Delta-ALA is a protein (amino acid) produced by the liver. A test can be done to measure the amount of this substance in the urine.

Delta-aminolevulinic acid

Your health care provider will ask you to collect your urine at home over 24 hours. This is called a 24-hour urine sample. Your provider will tell you how to do this. Follow instructions exactly.

Your provider may tell you to temporarily stop taking any medicines that can affect test results. Be sure to tell your provider about all the medicines you take. These include:

• Penicillin (an antibiotic)
• Barbiturates (medicines to treat anxiety)
• Birth control pills
• Griseofulvin (medicine to treat fungal infections)

The test involves only normal urination. There is no discomfort.

This test looks for an increased level of delta-ALA. It may be used to help diagnose a blood disorder called porphyria.

Normal value range for adults is 1.0 to 7.0 mg (7.6 to 53.3 mol/L) over 24 hours.

Normal value ranges may vary slightly from one lab to another. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.

An increased level of urinary delta-ALA may indicate:

• Lead poisoning
• Porphyria (several types)

 A decreased level may occur with chronic (long-term) liver disease.

There are no risks with this test.

Fuller SJ, Wiley JS. Heme biosynthesis and its disorders: porphyrias and sideroblastic anemias. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 39.

Squires JE, Balistreri WF. Other inherited metabolic disorders of the liver. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 77.