Hepatitis C
Sustained virologic response - hepatitis C; SVR - hepatitis CHepatitis C is a viral disease that leads to swelling (inflammation) of the liver.
Other types of viral hepatitis include:
- Hepatitis A
Hepatitis A
Hepatitis A is inflammation (irritation and swelling) of the liver from the hepatitis A virus.
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Hepatitis B
Hepatitis B is irritation and swelling (inflammation) of the liver due to infection with the hepatitis B virus (HBV). Other types of viral hepatitis ...
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Hepatitis D
Hepatitis D is a viral infection caused by the hepatitis D virus (previously called the Delta agent). It causes symptoms only in people who also hav...
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Causes
Hepatitis C infection is caused by the hepatitis C virus (HCV).
You can catch hepatitis C if the blood of someone who has HCV enters your body. Exposure may occur:
- After a needle stick or sharps injury
After a needle stick or sharps injury
Being exposed to sharps (needles and other sharp medical instruments) or body fluids means that another person's blood or other body fluid touches yo...
Read Article Now Book Mark Article - If blood from someone who has HCV contacts a cut on your skin or contacts your eyes or mouth
- While injecting street drugs
People at risk for HCV are those who:
- Inject street drugs or share a needle with someone who has HCV
- Have been on long-term kidney dialysis
- Have regular contact with blood at work (such as a health care worker)
- Have unprotected sexual contact with a person who has HCV
- Were born to a mother who had HCV
- Received a tattoo or acupuncture with needles that were not disinfected properly after being used on another person (risk is very low with practitioners who have a tattoo license or permit or an acupuncture license)
- Received an organ transplant from a donor who has HCV
- Share personal items, such as toothbrushes and razors, with someone who has HCV (less common)
- Received a blood transfusion (rare in the United States since blood screening became available in 1992)
Blood transfusion
There are many reasons you may need a blood transfusion:After knee or hip replacement surgery, or other major surgery that results in blood lossAfter...
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Symptoms
Most people who are recently infected with HCV do not have symptoms. Some people have yellowing of the skin (jaundice). Chronic infection often causes no symptoms. But fatigue, depression and other problems can occur.
Persons who have long-term (chronic) infection often have no symptoms until their liver becomes scarred (cirrhosis). Most people with this condition are ill and have many health problems.
Cirrhosis
Cirrhosis is scarring of the liver and poor liver function. It is the last stage of chronic liver disease.
Read Article Now Book Mark ArticleThe following symptoms may occur with HCV infection:
- Pain in the right upper abdomen
- Abdominal swelling due to fluid (ascites)
Ascites
Ascites is the build-up of fluid in the space between the lining of the abdomen and abdominal organs.
Read Article Now Book Mark Article - Clay-colored or pale stools
- Dark urine
Dark urine
Blood in your urine is called hematuria. The amount may be very small and only detected with urine tests or under a microscope. In other cases, the...
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Fatigue
Fatigue is a feeling of weariness, tiredness, or lack of energy.
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Fever
Fever is the temporary increase in the body's temperature in response to a disease or illness. A child has a fever when the temperature is at or abov...
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Itching
Itching is a tingling or irritation of the skin that makes you want to scratch the area. Itching may occur all over the body or only in one location...
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- Loss of appetite
- Nausea and vomiting
Exams and Tests
Blood tests are done to check for HCV:
- Enzyme immunoassay (EIA) to detect HCV antibody
- Polymerase chain reaction (PCR) to detect the virus itself, to measure virus levels (viral load), and to identify the type of hepatitis C virus
All adults ages 18 to 79 should get a one-time test for HCV. This screening test checks for antibodies against HCV (anti-HCV). If the antibody test is positive, a PCR test is used to confirm HCV infection.
Further genetic testing is done to check for the type of HCV (genotype). There are six types of the virus (genotypes 1 through 6). Test results can help your health care provider choose treatment that is best for you.
The following tests are done to identify and monitor liver damage from HCV:
- Albumin level
- Liver function tests
- Prothrombin time
- Liver biopsy
- Transient elastography using ultrasound
- Magnetic resonance elastography (MRE)
Treatment
You should talk to your provider about your treatment options and when treatment should begin.
- The goal of treatment is to rid the body of the virus. This can prevent liver damage that may lead to liver failure or liver cancer.
Liver cancer
Hepatocellular carcinoma is cancer that starts in the liver.
Read Article Now Book Mark Article - Treatment is especially important for people who are showing signs of liver fibrosis or scarring.
Antiviral medicines are used to treat HCV. These medicines help fight HCV. Newer antiviral drugs:
- Provide an excellent cure rate
- Have fewer side effects and are easier to take than older medicines
- Are taken by mouth for 8 to 24 weeks
The choice of which medicine depends on the genotype of HCV you have.
A liver transplant may be recommended for people who develop cirrhosis and/or liver cancer. Your provider can tell you more about liver transplant.
Liver transplant
Liver transplant is surgery to replace a diseased liver with a healthy liver.
Read Article Now Book Mark ArticleIf you have HCV:
- Do not take over-the-counter medicines that you have not taken before without asking your provider. Also ask about vitamins and other supplements.
- Do not use alcohol or street drugs. Alcohol can speed up the damage to your liver. It can also reduce how well medicines work.
- If blood tests show that you do not have antibodies to hepatitis A and B, you should have the hepatitis A and hepatitis B vaccines. If you have not received a vaccine for hepatitis A or B or have not had these forms of hepatitis, you may need vaccination for them.
Support Groups
More information and support for people with HCV condition and their families can be found by joining a support group. Ask your provider about liver disease resources and support groups in your area.
Outlook (Prognosis)
Most people (75% to 85%) who are infected with the virus develop chronic HCV. This condition poses a risk for cirrhosis and liver cancer. The outlook for HCV depends in part on the genotype.
A good response to treatment occurs when the virus can no longer be detected in the blood 12 weeks or more after treatment. This is called "sustained virologic response" (SVR). Up to 90% of those treated for some genotypes have this type of response.
Some people do not respond to initial treatment. They may need to be re-treated with a different class of medicines.
Also, some people can become re-infected or infected with a different genotype strain.
When to Contact a Medical Professional
Contact your provider if:
- You develop symptoms of hepatitis
- You believe you have been exposed to HCV
Prevention
Steps that can be taken to help prevent the spread of HCV from one person to another include:
Prevent the spread of HCV
Hepatitis B and hepatitis C infections cause irritation (inflammation) and swelling of the liver. You should take steps to prevent catching or sprea...
Read Article Now Book Mark Article- Health care workers should follow precautions when handling blood.
- Do not share needles with anyone.
- Do not get tattoos or body piercings or receive acupuncture from someone who does not have a permit or license.
- Do not share personal items, such as razors and toothbrushes.
- Practice safe sex.
Safe sex
Safe sex means taking steps before and during sex that can prevent you from getting an infection, or from giving an infection to your partner. These...
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If you or your sexual partner is infected with HCV and you have been in a stable and monogamous (no other partners) relationship, the risk of giving the virus to, or getting the virus from, the other person is low.
HCV cannot be spread by casual contact, such as holding hands, kissing, coughing or sneezing, breastfeeding, sharing eating utensils or drinking glasses.
Currently there is no vaccine for HCV.
References
Bhattacharya D, Aronsohn A, Price J, Re III VL; the American Association for the Study of Liver Diseases–Infectious Diseases Society of America HCV Guidance Panel. Hepatitis C guidance 2023 update: American Association for the Study of Liver Diseases– Infectious Diseases Society of America recommendations for testing, managing, and treating hepatitis C virus infection. Clinical Infectious Diseases. 2023;ciad319. PMID: 37229695 pubmed.ncbi.nlm.nih.gov/37229695/.
Centers for Disease Control and Prevention. Hepatitis C. Hepatitis C basics. www.cdc.gov/hepatitis-c/about/. Updated May 30, 2024. Accessed June 17, 2024.
Holmes JA, Chung RT. Hepatitis C. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 80.
Naggie S, Wyles DL. Hepatitis C. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 154.
Pawlotsky J-M. Chronic viral and autoimmune hepatitis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 135.
Digestive system - illustration
The esophagus, stomach, large and small intestine, aided by the liver, gallbladder and pancreas convert the nutritive components of food into energy and break down the non-nutritive components into waste to be excreted.
Digestive system
illustration
Hepatitis C - illustration
Hepatitis C is a virus-caused liver inflammation which may cause jaundice, fever and cirrhosis. Persons who are most at risk for contracting and spreading hepatitis C are those who share needles for injecting drugs and health care workers or emergency workers who may be exposed to contaminated blood.
Hepatitis C
illustration
Digestive system - illustration
The esophagus, stomach, large and small intestine, aided by the liver, gallbladder and pancreas convert the nutritive components of food into energy and break down the non-nutritive components into waste to be excreted.
Digestive system
illustration
Hepatitis C - illustration
Hepatitis C is a virus-caused liver inflammation which may cause jaundice, fever and cirrhosis. Persons who are most at risk for contracting and spreading hepatitis C are those who share needles for injecting drugs and health care workers or emergency workers who may be exposed to contaminated blood.
Hepatitis C
illustration
Review Date: 5/2/2023
Reviewed By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Internal review and update on 02/10/2024 by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.