ESRErythrocyte sedimentation rate; Sed rate; Sedimentation rate
ESR stands for erythrocyte sedimentation rate. It is commonly called a "sed rate."
It is a test that indirectly measures how much inflammation is in the body.
How the Test is Performed
A blood sample is needed. Most of the time, blood is drawn from a vein located on the inside of the elbow or the back of the hand. The blood sample is sent to a lab.
Drawn from a vein
Venipuncture is the collection of blood from a vein. It is most often done for laboratory testing.Read Article Now Book Mark Article
The test measures how fast red blood cells (called erythrocytes) fall to the bottom of a tall, thin tube.
How to Prepare for the Test
There are no special steps needed to prepare for this test.
How the Test will Feel
You may feel slight pain or a sting when the needle is inserted. You may also feel some throbbing at the site after the blood is drawn.
Why the Test is Performed
Reasons why a "sed rate" may be done include:
- Unexplained fevers
- Certain types of arthritis
- Muscle symptoms
- Other vague symptoms that cannot be explained
This test may also be used to monitor whether an illness is responding to treatment.
This test can be used to monitor inflammatory diseases or cancer. It is not used to diagnose a specific disorder.
However, the test is useful for detecting and monitoring:
- Autoimmune disorders
- Bone infections
- Certain forms of arthritis
- Inflammatory diseases that cause vague symptoms
- Tissue death
For adults (Westergren method):
- Men under 50 years old: less than 15 mm/hr
- Men over 50 years old: less than 20 mm/hr
- Women under 50 years old: less than 20 mm/hr
- Women over 50 years old: less than 30 mm/hr
For children (Westergren method):
- Newborn: 0 to 2 mm/hr
- Newborn to puberty: 3 to 13 mm/hr
Note: mm/hr = millimeters per hour
Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.
What Abnormal Results Mean
An abnormal ESR may help with a diagnosis, but it does not prove that you have a certain condition. Other tests are almost always needed.
An increased ESR rate may be due to:
The immune system helps protect the body against harmful substances. An autoimmune disorder is when the immune system mistakenly attacks and destroys healthy body tissue. ESR is often higher than normal in people with an autoimmune disorder.
An autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. There are more than 80 types of aut...Read Article Now Book Mark Article
Common autoimmune disorders include:
- Rheumatoid arthritis in adults or children
Rheumatoid arthritis in adults
Rheumatoid arthritis (RA) is a disease that leads to inflammation of the joints and surrounding tissues. It is a long-term disease. It can also aff...Read Article Now Book Mark Article
Very high ESR levels occur with less common autoimmune disorders, including:
- Allergic vasculitis
- Giant cell arteritis
- Hyperfibrinogenemia (increased fibrinogen levels in the blood)
- Macroglobulinemia - primary
- Necrotizing vasculitis
- Polymyalgia rheumatica
An increased ESR rate may be due to some infections, including:
- Bodywide (systemic) infection
- Bone infections
- Infection of the heart or heart valves
- Rheumatic fever
- Severe skin infections, such as erysipelas
Lower-than-normal levels occur with:
- Congestive heart failure
- Hypofibrinogenemia (decreased fibrinogen levels)
- Low plasma protein (due to liver or kidney disease)
- Sickle cell anemia
Marshall SE. Immunological factors in disease. In: Walker BR, Colledge NR, Ralston SH, Penman ID, eds. Davidson's Principles and Practice of Medicine. 22nd ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2014:chap 4.
Pisetsky DS. Laboratory testing in the rheumatic diseases. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 257.
Review Date: 5/21/2017
Reviewed By: Laura J. Martin, MD, MPH, ABIM Board Certified in Internal Medicine and Hospice and Palliative Medicine, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.