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Fibromyalgia

Fibromyositis; FM; Fibrositis

Fibromyalgia is a condition in which a person has long-term pain that is spread throughout the body. The pain is most often accompanied by fatigue, sleep problems, difficulty concentrating, headaches, depression, and anxiety.

People with fibromyalgia may also have tenderness in the joints, muscles, tendons, and other soft tissues.

Causes

The cause of fibromyalgia is not known. Researchers think that it is due to a problem with how the central nervous system processes pain signals from nerves. Possible causes or triggers of fibromyalgia include:

  • Physical or emotional trauma.
  • Abnormal pain response: Areas in the brain that control pain may react differently in people with fibromyalgia.
  • Sleep disturbances.
  • Infection, such as a virus, although none has been identified.

Fibromyalgia is more common in females as compared to males.Women ages 20 to 50 are the most affected group of people.

The following conditions may be seen with fibromyalgia or have similar symptoms:

Symptoms

Widespread pain is the main symptom of fibromyalgia. Fibromyalgia appears to be on one end of a range of chronic widespread pain, which may be present in 10% to 15% of the general population. Fibromyalgia falls on the far end of that pain severity and chronicity scale and occurs in 1% to 5% of the general population.

The central feature of fibromyalgia is chronic pain in multiple sites. These sites are the head, each arm, the chest, the abdomen, each leg, the upper back and spine, and the lower back and spine (including the buttocks).

The pain may be mild to severe.

  • It may feel like a deep ache, or a stabbing, burning pain.
  • It may feel like it is coming from the joints, although the joints are not affected.

People with fibromyalgia tend to wake up with body pain and stiffness. For some people, pain improves during the day and gets worse at night. Some people have pain all day long.

Pain may get worse with:

  • Physical activity
  • Cold or damp weather
  • Anxiety and stress

Most people with fibromyalgia have at least one of these symptoms: fatigue, depressed mood, or sleep problems. Many people say that they cannot get to sleep or stay asleep, and they feel tired when they wake up.

Other symptoms in people with fibromyalgia may include:

  • Irritable bowel syndrome (IBS) or gastroesophageal reflux (GERD)
  • Memory and concentration problems
  • Numbness and tingling in hands and feet
  • Reduced ability to exercise
  • Tension or migraine headaches

Exams and Tests

To be diagnosed with fibromyalgia, you must have had at least 3 months of widespread pain with one or more of the following:

  • Ongoing problems with sleep
  • Fatigue
  • Thinking or memory problems

It is not necessary for the health care provider to find tender points during the exam to make a diagnosis.

Results from the physical exam, blood and urine tests, and imaging tests are normal. These tests may be done to check for other conditions with similar symptoms. Studies of breathing during sleeping may be done to find out if you have a condition called sleep apnea.

Fibromyalgia is common in every rheumatic disease and complicates diagnoses and therapy. These disorders include:

  • Rheumatoid arthritis
  • Osteoarthritis
  • Spondyloarthritis
  • Systemic lupus erythematosus

Treatment

The goals of treatment are to help relieve pain and other symptoms, to reduce disability, and to help the person cope with the symptoms.

The first type of treatment may involve:

  • Physical therapy
  • Exercise and fitness program
  • Stress-relief methods, including light massage and relaxation techniques

If these treatments do not work, your provider may also prescribe an antidepressant or muscle relaxant. Sometimes, combinations of medicines are helpful.

  • The goal of these medicines is to improve your sleep and help you better tolerate pain.
  • Medicine should be used along with exercise and behavior therapy.
  • Duloxetine (Cymbalta), pregabalin (Lyrica), and milnacipran (Savella) are medicines that are approved specifically for treating fibromyalgia.

Other medicines are also used to treat the condition, such as:

  • Anti-seizure drugs, such as gabapentin
  • Other antidepressants, such as amitriptyline
  • Muscle relaxants, such as cyclobenzaprine
  • Pain relievers, such as tramadol

If you have sleep apnea, a device called continuous positive airway pressure (CPAP) may be prescribed.

Cognitive-behavioral therapy is an important part of treatment. This therapy helps you learn how to:

  • Deal with negative thoughts
  • Keep a diary of pain and symptoms
  • Recognize what makes your symptoms worse
  • Seek out enjoyable activities
  • Set limits

Complementary and alternative treatments may also be helpful. These may include:

  • Tai chi
  • Yoga
  • Acupuncture

Support groups may also help.

Things you can do to help take care of yourself include:

  • Eat a well-balanced diet.
  • Avoid caffeine.
  • Practice a good sleep routine to improve quality of sleep.
  • Exercise regularly. Start with low-level exercise.

There is no evidence that opioids are effective in the treatment of fibromyalgia, and studies have suggested possible adverse effects.

Referral to a clinic with special expertise in diagnosing and treating fibromyalgia may be helpful.

Outlook (Prognosis)

Fibromyalgia is a long-term disorder. Sometimes, the symptoms improve. Other times, the pain may get worse and continue for months or years.

When to Contact a Medical Professional

Contact your provider if you have symptoms of fibromyalgia.

Prevention

There is no known prevention.

References

Arnold LM, Clauw DJ. Challenges of implementing fibromyalgia treatment guidelines in current clinical practice. Postgrad Med. 2017;129(7):709-714. PMID: 28562155 pubmed.ncbi.nlm.nih.gov/28562155/.

Borg-Stein J, Brassil ME, Borgstrom HE. Fibromyalgia. In: Frontera, WR, Silver JK, Rizzo TD, eds. Essentials of Physical Medicine and Rehabilitation. 4th ed. Philadelphia, PA: Elsevier; 2019:chap 102.

Crofford LJ. Fibromyalgia. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 55.

Gilron I, Chaparro LE, Tu D, et al. Combination of pregabalin with duloxetine for fibromyalgia: a randomized controlled trial. Pain. 2016;157(7):1532-1540. PMID: 26982602 pubmed.ncbi.nlm.nih.gov/26982602/.

Goldenberg DL. Diagnosing fibromyalgia as a disease, an illness, a state, or a trait? Arthritis Care Res (Hoboken). 2019;71(3):334-336. PMID: 30724034 pubmed.ncbi.nlm.nih.gov/30724034/.

Lauche R, Cramer H, Häuser W, Dobos G, Langhorst J. A systematic overview of reviews for complementary and alternative therapies in the treatment of the fibromyalgia syndrome. Evid-Based Complement Alternat Med. 2015; 2015:610615. doi:10.1155/2015/610615. PMID: 26246841 pubmed.ncbi.nlm.nih.gov/26246841/.

López-Solà M, Woo CW, Pujol J, et al. Towards a neurophysiological signature for fibromyalgia. Pain. 2017;158(1):34-47. PMID: 27583567 pubmed.ncbi.nlm.nih.gov/27583567/.

Minhas D, Clauw DJ. Fibromyalgia and related syndromes. In: Hochberg MC, Gravallese EM, Silman AJ, Hejjde D, Weinblatt ME, Weisman MH, eds. Rheumatology. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 88.

Wu YL, Chang LY, Lee HC, Fang SC, Tsai PS. Sleep disturbances in fibromyalgia: a meta-analysis of case-control studies. J Psychosom Res. 2017;96:89-97. PMID: 28545798 pubmed.ncbi.nlm.nih.gov/28545798/.

Text only

  • Fibromyalgia

    Animation

  •  

    Fibromyalgia - Animation

    Usually when you're in pain, you can quickly find the cause, like the muscle you strained while working out, or the cut you gave yourself while slicing carrots. Yet for people with fibromyalgia, the source of their pain is harder to pinpoint. Although they experience pain daily, it can take some time to find the cause, and to get the right treatment for it. Fibromyalgia is still somewhat of a mystery, because no one knows what causes it and it's often mistaken for conditions with similar symptoms, like Lyme disease or depression. Some people think fibromyalgia stems from physical or emotional trauma. Others believe it's caused by an abnormal response to pain. Whatever the cause, fibromyalgia leads to widespread areas of pain on both sides of the body, and both below and above the waist. The pain may feel like an ache, or a sharp stabbing feeling, and it doesn't go away. To be diagnosed with fibromyalgia, you need to have physical findings at at least 11 specific tender points, which can be in your arms, buttocks, chest, knees, lower back, neck, rib cage, shoulders, or thighs. Doctors may diagnose fibromyalgia without a tender point examination by using the widespread pain index (WPI), and the symptoms severity scale score (SS). If the symptoms have been present at a similar level for at least 3 months and there is no other disorder that would otherwise explain the pain. The pain may get worse when you exercise, go outside in cold weather, or are under a lot of stress. In addition to pain, you may have problems concentrating or fatigue, and waking up unrefreshed. And you may have any of a long list of other symptoms as well including in the GI tract, urinary system, nervous system, and skin. There's no cure for fibromyalgia, but there are treatments to control your symptoms. Your doctor will probably start you on an exercise regimen and have you work with a physical therapist. Some have found real help from acupuncture, learning Tai Chi, or taking yoga classes. You may also need to take medicine to help you sleep and relieve your pain. Medicines that are commonly prescribed for fibromyalgia include antidepressants, antiseizure medications, pain relievers, and sleep aids. Meanwhile, talking to a therapist can help you better manage and live with your pain, and deal with any negative thoughts you may have about your condition. Despite improvements in the way doctors diagnose and treat fibromyalgia, it's still a chronic condition. But by working with your doctor, you can manage the symptoms and learn to live with them, so that you can control your fibromyalgia, rather than the other way around.

  • Fibromyalgia - illustration

    Fibromyalgia is a common rheumatic syndrome indicating widespread pain in fibrous tissues, muscles, tendons, and other connective tissues, resulting in painful muscles without weakness. The cause of this disorder is unknown, although it is a chronic problem that can come and go for years. The nine paired red circles are recognized as common tender points associated with fibromyalgia.

    Fibromyalgia

    illustration

  • Fibromyalgia

    Animation

  •  

    Fibromyalgia - Animation

    Usually when you're in pain, you can quickly find the cause, like the muscle you strained while working out, or the cut you gave yourself while slicing carrots. Yet for people with fibromyalgia, the source of their pain is harder to pinpoint. Although they experience pain daily, it can take some time to find the cause, and to get the right treatment for it. Fibromyalgia is still somewhat of a mystery, because no one knows what causes it and it's often mistaken for conditions with similar symptoms, like Lyme disease or depression. Some people think fibromyalgia stems from physical or emotional trauma. Others believe it's caused by an abnormal response to pain. Whatever the cause, fibromyalgia leads to widespread areas of pain on both sides of the body, and both below and above the waist. The pain may feel like an ache, or a sharp stabbing feeling, and it doesn't go away. To be diagnosed with fibromyalgia, you need to have physical findings at at least 11 specific tender points, which can be in your arms, buttocks, chest, knees, lower back, neck, rib cage, shoulders, or thighs. Doctors may diagnose fibromyalgia without a tender point examination by using the widespread pain index (WPI), and the symptoms severity scale score (SS). If the symptoms have been present at a similar level for at least 3 months and there is no other disorder that would otherwise explain the pain. The pain may get worse when you exercise, go outside in cold weather, or are under a lot of stress. In addition to pain, you may have problems concentrating or fatigue, and waking up unrefreshed. And you may have any of a long list of other symptoms as well including in the GI tract, urinary system, nervous system, and skin. There's no cure for fibromyalgia, but there are treatments to control your symptoms. Your doctor will probably start you on an exercise regimen and have you work with a physical therapist. Some have found real help from acupuncture, learning Tai Chi, or taking yoga classes. You may also need to take medicine to help you sleep and relieve your pain. Medicines that are commonly prescribed for fibromyalgia include antidepressants, antiseizure medications, pain relievers, and sleep aids. Meanwhile, talking to a therapist can help you better manage and live with your pain, and deal with any negative thoughts you may have about your condition. Despite improvements in the way doctors diagnose and treat fibromyalgia, it's still a chronic condition. But by working with your doctor, you can manage the symptoms and learn to live with them, so that you can control your fibromyalgia, rather than the other way around.

  • Fibromyalgia - illustration

    Fibromyalgia is a common rheumatic syndrome indicating widespread pain in fibrous tissues, muscles, tendons, and other connective tissues, resulting in painful muscles without weakness. The cause of this disorder is unknown, although it is a chronic problem that can come and go for years. The nine paired red circles are recognized as common tender points associated with fibromyalgia.

    Fibromyalgia

    illustration

A Closer Look

 

 

Review Date: 1/25/2023

Reviewed By: Neil J. Gonter, MD, Assistant Professor of Medicine, Columbia University, NY and private practice specializing in Rheumatology at Rheumatology Associates of North Jersey, Teaneck, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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