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Hairy cell leukemia

Leukemic reticuloendotheliosis; HCL; Leukemia - hairy cell

Hairy cell leukemia (HCL) is an unusual cancer of the blood. It affects B lymphocyte cells, a type of white blood cell.

Causes

HCL is caused by the abnormal growth of certain B cells. The cells look "hairy" under the microscope because they have fine projections extending from their surface.

HCL usually leads to a low number of normal blood cells.

The cause of this disease is unknown. Certain genetic changes in the cancer cells may be the cause. It affects men more often than women. The average age of diagnosis is 55.

Symptoms

Symptoms of HCL may include any of the following:

Exams and Tests

During a physical exam, your health care provider may be able to feel a swollen spleen or liver. An abdominal CT scan or ultrasound may be done to evaluate this swelling.

Blood tests that may be done include:

  • Complete blood count (CBC) to check low levels of white and red blood cells, as well as platelets.
  • Blood tests and a bone marrow biopsy to check for hairy cells.

Treatment

Treatment may not be needed for the early stages of this disease. Some people may need an occasional blood transfusion.

If treatment is needed because of very low blood counts, chemotherapy medicines can be used.

In most cases, chemotherapy can relieve the symptoms for many years. When the signs and symptoms go away, you are said to be in remission.

Removing the spleen may improve blood counts, but is unlikely to cure the disease. Antibiotics can be used to treat infections. People with low blood counts may receive growth factors and, possibly, transfusions.

Outlook (Prognosis)

Most people with HCL can expect to live 10 years or longer after diagnosis and treatment.

Possible Complications

The low blood counts caused by hairy cell leukemia can lead to:

  • Infections
  • Fatigue
  • Excessive bleeding

When to Contact a Medical Professional

Contact your provider if you have major bleeding. Also contact your provider if you have signs of infection, such as a persistent fever, cough, or general ill feeling.

Prevention

There is no known way to prevent this disease.

References

National Cancer Institute website. Hairy cell leukemia treatment (PDQ) health professional version. www.cancer.gov/types/leukemia/hp/hairy-cell-treatment-pdq. Updated September 20, 2024. Accessed December 3, 2024.

Nasr MR, Hutchison RE. Leukocytic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 34.

Ravandi F. Hairy cell leukemia. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 77.

  • Bone marrow aspiration - illustration

    A small amount of bone marrow is removed during a bone marrow aspiration. The procedure is uncomfortable, but can be tolerated by both children and adults. The marrow can be studied to determine the cause of anemia, the presence of leukemia or other malignancy, or the presence of some storage diseases, in which abnormal metabolic products are stored in certain bone marrow cells.

    Bone marrow aspiration

    illustration

  • Hairy cell leukemia - microscopic view - illustration

    All the cells in this field are hairy cells. The cell membranes appear irregular and serrated. The cytoplasm stains light blue (black arrows). The nuclei tend to be irregular (red arrows).

    Hairy cell leukemia - microscopic view

    illustration

  • Enlarged spleen - illustration

    Because of its wide variety of functions, the spleen may be affected by many conditions involving the blood or lymph system, and by infection, malignancies, liver disease, and parasites.

    Enlarged spleen

    illustration

  • Bone marrow aspiration - illustration

    A small amount of bone marrow is removed during a bone marrow aspiration. The procedure is uncomfortable, but can be tolerated by both children and adults. The marrow can be studied to determine the cause of anemia, the presence of leukemia or other malignancy, or the presence of some storage diseases, in which abnormal metabolic products are stored in certain bone marrow cells.

    Bone marrow aspiration

    illustration

  • Hairy cell leukemia - microscopic view - illustration

    All the cells in this field are hairy cells. The cell membranes appear irregular and serrated. The cytoplasm stains light blue (black arrows). The nuclei tend to be irregular (red arrows).

    Hairy cell leukemia - microscopic view

    illustration

  • Enlarged spleen - illustration

    Because of its wide variety of functions, the spleen may be affected by many conditions involving the blood or lymph system, and by infection, malignancies, liver disease, and parasites.

    Enlarged spleen

    illustration


Aspirus St. Luke’s, 915 East First Street, Duluth, MN 55805 218.249.5555 | 800.321.3790

Review Date: 6/17/2024

Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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