Vaccines - immunizations
Vaccines are used to boost your immune system and prevent the risk of infection and the severity of infections, including those that cause serious, life-threatening diseases.
Vaccines - Animation
Ouch! Vaccines help to give the body immunity from infections. Different vaccines work in different ways. Some vaccines inject fragments of a virus or bacteria called antigens into the body. Once in the blood, these antigens circulate among the blood cells, which include red blood cells and white blood cells. White blood cells, such as B and T cells, help fend off foreign invaders. When antigens invade tissue, they attract macrophages. These are scavenger cells that engulf the antigens. The macrophages then signal to T-cells that the antigens are invading. Killer T cells gather and attack the antigens. Then suppressor T cells stop the attack. After the vaccination, B-cells make defensive antibodies against the antigen. These antibodies help the cells remember this particular antigen, so that they can fight it off if the body is infected again.
Information
HOW VACCINES WORK
Vaccines "teach" your body how to defend itself when germs, such as viruses or bacteria, invade it:
- Vaccines expose you to a very small, very safe amount of viruses or bacteria that have been weakened or killed.
- Your immune system then learns to recognize and attack the infection if you are exposed to it later in life.
- As a result, you will not become ill, or you may have a milder infection. This is a natural way to deal with infectious diseases.
Five types of vaccines are currently available:
- Live virus vaccines use the weakened (attenuated) form of the virus. The measles, mumps, and rubella (MMR) vaccine and the varicella (chickenpox) vaccine are examples.
- Killed (inactivated) vaccines are made from a protein or other small pieces taken from a virus or bacteria. The whooping cough (pertussis) vaccine is an example.
- Toxoid vaccines contain a toxin or chemical made by the bacteria or virus. They make you immune to the harmful effects of the infection, instead of to the infection itself. Examples are the diphtheria and tetanus vaccines.
- Biosynthetic vaccines contain manmade substances that are very similar to pieces of the virus or bacteria. The Hepatitis B vaccine is an example.
- mRNA vaccines contain the genetic code of the virus the body can use to create antibodies to fight the virus. Some SARS-CoV2 vaccines use this technology.
WHY WE NEED VACCINES
For a few weeks after birth, babies have some protection from germs that cause diseases. This protection is passed from their mother through the placenta before birth. After a short period, this natural protection goes away.
Vaccines help protect against many diseases that used to be much more common. Examples include tetanus, diphtheria, mumps, measles, pertussis (whooping cough), meningitis, and polio. Many of these infections can cause serious or life-threatening illnesses and may lead to life-long health problems. Because of vaccines, many of these illnesses are now rare.
SAFETY OF VACCINES
Some people worry that vaccines are not safe and may be harmful, especially for children. They may ask their health care provider to wait or even choose not to have a vaccine. But the benefits of vaccines far outweigh their risks.
The American Academy of Pediatrics, the Centers for Disease Control and Prevention (CDC), and the National Academy of Medicine have all concluded that the benefits of vaccines outweigh their risks.
Vaccines, such as the measles, mumps, rubella, chickenpox, and nasal spray flu vaccines contain live, but weakened viruses:
- Unless a person's immune system is weakened, it is unlikely that a vaccine will give the person the illness caused by the infection. People with weakened immune systems should not receive these live virus vaccines.
- These live virus vaccines may be dangerous to the fetus of a pregnant woman. To avoid harm to the baby, pregnant women should not receive any of these vaccines. Your provider can tell you the right time to get these vaccines.
Thimerosal is a preservative that was found in most vaccines in the past. But now:
- There are infant and child flu vaccines that have no thimerosal.
- NO other vaccines commonly used for children or adults contain thimerosal.
- Research done over many years has NOT shown any link between thimerosal and autism or other medical problems.
Allergic reactions are rare and are usually to some part (component) of the vaccine.
VACCINE SCHEDULE
The recommended vaccination (immunization) schedule is updated at least every 12 months by the US Centers for Disease Control and Prevention (CDC). Talk to your provider about specific immunizations for you or your child. Current recommendations are available at the CDC website: www.cdc.gov/vaccines/imz-schedules/index.html.
TRAVELERS
The CDC website (wwwnc.cdc.gov/travel) has detailed information about immunizations and other precautions for travelers to other countries. Many immunizations should be received at least 1 month before travel.
Bring your immunization record with you when you travel to other countries. Some countries require this record.
COMMON IMMUNIZATIONS
- Chickenpox vaccine
Chickenpox vaccine
All content below is taken in its entirety from the CDC Chickenpox Vaccine Information Statement (VIS): www. cdc. gov/vaccines/hcp/vis/vis-statements...
Read Article Now Book Mark Article - DTaP vaccine (Diphtheria, Tetanus, Pertussis)
DTaP vaccine
All content below is taken in its entirety from the Centers for Disease Control and Prevention (CDC) DTaP vaccine information statement (VIS) -- www....
Read Article Now Book Mark Article - Hepatitis A vaccine
Hepatitis A vaccine
All content below is taken in its entirety from the CDC Hepatitis A Vaccine Information Statement (VIS): www. cdc. gov/vaccines/hcp/vis/vis-statement...
Read Article Now Book Mark Article - Hepatitis B vaccine
Hepatitis B vaccine
All content below is taken in its entirety from the CDC Hepatitis B Vaccine Information Statement (VIS): www. cdc. gov/vaccines/hcp/vis/vis-statement...
Read Article Now Book Mark Article - Hib vaccine
Hib vaccine
All content below is taken in its entirety from the CDC Hib (Haemophilus Influenzae Type b) Vaccine Information Statement (VIS): www. cdc. gov/vaccin...
Read Article Now Book Mark Article - HPV vaccine
HPV vaccine
The human papillomavirus (HPV) vaccine protects against infection by certain strains of HPV. HPV can cause cervical cancer and genital warts. HPV ha...
Read Article Now Book Mark Article - Influenza vaccine
Influenza vaccine
All content below is taken in its entirety from the CDC Inactivated Influenza Vaccine Information Statement (VIS) www. cdc. gov/vaccines/hcp/vis/vis-...
Read Article Now Book Mark Article - Meningococcal vaccine
Meningococcal vaccine
All content below is taken in its entirety from the CDC Meningococcal ACWY Vaccine Information Statement (VIS): www. cdc. gov/vaccines/hcp/vis/vis-st...
Read Article Now Book Mark Article - MMR vaccine
MMR vaccine
All content below is taken in its entirety from the CDC MMR (Measles, Mumps, & Rubella) Vaccine Information Statement (VIS): www. cdc. gov/vaccines/h...
Read Article Now Book Mark Article - Pneumococcal conjugate vaccine
Pneumococcal conjugate vaccine
Content below is taken in its entirety from the CDC Information Statement (VIS): www. cdc. gov/vaccines/hcp/vis/vis-statements/pcv. html
Read Article Now Book Mark Article - Pneumococcal polysaccharide vaccine
Pneumococcal polysaccharide vaccine
All content below is taken in its entirety from the CDC Pneumococcal Polysaccharide Vaccine Information Statement (VIS): www. cdc. gov/vaccines/hcp/v...
Read Article Now Book Mark Article - Polio vaccine
Polio vaccine
All content below is taken in its entirety from the CDC Polio Vaccine Information Statement (VIS): www. cdc. gov/vaccines/hcp/vis/vis-statements/ipv....
Read Article Now Book Mark Article - Rotavirus vaccine
Rotavirus vaccine
All content below is taken in its entirety from the CDC Rotavirus Vaccine Information Statement (VIS): www. cdc. gov/vaccines/hcp/vis/vis-statements/...
Read Article Now Book Mark Article - Shingles vaccine
Shingles vaccine
All content below is taken in its entirety from the CDC Recombinant Shingles Vaccine Information Statement (VIS): www. cdc. gov/vaccines/hcp/vis/vis-...
Read Article Now Book Mark Article - Tdap vaccine
Tdap vaccine
All content below is taken in its entirety from the Centers for Disease Control (CDC) Tdap Vaccine Information Statement (VIS): www. cdc. gov/vaccine...
Read Article Now Book Mark Article - Tetanus vaccine
- COVID-19 vaccine
COVID-19 vaccine
COVID-19 vaccines are used to prepare the body's immune system to protect against COVID-19. Everyone ages 6 months and older should get a 2024-2025 C...
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Reviewed By
Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Internal review and update on 07/12/2023 by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. Editorial update 01/29/2024.
Bernstein HH, Kilinsky A, Orenstein WA. Immunization practices. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 197.
Centers for Disease Control and Prevention website. Adult immunization schedule by age: recommendations for ages 19 years or older, United States, 2023. www.cdc.gov/vaccines/imz-schedules/index.html. Updated November 16, 2023. Accessed January 29, 2024.
Centers for Disease Control and Prevention website. Child and adolescent immunization schedule by age: recommendations for ages 18 years or younger, United States, 2023. www.cdc.gov/vaccines/imz-schedules/index.html. Updated February 10, 2023. Accessed September 5, 2024
Centers for Disease Control and Prevention website. Thimerosal FAQs. www.cdc.gov/vaccine-safety/about/thimerosal.html. Updated July 31, 2024. Accessed August 5, 2024.
Kroger AT, Pickering LK, Mawle A, Hinman AR, Orenstein WA. Immunization. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 316.
Kroger AT, Orenstein WA. Immunization. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 15.