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Pyruvate kinase blood test

The pyruvate kinase test measures the level of pyruvate kinase enzyme in the blood.

Pyruvate kinase is an enzyme found in red blood cells. It helps change sugar in the blood (glucose) to energy when oxygen levels are low.

How the Test is Performed

A blood sample is needed. In the laboratory, white blood cells are removed from the blood sample because they can alter test results. The level of pyruvate kinase is then measured.

How to Prepare for the Test

No special preparation is necessary.

If your child is having this test, it may help to explain how the test will feel and even demonstrate on a doll. Explain the reason for the test. Knowing the how and why may reduce your child's anxiety.

How the Test will Feel

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

Why the Test is Performed

This test is done to detect an abnormally low level of pyruvate kinase. Without enough of this enzyme, red blood cells break down faster than normal. This is called hemolytic anemia.

This test helps diagnose pyruvate kinase deficiency (PKD).

Normal Results

Results vary depending on the testing method used. In general, a normal value is 5.5 to 12.4 U/g Hb.

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your health care provider about the meaning of your specific test results.

What Abnormal Results Mean

A low level of pyruvate kinase confirms PKD.

Risks

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight, but may include:

  • Excessive bleeding
  • Fainting or feeling lightheaded
  • Multiple punctures to locate veins
  • Hematoma (blood buildup under the skin)
  • Infection (a slight risk any time the skin is broken)
Review Date: 3/31/2024

Reviewed By

Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

References

Elghetany MT, Banki K. Erythrocytic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 33.

Gallagher PG. Hemolytic anemias: red cell membrane and metabolic defects. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 147.

Papachristodoulou D. Energy metabolism. In: Naish J, Syndercombe Court D, eds. Medical Sciences. 3rd ed. Philadelphia, PA: Elsevier; 2019:chap 3.

Rab MAE, van Wijk R. Enzymes of the red blood cell. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Philadelphia, PA: Elsevier; 2023:chap 78.

Disclaimer

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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