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Hereditary amyloidosis

Amyloidosis - hereditary; Familial amyloidosis

Hereditary amyloidosis is a condition in which abnormal protein deposits (called amyloid) form in almost every tissue in the body. Harmful deposits most often form in the heart, kidneys, and nervous system. These protein deposits damage the tissues and interfere with how organs work.

Causes

Hereditary amyloidosis is passed down from parents to their children (inherited). Genes may also play a role in primary amyloidosis.

Other types of amyloidosis are not inherited. They include:

  • Senile systemic: seen in people older than 70
  • Spontaneous: occurs without a known cause
  • Secondary: results from diseases such as cancer of certain blood cells (myeloma)

Specific conditions include:

Treatment

Treatment to improve the function of damaged organs will help relieve some symptoms of hereditary amyloidosis. A liver transplant may be helpful to reduce the creation of harmful amyloid proteins. Talk to your health care provider about treatments.

References

Gertz MA, Dispenzieri A. Amyloidosis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 174.

Lachmann HJ, Sharpley FA. Amyloidosis. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 123.

Text only

  • Amyloidosis of the fingers - illustration

    Amyloidosis refers to the extracellular deposition of a protein called amyloid. This protein deposition can affect multiple organs. The deposition of amyloid may be a by-product of normal aging, or may occur with several other conditions. In this picture, we see how amyloidosis can affect the skin as nodular deposits on the fingers.

    Amyloidosis of the fingers

    illustration

  • Amyloidosis of the fingers - illustration

    Amyloidosis refers to the extracellular deposition of a protein called amyloid. This protein deposition can affect multiple organs. The deposition of amyloid may be a by-product of normal aging, or may occur with several other conditions. In this picture, we see how amyloidosis can affect the skin as nodular deposits on the fingers.

    Amyloidosis of the fingers

    illustration


 

Review Date: 11/19/2023

Reviewed By: Jacob Berman, MD, MPH, Clinical Assistant Professor of Medicine, Division of General Internal Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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