tissue smear/biopsyEnteroscopySigmoidoscopyColonoscopyVirtual colonoscopyColposcopy - directed biopsyRelated Information String test(Medical Test)Giardia infection(Condition) Review Date: 5/6/2022 Reviewed By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. 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Small bowel tissue smear/biopsySmall bowel tissue smear is a lab test that checks for disease in a sample of tissue from the small intestine. How the Test is Performed A sample of tissue from the small intestine is removed during a procedure called esophagogastroduodenoscopy (EGD) or another procedure called enteroscopy. A brushing of the intestine lining can also be taken.Tissue from the small intestine is remo...A biopsy is the removal of a small piece of tissue for laboratory examination.Read Article Now Book Mark Article Esophagogastroduodenoscopy (EGDEsophagogastroduodenoscopy (EGD) is a test to examine the lining of the esophagus, stomach, and first part of the small intestine (the duodenum)....ImageRead Article Now Book Mark Article The sample is sent to a laboratory. There it is sliced, stained, and placed on a microscope slide to be examined. How to Prepare for the Test You will need to have an EGD or enteroscopy procedure for the sample to be taken. Prepare for this procedure in the way your health care provider recommends. How the Test will Feel You are not involved in the test once the sample is taken. Why the Test is Performed Your provider may order this test to look for an infection or other disease of the small intestine. In most cases, this test is done only when a diagnosis could not be made using stool and blood tests. Normal Results A normal result means that there were no indicators of disease when the sample was examined under the microscope.The small intestine normally contains certain healthy bacteria and yeast. Their presence is not a sign of disease.Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results. What Abnormal Results Mean An abnormal result means that certain microorganisms, such as the parasites giardia or strongyloides were seen in the tissue sample. It may also mean that there were changes in the structure (anatomy) of the tissue.The biopsy may also reveal evidence of celiac disease, Whipple disease or Crohn disease. Risks There are no risks associated with a laboratory culture. The risks of the EGD or enteroscopy procedure include:Bleeding Perforation of (poking a hole in) the gastrointestinal tract by the scope InfectionSome people may not be able to have this test because of other medical conditions.Open ReferencesReferencesBush LM, Levison ME. Peritonitis and intraperitoneal abscesses. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 74.Mathison BA, Pritt BS. Medical parasitology. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 63.Ramakrishna BS. Tropical diarrhea and malabsorption. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 108.Siddiqi HA, Rabinowitz S, Axiotis CA. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 23.