BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuRPR testRapid plasma reagin test; Syphilis screening testRPR (rapid plasma reagin) is a screening test for syphilis. It measures substances (proteins) called antibodies that are present in the blood of people who may have the disease.SyphilisSyphilis is a bacterial infection that is most often spread through sexual contact.ImageRead Article Now Book Mark Article AntibodiesAn antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include micr...ImageRead Article Now Book Mark Article How the Test is Performed A blood sample is needed.Blood sample is neededVenipuncture is the collection of blood from a vein. It is most often done for laboratory testing.ImageRead Article Now Book Mark Article How to Prepare for the Test No special preparation is usually needed. How the Test will Feel When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away. Why the Test is Performed The RPR test can be used to screen for syphilis. It is used to screen people who have symptoms of sexually transmitted infections and is routinely used to screen pregnant women for the disease.The test is also used to see how treatment for syphilis is working. After treatment with antibiotics, the levels of syphilis antibodies should fall. These levels can be monitored with another RPR test. Unchanged or rising levels can mean a persistent infection.The test is similar to the venereal disease research laboratory (VDRL) test.Venereal disease research laboratoryThe VDRL test is a screening test for syphilis. It measures substances (proteins), called antibodies, which your body may produce if you have been i...ImageRead Article Now Book Mark Article Normal Results A negative test result is considered normal. However, the body does not always produce antibodies specifically in response to the syphilis bacteria, so the test is not always accurate. False-negatives may occur in people with early- and late-stage syphilis. More testing may be needed before ruling out syphilis. What Abnormal Results Mean A positive test result may mean that you have syphilis. If the screening test is positive, the next step is to confirm the diagnosis with a more specific test for syphilis, such as FTA-ABS. The FTA-ABS test will help distinguish between syphilis and other infections or conditions.FTA-ABSThe FTA-ABS test is used to detect antibodies to the bacteria Treponema pallidum, which causes syphilis.ImageRead Article Now Book Mark Article How well the RPR test can detect syphilis depends on the stage of the infection. The test is most sensitive (almost 100%) during the middle (secondary and latent) stages of syphilis. It is less sensitive during the early (primary) and late (tertiary) stages of the infection.Some conditions may cause a false-positive test, including:Lyme disease Lyme diseaseLyme disease is a bacterial infection that is spread through the bite of one of several types of ticks.ImageRead Article Now Book Mark Article Certain types of pneumonia Malaria MalariaMalaria is a parasitic disease that involves high fevers, shaking chills, flu-like symptoms, and anemia.ImageRead Article Now Book Mark Article Pregnancy Systemic lupus erythematosus and some other autoimmune disorders Systemic lupus erythematosusSystemic lupus erythematosus (SLE) is an autoimmune disease. In this disease, the immune system of the body mistakenly attacks healthy tissue. It c...ImageRead Article Now Book Mark Article Tuberculosis (TB) Risks There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight, but may include:Excessive bleeding Fainting or feeling lightheaded Multiple punctures to locate veins Hematoma (blood accumulating under the skin) Infection (a slight risk any time the skin is broken)Open ReferencesReferencesRadolf JD, Tramont EC, Salazar JC. Syphilis (Treponema pallidum). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 237.US Preventive Services Task Force; Mangione CM, Barry MJ, et al. Screening for syphilis infection in nonpregnant adolescents and adults: US Preventive Services Task Force Reaffirmation Recommendation Statement. JAMA. 2022;328(12):1243-1249. PMID: 36166020 pubmed.ncbi.nlm.nih.gov/36166020/.AllVideoImagesTogBlood test - illustration Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.Blood testillustrationBlood test - illustration Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.Blood testillustration Tests for RPR test RPR testVDRL testRelated Information VDRL test(Medical Test)FTA-ABS blood test(Medical Test) Review Date: 8/26/2023 Reviewed By: Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited. © 1997- All rights reserved. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.Content is best viewed in IE9 or above, Firefox and Google Chrome browser.
RPR testRapid plasma reagin test; Syphilis screening testRPR (rapid plasma reagin) is a screening test for syphilis. It measures substances (proteins) called antibodies that are present in the blood of people who may have the disease.SyphilisSyphilis is a bacterial infection that is most often spread through sexual contact.ImageRead Article Now Book Mark Article AntibodiesAn antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include micr...ImageRead Article Now Book Mark Article How the Test is Performed A blood sample is needed.Blood sample is neededVenipuncture is the collection of blood from a vein. It is most often done for laboratory testing.ImageRead Article Now Book Mark Article How to Prepare for the Test No special preparation is usually needed. How the Test will Feel When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away. Why the Test is Performed The RPR test can be used to screen for syphilis. It is used to screen people who have symptoms of sexually transmitted infections and is routinely used to screen pregnant women for the disease.The test is also used to see how treatment for syphilis is working. After treatment with antibiotics, the levels of syphilis antibodies should fall. These levels can be monitored with another RPR test. Unchanged or rising levels can mean a persistent infection.The test is similar to the venereal disease research laboratory (VDRL) test.Venereal disease research laboratoryThe VDRL test is a screening test for syphilis. It measures substances (proteins), called antibodies, which your body may produce if you have been i...ImageRead Article Now Book Mark Article Normal Results A negative test result is considered normal. However, the body does not always produce antibodies specifically in response to the syphilis bacteria, so the test is not always accurate. False-negatives may occur in people with early- and late-stage syphilis. More testing may be needed before ruling out syphilis. What Abnormal Results Mean A positive test result may mean that you have syphilis. If the screening test is positive, the next step is to confirm the diagnosis with a more specific test for syphilis, such as FTA-ABS. The FTA-ABS test will help distinguish between syphilis and other infections or conditions.FTA-ABSThe FTA-ABS test is used to detect antibodies to the bacteria Treponema pallidum, which causes syphilis.ImageRead Article Now Book Mark Article How well the RPR test can detect syphilis depends on the stage of the infection. The test is most sensitive (almost 100%) during the middle (secondary and latent) stages of syphilis. It is less sensitive during the early (primary) and late (tertiary) stages of the infection.Some conditions may cause a false-positive test, including:Lyme disease Lyme diseaseLyme disease is a bacterial infection that is spread through the bite of one of several types of ticks.ImageRead Article Now Book Mark Article Certain types of pneumonia Malaria MalariaMalaria is a parasitic disease that involves high fevers, shaking chills, flu-like symptoms, and anemia.ImageRead Article Now Book Mark Article Pregnancy Systemic lupus erythematosus and some other autoimmune disorders Systemic lupus erythematosusSystemic lupus erythematosus (SLE) is an autoimmune disease. In this disease, the immune system of the body mistakenly attacks healthy tissue. It c...ImageRead Article Now Book Mark Article Tuberculosis (TB) Risks There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight, but may include:Excessive bleeding Fainting or feeling lightheaded Multiple punctures to locate veins Hematoma (blood accumulating under the skin) Infection (a slight risk any time the skin is broken)Open ReferencesReferencesRadolf JD, Tramont EC, Salazar JC. Syphilis (Treponema pallidum). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 237.US Preventive Services Task Force; Mangione CM, Barry MJ, et al. Screening for syphilis infection in nonpregnant adolescents and adults: US Preventive Services Task Force Reaffirmation Recommendation Statement. JAMA. 2022;328(12):1243-1249. PMID: 36166020 pubmed.ncbi.nlm.nih.gov/36166020/.