BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuDermatitis herpetiformisDuhring disease; DHDermatitis herpetiformis (DH) is a very itchy rash consisting of bumps and blisters. The rash is chronic (long-term).BlistersA vesicle is a small fluid-filled blister on the skin.ImageRead Article Now Book Mark Article Causes DH usually begins in people age 20 and older. Children can sometimes be affected. It is seen in both men and women.The exact cause is unknown. Despite the name, it is not related to the herpes virus. DH is an autoimmune disorder. There is a strong link between DH and celiac disease. Celiac disease is an autoimmune disorder that causes inflammation in the small intestine from eating gluten. People with DH also have a sensitivity to gluten, which causes the skin rash. About 25% of people with celiac disease also have DH.Autoimmune disorderAn autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. There are more than 80 autoimmune d...ImageRead Article Now Book Mark Article Celiac diseaseCeliac disease is an autoimmune condition that damages the lining of the small intestine. This damage comes from a reaction to eating gluten. This ...ImageRead Article Now Book Mark Article Symptoms Symptoms include:Extremely itchy bumps or blisters, most often on the elbows, knees, back, and buttocks. Rashes that are usually the same size and shape on both sides. The rash can look like eczema. EczemaAtopic dermatitis is a long-term (chronic) skin disorder that involves scaly and itchy rashes. It is a type of eczema. Other forms of eczema include...ImageRead Article Now Book Mark Article Scratch marks and skin erosions instead of blisters in some people.Most people with DH have damage to their intestines from eating gluten. But only some have intestinal symptoms. Exams and Tests In most cases, a skin biopsy and direct immunofluorescence test of the skin are performed. The health care provider may also recommend a biopsy of the intestines. Blood tests may be ordered to support the diagnosis.Skin biopsyA skin lesion biopsy is when a small amount of skin is removed so it can be examined under a microscope. The skin is tested to look for skin conditi...ImageRead Article Now Book Mark Article BiopsyA biopsy is the removal of a small piece of tissue for laboratory examination.Read Article Now Book Mark Article Treatment An antibiotic called dapsone is very effective.A strict gluten-free diet will also be recommended to help control the disease. Sticking to this diet may eliminate the need for medicines and prevent later complications.Gluten-free dietCeliac disease is an immune disorder passed down through families. Gluten is a protein found in wheat, barley, or rye. It may also be found in some ...ImageRead Article Now Book Mark Article Medicines that suppress the immune system may be used, but are less effective. Outlook (Prognosis) The disease may be well-controlled with treatment. Without treatment, there may be a significant risk of intestinal cancer. Possible Complications Complications may include:Autoimmune thyroid disease Develop certain cancers, especially lymphomas of the intestines Side effects of the drugs used to treat DH When to Contact a Medical Professional Call your provider if you have a rash that continues despite treatment. Prevention There is no known prevention of this disease. People with this condition may be able to prevent complications by avoiding foods that contain gluten.Open ReferencesReferencesHull CM, Zone JJ. Dermatitis herpetiformis and linear IgA bullous dermatosis. In: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatology. 4th ed. Philadelphia, PA: Elsevier; 2018:chap 31.Lebwohl B, Green PHR. Celiac disease. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 107.AllVideoImagesTogDermatitis, herpetiformis - close-up of lesion - illustration Dermatitis herpetiformis is a chronic inflammatory disease that produces lesions that burn and itch intensely. This is a close-up of dermatitis herpetiformis lesions. The lesions are red (erythematous) and may be slightly raised (papular), form small pus-filled areas (pustules), or there may be blisters (vesicles). The disease develops suddenly and may last from weeks to months. It may occur in association with gluten (wheat) sensitivity and allergy.Dermatitis, herpetiformis - close-up of lesionillustrationDermatitis - herpetiformis on the knee - illustration This picture shows the knee of a person with a chronic inflammatory disease known as dermatitis herpetiformis. It produces red, raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases (such as Celiac disease).Dermatitis - herpetiformis on the kneeillustrationDermatitis - herpetiformis on the arm and legs - illustration This picture shows a chronic inflammatory disease (dermatitis herpetiformis) that produces red (erythematous), raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases (such as Celiac disease).Dermatitis - herpetiformis on the arm and legsillustrationDermatitis herpetiformis on the thumb - illustration This picture shows the thumb of a person with a chronic inflammatory disease known as dermatitis herpetiformis. It produces red, raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases such as celiac disease.Dermatitis herpetiformis on the thumbillustrationDermatitis herpetiformis on the hand - illustration This picture shows the fingers of a person with a chronic inflammatory disease known as dermatitis herpetiformis. It produces red, raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases such as celiac disease.Dermatitis herpetiformis on the handillustrationDermatitis herpetiformis on the forearm - illustration This picture shows the forearm of a person with a chronic inflammatory disease known as dermatitis herpetiformis. It produces red, raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases such as celiac disease.Dermatitis herpetiformis on the forearmillustrationDermatitis, herpetiformis - close-up of lesion - illustration Dermatitis herpetiformis is a chronic inflammatory disease that produces lesions that burn and itch intensely. This is a close-up of dermatitis herpetiformis lesions. The lesions are red (erythematous) and may be slightly raised (papular), form small pus-filled areas (pustules), or there may be blisters (vesicles). The disease develops suddenly and may last from weeks to months. It may occur in association with gluten (wheat) sensitivity and allergy.Dermatitis, herpetiformis - close-up of lesionillustrationDermatitis - herpetiformis on the knee - illustration This picture shows the knee of a person with a chronic inflammatory disease known as dermatitis herpetiformis. It produces red, raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases (such as Celiac disease).Dermatitis - herpetiformis on the kneeillustrationDermatitis - herpetiformis on the arm and legs - illustration This picture shows a chronic inflammatory disease (dermatitis herpetiformis) that produces red (erythematous), raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases (such as Celiac disease).Dermatitis - herpetiformis on the arm and legsillustrationDermatitis herpetiformis on the thumb - illustration This picture shows the thumb of a person with a chronic inflammatory disease known as dermatitis herpetiformis. It produces red, raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases such as celiac disease.Dermatitis herpetiformis on the thumbillustrationDermatitis herpetiformis on the hand - illustration This picture shows the fingers of a person with a chronic inflammatory disease known as dermatitis herpetiformis. It produces red, raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases such as celiac disease.Dermatitis herpetiformis on the handillustrationDermatitis herpetiformis on the forearm - illustration This picture shows the forearm of a person with a chronic inflammatory disease known as dermatitis herpetiformis. It produces red, raised (papular), small or large blisters (vesicles or bullae) that burn and itch intensely. Dermatitis herpetiformis develops suddenly, lasts for weeks to months, and may be associated with digestive diseases such as celiac disease.Dermatitis herpetiformis on the forearmillustrationRelated Information Review Date: 6/7/2023 Reviewed By: Elika Hoss, MD, Assistant Professor of Dermatology, Mayo Clinic, Scottsdale, AZ. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited. © 1997- All rights reserved. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.Content is best viewed in IE9 or above, Firefox and Google Chrome browser.
Dermatitis herpetiformisDuhring disease; DHDermatitis herpetiformis (DH) is a very itchy rash consisting of bumps and blisters. The rash is chronic (long-term).BlistersA vesicle is a small fluid-filled blister on the skin.ImageRead Article Now Book Mark Article Causes DH usually begins in people age 20 and older. Children can sometimes be affected. It is seen in both men and women.The exact cause is unknown. Despite the name, it is not related to the herpes virus. DH is an autoimmune disorder. There is a strong link between DH and celiac disease. Celiac disease is an autoimmune disorder that causes inflammation in the small intestine from eating gluten. People with DH also have a sensitivity to gluten, which causes the skin rash. About 25% of people with celiac disease also have DH.Autoimmune disorderAn autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. There are more than 80 autoimmune d...ImageRead Article Now Book Mark Article Celiac diseaseCeliac disease is an autoimmune condition that damages the lining of the small intestine. This damage comes from a reaction to eating gluten. This ...ImageRead Article Now Book Mark Article Symptoms Symptoms include:Extremely itchy bumps or blisters, most often on the elbows, knees, back, and buttocks. Rashes that are usually the same size and shape on both sides. The rash can look like eczema. EczemaAtopic dermatitis is a long-term (chronic) skin disorder that involves scaly and itchy rashes. It is a type of eczema. Other forms of eczema include...ImageRead Article Now Book Mark Article Scratch marks and skin erosions instead of blisters in some people.Most people with DH have damage to their intestines from eating gluten. But only some have intestinal symptoms. Exams and Tests In most cases, a skin biopsy and direct immunofluorescence test of the skin are performed. The health care provider may also recommend a biopsy of the intestines. Blood tests may be ordered to support the diagnosis.Skin biopsyA skin lesion biopsy is when a small amount of skin is removed so it can be examined under a microscope. The skin is tested to look for skin conditi...ImageRead Article Now Book Mark Article BiopsyA biopsy is the removal of a small piece of tissue for laboratory examination.Read Article Now Book Mark Article Treatment An antibiotic called dapsone is very effective.A strict gluten-free diet will also be recommended to help control the disease. Sticking to this diet may eliminate the need for medicines and prevent later complications.Gluten-free dietCeliac disease is an immune disorder passed down through families. Gluten is a protein found in wheat, barley, or rye. It may also be found in some ...ImageRead Article Now Book Mark Article Medicines that suppress the immune system may be used, but are less effective. Outlook (Prognosis) The disease may be well-controlled with treatment. Without treatment, there may be a significant risk of intestinal cancer. Possible Complications Complications may include:Autoimmune thyroid disease Develop certain cancers, especially lymphomas of the intestines Side effects of the drugs used to treat DH When to Contact a Medical Professional Call your provider if you have a rash that continues despite treatment. Prevention There is no known prevention of this disease. People with this condition may be able to prevent complications by avoiding foods that contain gluten.Open ReferencesReferencesHull CM, Zone JJ. Dermatitis herpetiformis and linear IgA bullous dermatosis. In: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatology. 4th ed. Philadelphia, PA: Elsevier; 2018:chap 31.Lebwohl B, Green PHR. Celiac disease. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 107.