BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuAmitriptyline and perphenazine overdoseTriptazine overdoseAmitriptyline and perphenazine is a combination medicine. It is sometimes prescribed for people with depression, agitation, or anxiety.Amitriptyline and perphenazine overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose.This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with has an overdose, call your local emergency number (such as 911), or your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.OverdoseAn overdose is when you take more than the recommended amount of something, often a medicine or drug. An overdose may result in serious, harmful sym...Read Article Now Book Mark Article Poisonous Ingredient Amitriptyline and perphenazine can be very harmful in large amounts. Where Found Medicines with this brand name contain amitriptyline and perphenazine:TriptazineOther medicines may also contain amitriptyline and perphenazine. Symptoms Below are symptoms of an amitriptyline and perphenazine overdose in different parts of the body. These symptoms may occur more often or be more severe in people who also take certain other medicines that affect serotonin, a chemical in the brain.AIRWAYS AND LUNGSSlowed, labored breathing Slowed, labored breathingBreathing difficulty may involve:Difficult breathing Uncomfortable breathingFeeling like you are not getting enough airRead Article Now Book Mark Article No breathingBLADDER AND KIDNEYSHard to start urinating, and urine stream may be weak Hard to start urinatingDifficulty starting or maintaining a urine stream is called urinary hesitancy.Read Article Now Book Mark Article Inability to completely empty the bladderEYES, EARS, NOSE, THROAT, AND MOUTHBlurred vision Blurred visionThere are many types of eye problems and vision disturbances, such as: Halos Blurred vision (the loss of sharpness of vision and the inability to see...Read Article Now Book Mark Article Dry mouth Dry mouthDry mouth occurs when you don't make enough saliva. This causes your mouth to feel dry and uncomfortable. Dry mouth that is ongoing may be a sign o...Read Article Now Book Mark Article Enlarged pupils Eye pain in people at risk for a type of glaucoma GlaucomaGlaucoma is a group of eye conditions that can damage the optic nerve. This nerve sends the images you see to your brain. Most often, optic nerve da...Read Article Now Book Mark Article Nasal congestion Nasal congestionA stuffy or congested nose occurs when the tissues lining it become swollen. The swelling is due to inflamed blood vessels. The problem may also in...Read Article Now Book Mark Article Unpleasant taste in mouthHEART AND BLOODIrregular heartbeat Irregular heartbeatPalpitations are feelings or sensations that your heart is pounding or racing. They can be felt in your chest, throat, or neck. You may:Have an unpl...Read Article Now Book Mark Article Low blood pressure (severe) Rapid heartbeat Rapid heartbeatPalpitations are feelings or sensations that your heart is pounding or racing. They can be felt in your chest, throat, or neck. You may:Have an unpl...Read Article Now Book Mark Article ShockShockShock is a life-threatening condition that occurs when the body is not getting enough blood flow. Lack of blood flow means the cells and organs do n...Read Article Now Book Mark Article MUSCLES AND JOINTS Muscles are rigid Muscle cramps, spasms, or stiffness of the limbs Muscle crampsMuscle cramps are when a muscle gets tight (contracts) without you trying to tighten it, and it does not relax. Cramps may involve all or part of on...Read Article Now Book Mark Article Stiff muscles in neck, face, or back NERVOUS SYSTEMAgitation AgitationAgitation is an unpleasant state of extreme arousal. An agitated person may feel stirred up, excited, tense, confused, or irritable.Read Article Now Book Mark Article Coma (decreased level of consciousness and lack of responsiveness) ComaDecreased alertness is a state of reduced awareness and is often a serious condition. A coma is the most severe state of decreased alertness from whi...Read Article Now Book Mark Article Seizures SeizuresA seizure is the physical changes in behavior that occurs during an episode of specific types of abnormal electrical activity in the brain. The term ...Read Article Now Book Mark Article Delirium DeliriumDelirium is sudden severe confusion due to rapid changes in brain function that can occur with physical or mental illness.Read Article Now Book Mark Article Disorientation Drowsiness DrowsinessDrowsiness refers to feeling more sleepy than normal during the day. People who are drowsy may fall asleep when they do not want to or at times whic...Read Article Now Book Mark Article Lower than normal body temperature Lower than normal body temperatureHypothermia is dangerously low body temperature, below 95°F (35°C).Read Article Now Book Mark Article Restlessness RestlessnessAgitation is an unpleasant state of extreme arousal. An agitated person may feel stirred up, excited, tense, confused, or irritable.Read Article Now Book Mark Article Uncoordinated movement Uncoordinated movementUncoordinated movement is due to a muscle control problem that causes an inability to coordinate movements. It leads to a jerky, unsteady, to-and-fr...Read Article Now Book Mark Article Tremor TremorA tremor is a type of shaking movement. A tremor is most often noticed in the hands and arms. It may affect any body part, including the head, tong...Read Article Now Book Mark Article WeaknessREPRODUCTIVE SYSTEMChange in menstrual patternsSKINItchy skin ItchyItching is a tingling or irritation of the skin that makes you want to scratch the area. Itching may occur all over the body or only in one location...Read Article Now Book Mark Article RashRashRashes involve changes in the color, feeling or texture of your skin.Read Article Now Book Mark Article STOMACH AND INTESTINESConstipation ConstipationConstipation in infants and children means they have hard stools or have problems passing stools. A child may have pain while passing stools or may ...Read Article Now Book Mark Article Loss of appetite Loss of appetiteA decreased appetite is when your desire to eat is reduced. The medical term for a loss of appetite is anorexia.Read Article Now Book Mark Article Nausea and vomitingNausea and vomitingNausea is feeling an urge to vomit. It is often called "being sick to your stomach. "Vomiting or throwing-up forces the contents of the stomach up t...Read Article Now Book Mark Article Before Calling Emergency Have this information ready: Person's age, weight, and condition Name of the product (ingredients and strength, if known) Time it was swallowed Amount swallowed If the medicine was prescribed for the person Poison Control Your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.Poison control centerFor a POISON EMERGENCY call:1-800-222-1222ANYWHERE IN THE UNITED STATESThis national hotline number will let you talk to experts in poisoning. This ...Read Article Now Book Mark Article This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week. What to Expect at the Emergency Room Take the container to the hospital with you, if possible.The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure.Vital signsVital signs reflect essential body functions, including your heartbeat, breathing rate, temperature, and blood pressure. Your health care provider m...Read Article Now Book Mark Article Tests that may be done include:Blood and urine tests Chest x-ray Chest x-rayA chest x-ray is an x-ray of the chest, lungs, heart, large arteries, ribs, and diaphragm.Read Article Now Book Mark Article CT scan CT scanA computed tomography (CT) scan is an imaging method that uses x-rays to create pictures of cross-sections of the body. Related tests include:Abdomin...Read Article Now Book Mark Article Electrocardiogram (ECG)ElectrocardiogramAn electrocardiogram (ECG) is a test that records the electrical activity of the heart.Read Article Now Book Mark Article Treatment may include:Fluids through a vein (by IV) Medicine called an antidote to reverse the effects of the poison and treat symptoms, such as sodium bicarbonate or lidocaine Activated charcoal Laxative Breathing support, including a tube through the mouth into the lungs and connected to a breathing machine (ventilator) Outlook (Prognosis) An overdose of amitriptyline and perphenazine can be very serious.People who swallow too much of this medicine are almost always admitted to the hospital.How well someone does depends on how much of the medicine was swallowed and how quickly treatment is given. The faster a person gets medical help, the better the chance of recovery. Complications such as heart rhythm disturbances, pneumonia, muscle damage from lying on a hard surface for a long period of time, or brain damage from lack of oxygen may result in permanent disability. Death can occur.Open ReferencesReferencesAronson JK. Tricyclic antidepressants. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:146-169.Huffman JC, Beach SR, Stern TA. Side effects of psychotropic medications. In: Stern TA, Fava M, Wilens TE, Rosenbaum JF, eds. Massachusetts General Hospital Psychopharmacology and Neurotherapeutics. Philadelphia, PA: Elsevier; 2016:chap 12.Levine MD, Ruha A-M. Antidepressants. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 141.AllVideoImagesTogRelated Information Review Date: 11/2/2023 Reviewed By: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited. © 1997- All rights reserved. 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Amitriptyline and perphenazine overdoseTriptazine overdoseAmitriptyline and perphenazine is a combination medicine. It is sometimes prescribed for people with depression, agitation, or anxiety.Amitriptyline and perphenazine overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose.This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with has an overdose, call your local emergency number (such as 911), or your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.OverdoseAn overdose is when you take more than the recommended amount of something, often a medicine or drug. An overdose may result in serious, harmful sym...Read Article Now Book Mark Article Poisonous Ingredient Amitriptyline and perphenazine can be very harmful in large amounts. Where Found Medicines with this brand name contain amitriptyline and perphenazine:TriptazineOther medicines may also contain amitriptyline and perphenazine. Symptoms Below are symptoms of an amitriptyline and perphenazine overdose in different parts of the body. These symptoms may occur more often or be more severe in people who also take certain other medicines that affect serotonin, a chemical in the brain.AIRWAYS AND LUNGSSlowed, labored breathing Slowed, labored breathingBreathing difficulty may involve:Difficult breathing Uncomfortable breathingFeeling like you are not getting enough airRead Article Now Book Mark Article No breathingBLADDER AND KIDNEYSHard to start urinating, and urine stream may be weak Hard to start urinatingDifficulty starting or maintaining a urine stream is called urinary hesitancy.Read Article Now Book Mark Article Inability to completely empty the bladderEYES, EARS, NOSE, THROAT, AND MOUTHBlurred vision Blurred visionThere are many types of eye problems and vision disturbances, such as: Halos Blurred vision (the loss of sharpness of vision and the inability to see...Read Article Now Book Mark Article Dry mouth Dry mouthDry mouth occurs when you don't make enough saliva. This causes your mouth to feel dry and uncomfortable. Dry mouth that is ongoing may be a sign o...Read Article Now Book Mark Article Enlarged pupils Eye pain in people at risk for a type of glaucoma GlaucomaGlaucoma is a group of eye conditions that can damage the optic nerve. This nerve sends the images you see to your brain. Most often, optic nerve da...Read Article Now Book Mark Article Nasal congestion Nasal congestionA stuffy or congested nose occurs when the tissues lining it become swollen. The swelling is due to inflamed blood vessels. The problem may also in...Read Article Now Book Mark Article Unpleasant taste in mouthHEART AND BLOODIrregular heartbeat Irregular heartbeatPalpitations are feelings or sensations that your heart is pounding or racing. They can be felt in your chest, throat, or neck. You may:Have an unpl...Read Article Now Book Mark Article Low blood pressure (severe) Rapid heartbeat Rapid heartbeatPalpitations are feelings or sensations that your heart is pounding or racing. They can be felt in your chest, throat, or neck. You may:Have an unpl...Read Article Now Book Mark Article ShockShockShock is a life-threatening condition that occurs when the body is not getting enough blood flow. Lack of blood flow means the cells and organs do n...Read Article Now Book Mark Article MUSCLES AND JOINTS Muscles are rigid Muscle cramps, spasms, or stiffness of the limbs Muscle crampsMuscle cramps are when a muscle gets tight (contracts) without you trying to tighten it, and it does not relax. Cramps may involve all or part of on...Read Article Now Book Mark Article Stiff muscles in neck, face, or back NERVOUS SYSTEMAgitation AgitationAgitation is an unpleasant state of extreme arousal. An agitated person may feel stirred up, excited, tense, confused, or irritable.Read Article Now Book Mark Article Coma (decreased level of consciousness and lack of responsiveness) ComaDecreased alertness is a state of reduced awareness and is often a serious condition. A coma is the most severe state of decreased alertness from whi...Read Article Now Book Mark Article Seizures SeizuresA seizure is the physical changes in behavior that occurs during an episode of specific types of abnormal electrical activity in the brain. The term ...Read Article Now Book Mark Article Delirium DeliriumDelirium is sudden severe confusion due to rapid changes in brain function that can occur with physical or mental illness.Read Article Now Book Mark Article Disorientation Drowsiness DrowsinessDrowsiness refers to feeling more sleepy than normal during the day. People who are drowsy may fall asleep when they do not want to or at times whic...Read Article Now Book Mark Article Lower than normal body temperature Lower than normal body temperatureHypothermia is dangerously low body temperature, below 95°F (35°C).Read Article Now Book Mark Article Restlessness RestlessnessAgitation is an unpleasant state of extreme arousal. An agitated person may feel stirred up, excited, tense, confused, or irritable.Read Article Now Book Mark Article Uncoordinated movement Uncoordinated movementUncoordinated movement is due to a muscle control problem that causes an inability to coordinate movements. It leads to a jerky, unsteady, to-and-fr...Read Article Now Book Mark Article Tremor TremorA tremor is a type of shaking movement. A tremor is most often noticed in the hands and arms. It may affect any body part, including the head, tong...Read Article Now Book Mark Article WeaknessREPRODUCTIVE SYSTEMChange in menstrual patternsSKINItchy skin ItchyItching is a tingling or irritation of the skin that makes you want to scratch the area. Itching may occur all over the body or only in one location...Read Article Now Book Mark Article RashRashRashes involve changes in the color, feeling or texture of your skin.Read Article Now Book Mark Article STOMACH AND INTESTINESConstipation ConstipationConstipation in infants and children means they have hard stools or have problems passing stools. A child may have pain while passing stools or may ...Read Article Now Book Mark Article Loss of appetite Loss of appetiteA decreased appetite is when your desire to eat is reduced. The medical term for a loss of appetite is anorexia.Read Article Now Book Mark Article Nausea and vomitingNausea and vomitingNausea is feeling an urge to vomit. It is often called "being sick to your stomach. "Vomiting or throwing-up forces the contents of the stomach up t...Read Article Now Book Mark Article Before Calling Emergency Have this information ready: Person's age, weight, and condition Name of the product (ingredients and strength, if known) Time it was swallowed Amount swallowed If the medicine was prescribed for the person Poison Control Your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.Poison control centerFor a POISON EMERGENCY call:1-800-222-1222ANYWHERE IN THE UNITED STATESThis national hotline number will let you talk to experts in poisoning. This ...Read Article Now Book Mark Article This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week. What to Expect at the Emergency Room Take the container to the hospital with you, if possible.The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure.Vital signsVital signs reflect essential body functions, including your heartbeat, breathing rate, temperature, and blood pressure. Your health care provider m...Read Article Now Book Mark Article Tests that may be done include:Blood and urine tests Chest x-ray Chest x-rayA chest x-ray is an x-ray of the chest, lungs, heart, large arteries, ribs, and diaphragm.Read Article Now Book Mark Article CT scan CT scanA computed tomography (CT) scan is an imaging method that uses x-rays to create pictures of cross-sections of the body. Related tests include:Abdomin...Read Article Now Book Mark Article Electrocardiogram (ECG)ElectrocardiogramAn electrocardiogram (ECG) is a test that records the electrical activity of the heart.Read Article Now Book Mark Article Treatment may include:Fluids through a vein (by IV) Medicine called an antidote to reverse the effects of the poison and treat symptoms, such as sodium bicarbonate or lidocaine Activated charcoal Laxative Breathing support, including a tube through the mouth into the lungs and connected to a breathing machine (ventilator) Outlook (Prognosis) An overdose of amitriptyline and perphenazine can be very serious.People who swallow too much of this medicine are almost always admitted to the hospital.How well someone does depends on how much of the medicine was swallowed and how quickly treatment is given. The faster a person gets medical help, the better the chance of recovery. Complications such as heart rhythm disturbances, pneumonia, muscle damage from lying on a hard surface for a long period of time, or brain damage from lack of oxygen may result in permanent disability. Death can occur.Open ReferencesReferencesAronson JK. Tricyclic antidepressants. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:146-169.Huffman JC, Beach SR, Stern TA. Side effects of psychotropic medications. In: Stern TA, Fava M, Wilens TE, Rosenbaum JF, eds. Massachusetts General Hospital Psychopharmacology and Neurotherapeutics. Philadelphia, PA: Elsevier; 2016:chap 12.Levine MD, Ruha A-M. Antidepressants. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 141.