BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuProgeriaHutchinson-Gilford progeria syndrome; HGPSProgeria is a rare genetic condition that produces rapid aging in children. Causes Progeria is a rare condition. It is remarkable because its symptoms strongly resemble normal human aging, but it occurs in young children. In most cases, it is not passed down through families. It is rarely seen in more than one child in a family. Symptoms Symptoms include:Growth failure during the first year of life Narrow, shrunken or wrinkled face Baldness BaldnessPartial or complete loss of hair is called alopecia.ImageRead Article Now Book Mark Article Loss of eyebrows and eyelashes Short stature Short statureA child who has short stature is much shorter than children who are the same age and sex. Your health care provider will go over your child's growth ...ImageRead Article Now Book Mark Article Large head for size of face (macrocephaly) MacrocephalyIncreased head circumference is when the measured distance around the widest part of the skull is larger than expected for the child's age and backgr...ImageRead Article Now Book Mark Article Open soft spot of the skull (fontanelle) Small jaw (micrognathia) MicrognathiaMicrognathia is a term for a lower jaw that is smaller than normal.ImageRead Article Now Book Mark Article Dry, scaly, thin skin Limited range of motion Limited range of motion Limited range of motion is a term meaning that a joint or body part cannot move through its normal range of motion.ImageRead Article Now Book Mark Article Teeth - delayed or absent formationTeeth - delayed or absent formationWhen a person's teeth grow in, they may be delayed or not occur at all.ImageRead Article Now Book Mark Article Exams and Tests Your health care provider will perform a physical exam and order laboratory tests. This may show:Insulin resistance Skin changes similar to that seen in scleroderma (the connective tissue becomes tough and hardened) Generally normal cholesterol and triglyceride levels Cardiac stress testing may reveal signs of early atherosclerosis of blood vessels.Genetic testing can detect changes in the gene (LMNA) that causes progeria. Treatment There is no specific treatment for progeria. Aspirin and statin medicines may be used to protect against a heart attack or stroke. Support Groups More information and support for people with Progeria and their families can be found at:Progeria Research Foundation, Inc. -- www.progeriaresearch.org Outlook (Prognosis) Progeria causes early death. People with the condition most often only live to their teenage years (average lifespan of 14 years). However, some can live into their early 20s. The cause of death is very often related to the heart or a stroke.StrokeA stroke occurs when blood flow to a part of the brain stops. A stroke is sometimes called a "brain attack. " If blood flow is cut off for longer th...ImageRead Article Now Book Mark Article Possible Complications Complications may include:Heart attack (myocardial infarction) Myocardial infarction)Most heart attacks are caused by a blood clot that blocks one of the coronary arteries. The coronary arteries bring blood and oxygen to the heart. ...ImageRead Article Now Book Mark Article Stroke When to Contact a Medical Professional Contact your provider if your child does not appear to be growing or developing normally.Open ReferencesReferencesGordon LB. Hutchinson-Gilford progeria syndrome (progeria). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 109.Jones KL, Jones MC, del Campo M. Senile-like appearance. In: Jones KL, Jones MC, del Campo M, eds. Smith's Recognizable Patterns of Human Malformation. 8th ed. Philadelphia, PA: Elsevier; 2022:174-197.National Center for Advancing Translational Sciences. Genetic and Rare Diseases Information Center website. Hutchinson-Gilford progeria syndrome. rarediseases.info.nih.gov/diseases/ 7467/hutchinson-gilford-progeria-syndrome. Updated February 2023. Accessed October 17, 2023.AllVideoImagesTogCoronary artery blockage - illustration Atherosclerosis is a common disorder of the arteries. Fat, cholesterol, and other substances collect in the walls of arteries. Larger accumulations are called atheromas or plaque and can damage artery walls and block blood flow. Severely restricted blood flow in the heart muscle leads to symptoms such as chest pain.Coronary artery blockageillustrationCoronary artery blockage - illustration Atherosclerosis is a common disorder of the arteries. Fat, cholesterol, and other substances collect in the walls of arteries. Larger accumulations are called atheromas or plaque and can damage artery walls and block blood flow. Severely restricted blood flow in the heart muscle leads to symptoms such as chest pain.Coronary artery blockageillustrationRelated Information Failure to thrive(Condition)Stroke(Condition)Heart attack(Condition)Stroke - InDepth(In-Depth)Heart attack and acute coronary syndrome - InDepth(In-Depth) Review Date: 9/18/2023 Reviewed By: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. 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ProgeriaHutchinson-Gilford progeria syndrome; HGPSProgeria is a rare genetic condition that produces rapid aging in children. Causes Progeria is a rare condition. It is remarkable because its symptoms strongly resemble normal human aging, but it occurs in young children. In most cases, it is not passed down through families. It is rarely seen in more than one child in a family. Symptoms Symptoms include:Growth failure during the first year of life Narrow, shrunken or wrinkled face Baldness BaldnessPartial or complete loss of hair is called alopecia.ImageRead Article Now Book Mark Article Loss of eyebrows and eyelashes Short stature Short statureA child who has short stature is much shorter than children who are the same age and sex. Your health care provider will go over your child's growth ...ImageRead Article Now Book Mark Article Large head for size of face (macrocephaly) MacrocephalyIncreased head circumference is when the measured distance around the widest part of the skull is larger than expected for the child's age and backgr...ImageRead Article Now Book Mark Article Open soft spot of the skull (fontanelle) Small jaw (micrognathia) MicrognathiaMicrognathia is a term for a lower jaw that is smaller than normal.ImageRead Article Now Book Mark Article Dry, scaly, thin skin Limited range of motion Limited range of motion Limited range of motion is a term meaning that a joint or body part cannot move through its normal range of motion.ImageRead Article Now Book Mark Article Teeth - delayed or absent formationTeeth - delayed or absent formationWhen a person's teeth grow in, they may be delayed or not occur at all.ImageRead Article Now Book Mark Article Exams and Tests Your health care provider will perform a physical exam and order laboratory tests. This may show:Insulin resistance Skin changes similar to that seen in scleroderma (the connective tissue becomes tough and hardened) Generally normal cholesterol and triglyceride levels Cardiac stress testing may reveal signs of early atherosclerosis of blood vessels.Genetic testing can detect changes in the gene (LMNA) that causes progeria. Treatment There is no specific treatment for progeria. Aspirin and statin medicines may be used to protect against a heart attack or stroke. Support Groups More information and support for people with Progeria and their families can be found at:Progeria Research Foundation, Inc. -- www.progeriaresearch.org Outlook (Prognosis) Progeria causes early death. People with the condition most often only live to their teenage years (average lifespan of 14 years). However, some can live into their early 20s. The cause of death is very often related to the heart or a stroke.StrokeA stroke occurs when blood flow to a part of the brain stops. A stroke is sometimes called a "brain attack. " If blood flow is cut off for longer th...ImageRead Article Now Book Mark Article Possible Complications Complications may include:Heart attack (myocardial infarction) Myocardial infarction)Most heart attacks are caused by a blood clot that blocks one of the coronary arteries. The coronary arteries bring blood and oxygen to the heart. ...ImageRead Article Now Book Mark Article Stroke When to Contact a Medical Professional Contact your provider if your child does not appear to be growing or developing normally.Open ReferencesReferencesGordon LB. Hutchinson-Gilford progeria syndrome (progeria). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 109.Jones KL, Jones MC, del Campo M. Senile-like appearance. In: Jones KL, Jones MC, del Campo M, eds. Smith's Recognizable Patterns of Human Malformation. 8th ed. Philadelphia, PA: Elsevier; 2022:174-197.National Center for Advancing Translational Sciences. Genetic and Rare Diseases Information Center website. Hutchinson-Gilford progeria syndrome. rarediseases.info.nih.gov/diseases/ 7467/hutchinson-gilford-progeria-syndrome. Updated February 2023. Accessed October 17, 2023.