BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuCSF myelin basic proteinCSF myelin basic protein is a test to measure the level of myelin basic protein (MBP) in the cerebrospinal fluid (CSF). MyelinMyelin is an insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty ...ImageRead Article Now Book Mark Article CSF is a clear liquid that surrounds the brain and spinal cord.MBP is found in the material that covers many of your nerves. How the Test is Performed A sample of spinal fluid is needed. This is done using a lumbar puncture.Lumbar punctureCerebrospinal fluid (CSF) collection is a test to look at the fluid that surrounds the brain and spinal cord. CSF acts as a cushion, protecting the b...ImageRead Article Now Book Mark Article Why the Test is Performed This test is done to see if myelin is breaking down. Multiple sclerosis is the most common cause for this, but other causes may include:Multiple sclerosisMultiple sclerosis (MS) is an autoimmune disease that affects the brain and spinal cord (central nervous system).ImageRead Article Now Book Mark Article Bleeding of the central nervous system Central nervous system trauma Central nervous system traumaSpinal cord trauma is damage to the spinal cord. It may result from direct injury to the cord itself or indirectly from disease of the nearby bones,...ImageRead Article Now Book Mark Article Certain brain diseases (encephalopathies) Infection of the central nervous system Stroke StrokeA stroke occurs when blood flow to a part of the brain stops. A stroke is sometimes called a "brain attack. " If blood flow is cut off for longer th...ImageRead Article Now Book Mark Article Traumatic brain injury Normal Results In general, there should be less than 4 ng/mL of myelin basic protein in the CSF.Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.The example above shows the common measurement result for this test. Some laboratories use different measurements or may test different specimens. What Abnormal Results Mean Myelin basic protein levels from 4 to 8 ng/mL may be a sign of a long-term (chronic) breakdown of myelin. It may also indicate recovery from an acute episode of myelin breakdown.ChronicChronic refers to something that continues over an extended period of time. A chronic condition is usually long-lasting and does not easily or quick...ImageRead Article Now Book Mark Article AcuteAcute means sudden. Acute symptoms appear, change, or worsen rapidly. It is the opposite of chronic.ImageRead Article Now Book Mark Article If the myelin basic protein level is 9 ng/mL or greater, myelin is actively breaking down.Open ReferencesReferencesEuerle BD. Spinal puncture and cerebrospinal fluid examination. In: Roberts JR, Custalow CB, Thomsen TW, eds. Roberts and Hedges' Clinical Procedures in Emergency Medicine and Acute Care. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 60.Fabian MT, Krieger SC, Lublin FD. Multiple sclerosis and other inflammatory demyelinating diseases of the central nervous system. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022: chap 80.Karcher DS, McPherson RA. Cerebrospinal, synovial, serous body fluids, and alternative specimens. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 30.AllVideoImagesTogLumbar puncture (spinal tap) - illustration A lumbar puncture, or spinal tap, is a procedure to collect cerebrospinal fluid to check for the presence of disease or injury. A spinal needle is inserted, usually between the third and fourth lumbar vertebrae in the lower spine. Once the needle is properly positioned in the subarachnoid space (the space between the spinal cord and its covering, the meninges), pressures can be measured and fluid can be collected for testing.Lumbar puncture (spinal tap)illustrationLumbar puncture (spinal tap) - illustration A lumbar puncture, or spinal tap, is a procedure to collect cerebrospinal fluid to check for the presence of disease or injury. A spinal needle is inserted, usually between the third and fourth lumbar vertebrae in the lower spine. Once the needle is properly positioned in the subarachnoid space (the space between the spinal cord and its covering, the meninges), pressures can be measured and fluid can be collected for testing.Lumbar puncture (spinal tap)illustration Tests for CSF myelin basic protein CSF myelin basic proteinCSF analysisRelated Information Myelin(Special Topic)Multiple sclerosis(Condition)Stroke(Condition)Spinal cord trauma(Condition)Chronic(Special Topic)Acute(Special Topic)Multiple sclerosis - InDepth(In-Depth)Stroke - InDepth(In-Depth) Review Date: 4/29/2023 Reviewed By: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School of Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. 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CSF myelin basic proteinCSF myelin basic protein is a test to measure the level of myelin basic protein (MBP) in the cerebrospinal fluid (CSF). MyelinMyelin is an insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. It is made up of protein and fatty ...ImageRead Article Now Book Mark Article CSF is a clear liquid that surrounds the brain and spinal cord.MBP is found in the material that covers many of your nerves. How the Test is Performed A sample of spinal fluid is needed. This is done using a lumbar puncture.Lumbar punctureCerebrospinal fluid (CSF) collection is a test to look at the fluid that surrounds the brain and spinal cord. CSF acts as a cushion, protecting the b...ImageRead Article Now Book Mark Article Why the Test is Performed This test is done to see if myelin is breaking down. Multiple sclerosis is the most common cause for this, but other causes may include:Multiple sclerosisMultiple sclerosis (MS) is an autoimmune disease that affects the brain and spinal cord (central nervous system).ImageRead Article Now Book Mark Article Bleeding of the central nervous system Central nervous system trauma Central nervous system traumaSpinal cord trauma is damage to the spinal cord. It may result from direct injury to the cord itself or indirectly from disease of the nearby bones,...ImageRead Article Now Book Mark Article Certain brain diseases (encephalopathies) Infection of the central nervous system Stroke StrokeA stroke occurs when blood flow to a part of the brain stops. A stroke is sometimes called a "brain attack. " If blood flow is cut off for longer th...ImageRead Article Now Book Mark Article Traumatic brain injury Normal Results In general, there should be less than 4 ng/mL of myelin basic protein in the CSF.Normal value ranges may vary slightly among different laboratories. Talk to your health care provider about the meaning of your specific test results.The example above shows the common measurement result for this test. Some laboratories use different measurements or may test different specimens. What Abnormal Results Mean Myelin basic protein levels from 4 to 8 ng/mL may be a sign of a long-term (chronic) breakdown of myelin. It may also indicate recovery from an acute episode of myelin breakdown.ChronicChronic refers to something that continues over an extended period of time. A chronic condition is usually long-lasting and does not easily or quick...ImageRead Article Now Book Mark Article AcuteAcute means sudden. Acute symptoms appear, change, or worsen rapidly. It is the opposite of chronic.ImageRead Article Now Book Mark Article If the myelin basic protein level is 9 ng/mL or greater, myelin is actively breaking down.Open ReferencesReferencesEuerle BD. Spinal puncture and cerebrospinal fluid examination. In: Roberts JR, Custalow CB, Thomsen TW, eds. Roberts and Hedges' Clinical Procedures in Emergency Medicine and Acute Care. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 60.Fabian MT, Krieger SC, Lublin FD. Multiple sclerosis and other inflammatory demyelinating diseases of the central nervous system. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022: chap 80.Karcher DS, McPherson RA. Cerebrospinal, synovial, serous body fluids, and alternative specimens. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 30.