ChoriocarcinomaChorioblastoma; Trophoblastic tumor; Chorioepithelioma; Gestational trophoblastic neoplasia; Cancer - choriocarcinoma
Choriocarcinoma is a fast-growing cancer that occurs in a woman's uterus (womb). The abnormal cells start in the tissue that would normally become the placenta. This is the organ that develops during pregnancy to feed the fetus.
Choriocarcinoma is a type of gestational trophoblastic disease.
Gestational trophoblastic disease
Gestational trophoblastic disease (GTD) is a group of pregnancy-related conditions that develop inside a woman's uterus (womb). The abnormal cells s...Read Article Now Book Mark Article
Choriocarcinoma is a rare cancer that occurs as an abnormal pregnancy. A baby may or may not develop in this type of pregnancy.
The cancer may also occur after a normal pregnancy. But it most often occurs with a complete hydatidiform mole. This is a growth that forms inside the womb at the beginning of a pregnancy. The abnormal tissue from the mole can continue to grow even after attempted removal, and can become cancerous. About one half of all women with a choriocarcinoma had a hydatidiform mole, or molar pregnancy.
Hydatidiform mole (HM) is a rare mass or growth that forms inside the womb (uterus) at the beginning of a pregnancy. It is a type of gestational tro...Read Article Now Book Mark Article
An ectopic pregnancy is a pregnancy that occurs outside the womb (uterus). It may be fatal to the mother.Read Article Now Book Mark Article
A tumor is an abnormal growth of body tissue. Tumors can be cancerous (malignant) or noncancerous (benign).Read Article Now Book Mark Article
A possible symptom is abnormal or irregular vaginal bleeding in a woman who recently had a hydatidiform mole or pregnancy.
This article discusses vaginal bleeding that occurs between a woman's monthly menstrual periods. Such bleeding may be called "intermenstrual bleedin...Read Article Now Book Mark Article
Other symptoms may include:
- Irregular vaginal bleeding
- Pain, which may be associated with the bleeding, or due to enlargement of the ovaries that often occurs with a choriocarcinoma
Exams and Tests
A pregnancy test will be positive, even if you are not pregnant. The pregnancy hormone (HCG) level will be high.
A pelvic exam may find an enlarged uterus and ovaries.
Blood tests that may be done include:
Imaging tests that may be done include:
- CT scan
- Pelvic ultrasound
- Chest x-ray
You should be carefully monitored after a hydatidiform mole or at the end of a pregnancy. Early diagnosis of choriocarcinoma can improve the outcome.
After you are diagnosed, a careful history and exam will be done to make sure the cancer has not spread to other organs. Chemotherapy is the main type of treatment.
The term chemotherapy is used to describe cancer-killing drugs. Chemotherapy may be used to:Cure the cancer Shrink the cancerPrevent the cancer from...Read Article Now Book Mark Article
Hysterectomy to remove the womb and radiation treatment are rarely needed.
Hysterectomy is surgery to remove a woman's womb (uterus). The uterus is a hollow muscular organ that nourishes the developing baby during pregnancy...Read Article Now Book Mark Article
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.
Cancer support group
The following organizations are good resources for information on cancer:American Cancer Society -- www. cancer. orgAmerican Childhood Cancer Organiz...Read Article Now Book Mark Article
Most women whose cancer has not spread can be cured and will still be able to have children. A choriocarcinoma may come back within a few months to 3 years after treatment.
The condition is harder to cure if the cancer has spread and one or more of the following happens:
- Disease spreads to the liver or brain
- Pregnancy hormone (HCG) level is higher than 40,000 mIU/mL when treatment begins
- Cancer returns after having chemotherapy
- Symptoms or pregnancy occurred for more than 4 months before treatment began
- Choriocarcinoma occurred after a pregnancy that resulted in the birth of a child
Many women (about 70%) who have a poor outlook at first go into remission (a disease-free state).
When to Contact a Medical Professional
Call for an appointment with your health care provider if you develop symptoms within 1 year after a hydatidiform mole or pregnancy.
National Cancer Institute website. Gestational trophoblastic disease treatment (PDQ) – health professional version. www.cancer.gov/cancertopics/pdq/treatment/gestationaltrophoblastic/HealthProfessional. Updated December 17, 2019. Accessed June 25, 2020.
Salani R, Bixel K, Copeland LJ. Malignant diseases and pregnancy. In: Landon MB, Galan HL, Jauniaux ERM, et al, eds. Gabbe's Obstetrics: Normal and Problem Pregnancies. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 55.
Review Date: 6/8/2020
Reviewed By: LaQuita Martinez, MD, Department of Obstetrics and Gynecology, Emory Johns Creek Hospital, Alpharetta, GA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.