Malignant hypertensionAccelerated hypertension; Arteriolar nephrosclerosis; Nephrosclerosis - arteriolar; Hypertension - malignant; High blood pressure - malignant
Malignant hypertension is very high blood pressure that comes on suddenly and quickly.
High blood pressure
Blood pressure is a measurement of the force exerted against the walls of your arteries as your heart pumps blood to your body. Hypertension is the ...Read Article Now Book Mark Article
The disorder affects a small number of people with high blood pressure, including children and adults. It is more common in younger adults, especially African American men.
It also occurs in people with:
- Collagen vascular disorders (such as systemic lupus erythematosus, systemic sclerosis, and periarteritis nodosa)
- Kidney problems
- Pregnancy-induced high blood pressure (toxemia)
You are at high risk for malignant hypertension if you smoke and if you have had:
- Kidney failure
- Renal hypertension caused by renal artery stenosis
Symptoms of malignant hypertension include:
- Blurred vision
- Change in mental status, such as anxiety, confusion, decreased alertness, decreased ability to concentrate, fatigue, restlessness, sleepiness, or stupor
Stress is a feeling of emotional or physical tension. It can come from any event or thought that makes you feel frustrated, angry, or nervous. Stres...Read Article Now Book Mark Article
Confusion is the inability to think as clearly or quickly as you normally do. You may feel disoriented and have difficulty paying attention, remembe...Read Article Now Book Mark Article
Decreased alertness is the most severe state of reduced awareness and is a serious condition. A coma is a state of decreased alertness from which a p...Read Article Now Book Mark Article
Fatigue is a feeling of weariness, tiredness, or lack of energy.Read Article Now Book Mark Article
Agitation is an unpleasant state of extreme arousal. An agitated person may feel stirred up, excited, tense, confused, or irritable.Read Article Now Book Mark Article
Drowsiness refers to feeling more sleepy than normal during the day. People who are drowsy may fall asleep in when they do not want to or at times w...Read Article Now Book Mark Article
- Chest pain (feeling of crushing or pressure)
- Nausea or vomiting
- Numbness of the arms, legs, face, or other areas
- Reduced urine output
- Shortness of breath
- Weakness of the arms, legs, face, or other areas
Exams and Tests
Malignant hypertension is a medical emergency.
A physical exam commonly shows:
- Extremely high blood pressure
- Swelling in the lower legs and feet
- Abnormal heart sounds and fluid in the lungs
- Changes in thinking, sensation, and reflexes
An eye exam will reveal changes that indicate high blood pressure, including:
- Bleeding of the retina (back part of the eye)
- Narrowing of the blood vessels in the retina
- Swelling of the optic nerve
- Other problems with the retina
Tests to determine damage to the kidneys may include:
A chest x-ray may show congestion in the lungs and an enlarged heart.
A chest x-ray is an x-ray of the chest, lungs, heart, large arteries, ribs, and diaphragm.Read Article Now Book Mark Article
This disease may also affect the results of these tests:
- Level of aldosterone (a hormone from the adrenal gland)
- Cardiac enzymes (markers of heart damage)
- CT scan of the brain
- Electrocardiogram (ECG)
- Renin level
- Urinary sediment
You will need to stay in the hospital until your severe high blood pressure is under control. You will receive medicines through a vein (IV) to reduce your blood pressure.
If there is fluid in your lungs, you will be given medicines called diuretics, which help the body remove fluid. Your doctor may give you medicines to protect your heart if you have signs of heart damage.
After your severe high blood pressure is under control, blood pressure medicines taken by mouth can control blood pressure. Your medicine may need to be changed sometimes. High blood pressure can be difficult to control.
Many body systems are at serious risk from the extreme rise in blood pressure. Organs including the brain, eyes, blood vessels, heart, and kidneys may be damaged.
The blood vessels of the kidney are very likely to be damaged by high blood pressure. Kidney failure may develop, which may be permanent. If this happens, you may need dialysis (machine that removes waste products from blood).
Dialysis treats end-stage kidney failure. It removes harmful substances from the blood when the kidneys cannot. This article focuses on peritoneal d...Read Article Now Book Mark Article
If treated right away, malignant hypertension can often be controlled without causing permanent problems. If it is not treated right away, it can be fatal.
These complications may occur:
- Brain damage (stroke, seizures)
- Heart damage, including: heart attack, angina (chest pain due to narrowed blood vessels or weakened heart muscle), heart rhythm disturbances
Most heart attacks are caused by a blood clot that blocks one of the coronary arteries. The coronary arteries bring blood and oxygen to the heart. ...Read Article Now Book Mark Article
- Kidney failure
- Permanent blindness
- Fluid in the lungs
When to Contact a Medical Professional
Go to the emergency room or call the local emergency number (such as 911) if you have symptoms of malignant hypertension. This is an emergency condition that can be life threatening.
Contact your health care provider if you know you have poorly controlled high blood pressure.
If you have high blood pressure, carefully monitor your blood pressure and take your medicines properly to help reduce your risk. Eat a healthy diet that is low in salt and fat.
Elliott WJ, Peixoto AJ, Bakris GL. Primary and secondary hypertension. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 46.
Greco BA, Umanath K. Renovascular hypertension and ischemic nephropathy. In: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Comprehensive Clinical Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 41.
Levy PD, Brody A. Hypertension. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 74.
Hypertensive kidney - illustration
The kidneys filter wastes and excrete fluid when the pressure of blood in the bloodstream forces blood through the internal structures of the kidney.
Review Date: 5/4/2021
Reviewed By: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.