Bupivacaine/meloxicam (By injection)Bupivacaine (bue-PIV-a-kane), Meloxicam (mel-OX-i-kam)Numbs an area of your body and relieves pain after soft tissue surgery (including surgery in the breast, groin, or stomach) or muscle or bone surgery (including surgery in the foot, knee, shoulder, or spine).Brand Name(s): There may be other brand names for this medicine.When This Medicine Should Not Be Used: This medicine is not right for everyone. You should not receive it if you had an allergic reaction to bupivacaine, meloxicam, or similar medicines (including aspirin). This medicine should not be used to ease pain during childbirth or a heart surgery, called coronary artery bypass graft (CABG).How to Use This Medicine: InjectableA nurse or other health provider will give you this medicine. It is usually given in the area where you had a surgery.Drugs and Foods to Avoid: Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.Do not use aspirin or any other NSAID medicine (including diflunisal, salsalate) unless your doctor says it is okay. Some medicines can affect how bupivacaine and meloxicam work. Tell your doctor if you are taking any of the following: Acetaminophen, chloroquine, cyclosporine, digoxin, lithium, methotrexate, metoclopramide, pemetrexed, primaquine, quinine, sulfasalazine Blood pressure medicine (including ACE inhibitors, ARBs, beta blockers) Blood thinner (including warfarin) Cancer medicine (including cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase) Diuretics (water pill) Medicine to treat depression (including SNRIs, SSRIs) Medicine to treat an infection (including dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides) Medicine to treat seizures (including phenobarbital, phenytoin, sodium valproate) Nitrate or nitrite medicine (including nitric oxide, nitroglycerin, nitroprusside, nitrous oxide) Other local anesthetics Steroid medicineWarnings While Using This Medicine: Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy unless your doctor tells you it is okay. Tell your doctor if you have kidney disease, liver disease, heart or blood vessel disease (including heart failure), heart rhythm problems (including heart block), high or low blood pressure, lung or breathing problems (including asthma), bleeding problems, blood or blood clotting problems (including methemoglobinemia), G6PD, or a history of heart attack, stroke, or stomach problems (including ulcers). Tell your doctor if you smoke or drink alcohol regularly. This medicine may cause the following problems:Increased risk of blood clots, heart attack, stroke, or heart failure Bleeding problems, including stomach or bowel bleeding or ulcer Liver problems High blood pressure Kidney problems Chondrolysis (a bone or joint problem) Methemoglobinemia (blood disorder) Serious skin reactions, including Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS) This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. This medicine may cause a delay in ovulation in females and may decrease sperm count in males, which can affect the ability to have children. If you plan to have children, talk with your doctor before using this medicine. This medicine should cause numbness only to the area where it is injected. It is not meant to cause you to fall asleep or become unconscious. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Possible Side Effects While Using This Medicine: Call your doctor right away if you notice any of these side effects:Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing Anxiety, depression, restlessness, dizziness, drowsiness, ringing in your ears, blurred vision, muscle twitching Blistering, peeling, red skin rash Change in how much or how often you urinate, difficult or painful urination Chest pain, trouble breathing, fast, pounding, slow, or uneven heartbeat Confusion, numbness or tingling in your hands, feet, or lips Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes Fever, chills, cough, sore throat, body aches Lightheadedness, dizziness, or fainting Metallic taste in your mouth or other changes in taste Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking Pale, gray, or blue lips, nails, or skin, dark urine, headache, tiredness Rapid weight gain, swelling in your hands, ankles, or feet Severe stomach pain, vomiting blood or material that looks like coffee grounds, bloody or black, tarry stools Shoulder discomfort, pain, or stiffness Unusual bleeding, bruising, or weaknessIf you notice these less serious side effects, talk with your doctor:Constipation Pain, redness, or swelling where the needle was placed Unusual skin odor, slow wound healingIf you notice other side effects that you think are caused by this medicine, tell your doctorCall your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 Last Updated: 9/6/2024