Chylomicronemia syndrome

Chylomicronemia syndrome is a disorder in which the body does not break down fats (lipids) correctly. This causes fat particles called chylomicrons to build up in the blood. The disorder is passed down through families.

Causes

Chylomicronemia syndrome can occur due to a rare genetic disorder in which a protein (enzyme) called lipoprotein lipase (LpL) is broken or missing. It can also be caused by the absence of second factor called apo C-II, which activates LpL. LpL is normally found in fat and muscle. It helps break down certain lipids. When LpL is missing or broken, fat particles called chylomicrons build up in the blood. This buildup is called chylomicronemia.

Defects in apolipoprotein CII and apolipoprotein AV can cause the syndrome as well. It is more likely to occur when people who are predisposed to have high triglycerides (such as those who have familial combined hyperlipidemia or familial hypertriglyceridemia) develop diabetes, obesity or are exposed to certain medicines.

Familial combined hyperlipidemia

Familial combined hyperlipidemia is a disorder that is passed down through families. It causes high cholesterol and high blood triglycerides....

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Familial hypertriglyceridemia

Familial hypertriglyceridemia is a common disorder passed down through families. It causes a higher-than-normal level of triglycerides (a type of fa...

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Symptoms

Symptoms may start in infancy and include:

• Abdominal pain due to pancreatitis (inflammation of the pancreas).
• Symptoms of nerve damage, such as loss of feeling in the feet or legs, and memory loss.
• Yellow deposits of fatty material in the skin called xanthomas. These growths may appear on the back, buttocks, soles of the feet, or ankles, knees and elbows.

Exams and Tests

A physical exam and tests may show:

• Enlarged liver and spleen

  Enlarged liver

  Enlarged liver refers to swelling of the liver beyond its normal size. Hepatomegaly is another word to describe this problem. If both the liver and ...

  

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• Inflammation of the pancreas
• Fatty deposits under the skin
• Possibly fatty deposits in the retina of the eye

  Retina

  The retina is the light-sensitive layer of tissue at the back of the eyeball. Images that come through the eye's lens are focused on the retina. Th...

  

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A creamy layer will appear when blood spins in a laboratory machine. This layer is due to chylomicrons in the blood.

The triglyceride level is extremely high.

Triglyceride level

The triglyceride level is a blood test to measure the amount of triglycerides in your blood. Triglycerides are a type of fat. Your body makes some t...

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Treatment

A fat-free, alcohol-free diet is required. You may need to stop taking certain medicines that can make symptoms worse. Do not stop taking any medicine without first talking to your health care provider. Conditions such as dehydration and diabetes can make symptoms worse. If diagnosed, these conditions need to be treated and controlled.

Outlook (Prognosis)

A fat-free diet can reduce symptoms dramatically.

Possible Complications

When untreated, the excess chylomicrons may lead to bouts of pancreatitis. This condition can be very painful and even life threatening.

When to Contact a Medical Professional

Seek medical care right away if you have abdominal pain or other warning signs of pancreatitis.

Contact your provider if you have a personal or family history of high triglyceride levels.

Prevention

There is no way to prevent someone from inheriting this syndrome.

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