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Lymph system

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Lymphatic system

The lymph system is a network of organs, lymph nodes, lymph ducts, and lymph vessels that make and move lymph from tissues to the bloodstream. The lymph system is a major part of the body's immune system.

Lymphatics and the breast - Animation

The lymphatic system is often referred to as the body's secondary circulatory system. The lymphatic system collects excess fluid in the body's tissues and returns it to the bloodstream. Lymph formation occurs at the microscopic level. During the exchange of fluid and molecules between the blood circulation and body tissues, blood capillaries may not reabsorb all of the fluid. Surrounding lymphatic capillaries absorb the excess fluid. The fluid is then filtered and transported back by the lymphatic system into large veins near the heart. The lymphatic system can play a very worrisome role in the spread of breast cancer. Components of the lymphatic system called lymph nodes are distributed at specific locations throughout the body. There is also an extensive network of lymphatic vessels in every woman's breast tissue, which is important in regulating the local fluid balance as well as in filtering out harmful substances. The lymph vessels in the breast may inadvertently supply cancerous cells with access to a highway along which the cancerous cells can move to other parts of the body. This process is called metastasis and may result in the formation of a secondary cancer mass in a different location of the body. Regular breast self examinations can help to detect tumors earlier in their growth, hopefully before they spread quickly or metastasize.

Information

Lymph is a clear-to-white fluid made of:

  • White blood cells, especially lymphocytes, the cells that attack bacteria in the blood and body tissues
  • Fluid from the intestines called chyle, which contains proteins and fats

Lymph nodes are soft, small, round- or bean-shaped structures. They usually cannot be seen or easily felt. They are located in clusters in various parts of the body, such as the:

  • Neck
  • Armpit
  • Groin
  • Inside the center of the chest and abdomen

Lymph nodes - Animation

The lymphatic system is a complex network of thin vessels, valves, ducts, nodes, and organs. It helps to protect and maintain the fluid environment of the body by producing, filtering, and conveying lymph and by producing various blood cells. Lymph nodes play an important part in the body's defense against infection. The most common cause of swollen lymph nodes is infection, which might occur even if the infection is trivial or not. Afferent lymph vessels bring unfiltered fluids into the lymph node to be filtered while efferent vessels carry clean fluids away from the lymph node and to the cardiovascular system where it helps form the plasma in the blood. Overall, lymph nodes work like a biological filtering system. When the body is invaded by foreign organisms, the painful swelling sometimes felt in the neck, armpits, groin, or tonsils comes from the microorganisms being trapped inside collections of lymph cells or nodes. Eventually, these organisms are destroyed and eliminated by cells that line the walls of the lymph nodes and the swelling and pain subside.

Lymph nodes mainly store immune cells that help the body fight infection but are also places where these cells can be made. They also filter the lymph fluid and remove foreign material such as bacteria and cancer cells. When bacteria are recognized in the lymph fluid, the lymph nodes make more infection-fighting white blood cells. This causes the nodes to swell. The swollen nodes are sometimes felt in the neck, under the arms, and groin.

The lymph system includes the:

  • Tonsils
  • Adenoids
  • Spleen
  • Thymus
Review Date: 7/25/2022

Reviewed By

Linda J. Vorvick, MD, Clinical Professor, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

References

Ball JW, Dains JE, Flynn JA, Solomon BS, Stewart RW. Lymphatic system. In: Ball JW, Dains JE, Flynn JA, Solomon BS, Stewart RW, eds. Seidel's Guide to Physical Examination. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 10.

Hall JE, Hall ME. The microcirculation and lymphatic system: capillary fluid exchange, interstitial fluid, and lymph flow. In: Hall JE, Hall ME, eds. Guyton and Hall Textbook of Medical Physiology. 14th ed. Philadelphia, PA: Elsevier; 2021:chap 16.

Disclaimer

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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Lymph nodes - Animation

The lymphatic system has two main functions. Its network of vessels, valves, ducts, nodes, and organs helps balance the body's fluid by draining excess fluid, known as lymph, from the body's tissue and returning it to the blood after filtering it. Some types of blood cells are also made in the lymph nodes.

The lymphatic system also plays an important role in the body's immune system. Infection, even a trivial infection is, the most common cause of swollen lymph nodes.

Let's look at a cut section of a lymph node to see what happens.

Afferent means towards. Afferent lymph vessels bring unfiltered fluids from the body into the lymph node where they are filtered.

Efferent vessels, meaning away from, carry the clean fluid away and back to the bloodstream where it helps form plasma.

When the body is invaded by foreign organisms, the swelling sometimes felt in the neck, armpits, groin, or tonsils comes from the microorganisms trapped inside the lymph nodes.

Eventually, these organisms are destroyed and eliminated by cells that line the node walls. Then the swelling and pain subside.

 

Lymphatics and the breast - Animation

The body is mostly composed of fluids. All its cells contain and are surrounded by fluids. In addition, four to five liters of blood circulate through the cardiovascular system at any given time. Some of that blood escapes from the system as it passes through tiny blood vessels called capillaries in the body tissues. Fortunately, there is a "secondary circulatory system" that reabsorbs escaped fluid and returns it to the veins.

That system is the lymphatic system. It runs parallel to the veins and empties into them. Lymph forms at the microscopic level. Small arteries, or arterioles, lead to capillaries, which in turn lead to small veins, or venules. Lymph capillaries lie close to the blood capillaries, but they are not actually connected. The arterioles deliver blood to the capillaries from the heart, and the venules take blood away from the capillaries. As blood flows through the capillaries it is under pressure. This is called hydrostatic pressure. This pressure forces some of the fluid in the blood out of the capillary into surrounding tissue. Oxygen from the red blood cells, and nutrients in the fluid then diffuse into the tissue.

Carbon dioxide and cellular waste products in the tissue diffuse back into the bloodstream. The capillaries reabsorb most of the fluid. The lymph capillaries absorb what fluid is left.

Edema, or swelling, occurs when fluid in or between the cells leaks into the body tissues. It is caused by events that increase the flow of fluid out of the bloodstream or prevent its return. Persistent edema may be a sign of serious health problems and should be checked by a health care professional.

The lymphatic system can play a very worrisome role in the spread of breast cancer.

Lymph nodes filter the lymph as it passes through the system. They are located at specific points throughout the body such as in the armpits and high in the throat.

Lymphatic circulation in breast tissue helps regulate the local fluid balance as well as filter out harmful substances. But the breast's lymphatic system can also spread diseases such as cancer through the body.

Lymphatic vessels provide a highway along which invasive cancerous cells move to other parts of the body.

The process is called metastasis. It can lead to the formation of a secondary cancer mass in another part of the body.

This mammogram shows a tumor and the lymph vessel network it has invaded.

No woman is too young to know that regular breast self-examinations can help to catch tumors earlier in their growth, hopefully before they spread or metastasize.

 

Lymph nodes - Animation

The lymphatic system has two main functions. Its network of vessels, valves, ducts, nodes, and organs helps balance the body's fluid by draining excess fluid, known as lymph, from the body's tissue and returning it to the blood after filtering it. Some types of blood cells are also made in the lymph nodes.

The lymphatic system also plays an important role in the body's immune system. Infection, even a trivial infection is, the most common cause of swollen lymph nodes.

Let's look at a cut section of a lymph node to see what happens.

Afferent means towards. Afferent lymph vessels bring unfiltered fluids from the body into the lymph node where they are filtered.

Efferent vessels, meaning away from, carry the clean fluid away and back to the bloodstream where it helps form plasma.

When the body is invaded by foreign organisms, the swelling sometimes felt in the neck, armpits, groin, or tonsils comes from the microorganisms trapped inside the lymph nodes.

Eventually, these organisms are destroyed and eliminated by cells that line the node walls. Then the swelling and pain subside.

 

Lymphatics and the breast - Animation

The body is mostly composed of fluids. All its cells contain and are surrounded by fluids. In addition, four to five liters of blood circulate through the cardiovascular system at any given time. Some of that blood escapes from the system as it passes through tiny blood vessels called capillaries in the body tissues. Fortunately, there is a "secondary circulatory system" that reabsorbs escaped fluid and returns it to the veins.

That system is the lymphatic system. It runs parallel to the veins and empties into them. Lymph forms at the microscopic level. Small arteries, or arterioles, lead to capillaries, which in turn lead to small veins, or venules. Lymph capillaries lie close to the blood capillaries, but they are not actually connected. The arterioles deliver blood to the capillaries from the heart, and the venules take blood away from the capillaries. As blood flows through the capillaries it is under pressure. This is called hydrostatic pressure. This pressure forces some of the fluid in the blood out of the capillary into surrounding tissue. Oxygen from the red blood cells, and nutrients in the fluid then diffuse into the tissue.

Carbon dioxide and cellular waste products in the tissue diffuse back into the bloodstream. The capillaries reabsorb most of the fluid. The lymph capillaries absorb what fluid is left.

Edema, or swelling, occurs when fluid in or between the cells leaks into the body tissues. It is caused by events that increase the flow of fluid out of the bloodstream or prevent its return. Persistent edema may be a sign of serious health problems and should be checked by a health care professional.

The lymphatic system can play a very worrisome role in the spread of breast cancer.

Lymph nodes filter the lymph as it passes through the system. They are located at specific points throughout the body such as in the armpits and high in the throat.

Lymphatic circulation in breast tissue helps regulate the local fluid balance as well as filter out harmful substances. But the breast's lymphatic system can also spread diseases such as cancer through the body.

Lymphatic vessels provide a highway along which invasive cancerous cells move to other parts of the body.

The process is called metastasis. It can lead to the formation of a secondary cancer mass in another part of the body.

This mammogram shows a tumor and the lymph vessel network it has invaded.

No woman is too young to know that regular breast self-examinations can help to catch tumors earlier in their growth, hopefully before they spread or metastasize.

 
 
 
 

 

 
 

 
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