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Meclofenamate overdose

Meclofenamate is a nonsteroidal anti-inflammatory drug (NSAID) used to treat arthritis. Meclofenamate overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose.

This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with has an overdose, call your local emergency number (such as 911), or your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.

Poisonous Ingredient

Meclofenamate can be harmful in large amounts.

Symptoms

Below are symptoms of a meclofenamate overdose in different parts of the body. 

EYES, EARS, NOSE, AND THROAT

HEART AND BLOOD

  • Congestive heart failure (chest discomfort, shortness of breath, leg swelling)
  • High or low blood pressure

KIDNEYS

  • Decreased urine output
  • No urine output

LUNGS AND AIRWAYS

  • Difficulty breathing
  • Wheezing

NERVOUS SYSTEM

  • Headache
  • Agitation
  • Coma (decreased level of consciousness and lack of responsiveness)
  • Confusion
  • Convulsions
  • Drowsiness
  • Fatigue and weakness
  • Numbness and tingling
  • Seizures
  • Unsteadiness

SKIN

  • Blistering rash
  • Bruising
  • Sweating

STOMACH AND INTESTINES

Home Care

Seek medical help right away. DO NOT make the person throw up unless poison control or a health care provider tells you to.

Before Calling Emergency

Have this information ready:

  • Person's age, weight, and condition
  • Name of the product (and ingredients and strength, if known)
  • Time it was swallowed
  • Amount swallowed
  • If the medicine was prescribed for the person

Poison Control

Your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

What to Expect at the Emergency Room

Take the container to the hospital with you, if possible.

The provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure.

Tests that may be done include:

  • Blood and urine tests
  • Chest x-ray
  • ECG (electrocardiogram, or heart tracing)

Treatment may include:

  • Fluids through a vein (by IV)
  • Medicine to treat stomach inflammation and bleeding, breathing problems, and other symptoms
  • Activated charcoal
  • Laxative
  • Tube through the mouth into the stomach if vomiting contains blood
  • Breathing support, including tube through the mouth into the lungs and connected to a breathing machine (ventilator)

Outlook (Prognosis)

How well someone does depends on how much meclofenamate was swallowed and how quickly treatment is received. The faster medical help is given, the better the chance for recovery.

This type of overdose does not usually cause serious problems. The person may have some stomach pain and vomiting (possibly with blood). However, serious side effects can occur. Severe internal bleeding is possible, and a blood transfusion may be needed. A procedure called an endoscopy may be required to stop internal bleeding. In this procedure, a tube with a camera on it is passed through the mouth into the stomach.

If kidney damage is severe, dialysis may be needed until kidney function returns. In some cases, the damage is permanent.

A large overdose can cause serious damage to children and adults. Death may occur.

Open References

References

Aronson JK. Non-steroidal anti-inflammatory drugs (NSAIDs). In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:236-272.

Hatten BW. Aspirin and nonsteroidal agents. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 144.

 

Review Date: 10/3/2019

Reviewed By: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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