BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuGlanzmann thrombastheniaGlanzmann's disease; Thrombasthenia - GlanzmannGlanzmann thrombasthenia is a rare disorder of blood platelets. Platelets are particles in the blood that aid in blood clotting. Causes Glanzmann thrombasthenia is caused by the lack of a protein that is normally on the surface of platelets. This substance is needed for platelets to clump together to plug up bleeding spots and begin forming a clot.The condition is congenital, which means it is present from birth. There are several genetic abnormalities that can cause the condition. Symptoms Symptoms may include any of the following:Heavy bleeding during and after surgery Bleeding gums Bruising easily or pinpoint red spots on the skin Heavy menstrual bleeding Nosebleeds that do not stop easily Prolonged bleeding with minor injuries Exams and Tests The following tests may be used to diagnose this condition:Complete blood count (CBC) Complete blood countA complete blood count (CBC) test measures the following:The number of white blood cells (WBC count)The number of red blood cells (RBC count)The numb...Read Article Now Book Mark Article Platelet aggregation test Platelet aggregation testThe platelet aggregation blood test checks how well platelets, a part of blood, clump together and cause blood to clot.Read Article Now Book Mark Article Platelet function analysis (PFA) Prothrombin time (PT) and partial thromboplastin time (PTT) Prothrombin timeProthrombin time (PT) is a blood test that measures the time it takes for the liquid portion (plasma) of your blood to clot. It measures the functio...Read Article Now Book Mark Article Partial thromboplastin timePartial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. It can help tell if you have a bleeding problem...Read Article Now Book Mark Article Other tests may be needed. Family members may also need to be tested. Treatment There is no specific treatment for this disorder. Platelet transfusions may be given to people who are having severe bleeding. Support Groups More information and support for people with Glanzmann thrombasthenia and their families can be found at:Genetic and Rare Diseases Information Center (GARD) -- rarediseases.info.nih.gov/diseases/2478/glanzmann-thrombasthenia National Organization for Rare Disorders (NORD) -- rarediseases.org/rare-diseases/glanzmann-thrombasthenia/ Outlook (Prognosis) Glanzmann thrombasthenia is a lifelong condition, and there is no cure. You should take special steps to try to avoid bleeding if you have this condition. Anyone with a bleeding disorder should avoid taking aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen. These drugs can prolong bleeding times by preventing platelets from clumping. Possible Complications Complications may include:Severe bleeding Iron deficiency anemia in menstruating women due to abnormally heavy bleeding Iron deficiency anemiaAnemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues. There are man...Read Article Now Book Mark Article When to Contact a Medical Professional Contact your health care provider if:You have bleeding or bruising of an unknown cause Bleeding does not stop after usual treatments Prevention Glanzmann thrombasthenia is an inherited condition. There is no known prevention.Open ReferencesReferencesNeff AT. Von Willebrand disease and hemorrhagic abnormalities of platelet and vascular function. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 164.Samji N, Chan A, Bhatt MD. Bleeding and clotting disorders in pediatrics. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 148.AllVideoImagesTogRelated Information Platelet count(Medical Test)Bleeding into the skin(Symptoms)Nosebleed (Symptoms) Review Date: 2/2/2023 Reviewed By: Mark Levin, MD, Hematologist and Oncologist, Monsey, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. 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Glanzmann thrombastheniaGlanzmann's disease; Thrombasthenia - GlanzmannGlanzmann thrombasthenia is a rare disorder of blood platelets. Platelets are particles in the blood that aid in blood clotting. Causes Glanzmann thrombasthenia is caused by the lack of a protein that is normally on the surface of platelets. This substance is needed for platelets to clump together to plug up bleeding spots and begin forming a clot.The condition is congenital, which means it is present from birth. There are several genetic abnormalities that can cause the condition. Symptoms Symptoms may include any of the following:Heavy bleeding during and after surgery Bleeding gums Bruising easily or pinpoint red spots on the skin Heavy menstrual bleeding Nosebleeds that do not stop easily Prolonged bleeding with minor injuries Exams and Tests The following tests may be used to diagnose this condition:Complete blood count (CBC) Complete blood countA complete blood count (CBC) test measures the following:The number of white blood cells (WBC count)The number of red blood cells (RBC count)The numb...Read Article Now Book Mark Article Platelet aggregation test Platelet aggregation testThe platelet aggregation blood test checks how well platelets, a part of blood, clump together and cause blood to clot.Read Article Now Book Mark Article Platelet function analysis (PFA) Prothrombin time (PT) and partial thromboplastin time (PTT) Prothrombin timeProthrombin time (PT) is a blood test that measures the time it takes for the liquid portion (plasma) of your blood to clot. It measures the functio...Read Article Now Book Mark Article Partial thromboplastin timePartial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. It can help tell if you have a bleeding problem...Read Article Now Book Mark Article Other tests may be needed. Family members may also need to be tested. Treatment There is no specific treatment for this disorder. Platelet transfusions may be given to people who are having severe bleeding. Support Groups More information and support for people with Glanzmann thrombasthenia and their families can be found at:Genetic and Rare Diseases Information Center (GARD) -- rarediseases.info.nih.gov/diseases/2478/glanzmann-thrombasthenia National Organization for Rare Disorders (NORD) -- rarediseases.org/rare-diseases/glanzmann-thrombasthenia/ Outlook (Prognosis) Glanzmann thrombasthenia is a lifelong condition, and there is no cure. You should take special steps to try to avoid bleeding if you have this condition. Anyone with a bleeding disorder should avoid taking aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen. These drugs can prolong bleeding times by preventing platelets from clumping. Possible Complications Complications may include:Severe bleeding Iron deficiency anemia in menstruating women due to abnormally heavy bleeding Iron deficiency anemiaAnemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues. There are man...Read Article Now Book Mark Article When to Contact a Medical Professional Contact your health care provider if:You have bleeding or bruising of an unknown cause Bleeding does not stop after usual treatments Prevention Glanzmann thrombasthenia is an inherited condition. There is no known prevention.Open ReferencesReferencesNeff AT. Von Willebrand disease and hemorrhagic abnormalities of platelet and vascular function. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 164.Samji N, Chan A, Bhatt MD. Bleeding and clotting disorders in pediatrics. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 148.