BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuFibrous dysplasiaInflammatory fibrous hyperplasia; Idiopathic fibrous hyperplasia; McCune-Albright syndromeFibrous dysplasia is a bone disease that destroys and replaces normal bone with fibrous bone tissue. One or more bones can be affected. Causes Fibrous dysplasia usually occurs in childhood. Most people have symptoms by the time they are 30 years old. The disease occurs more often in females.Fibrous dysplasia is linked to a problem with genes (gene mutation) that control bone-producing cells. The mutation occurs when a baby is developing in the womb. The condition is not passed from parent to child. Symptoms Symptoms may include any of the following:Bone pain Bone sores (lesions) Hormone (endocrine gland) problems Fractures or bone deformities Unusual skin color (pigmentation), which occurs with McCune-Albright syndromeMcCune-Albright syndromeMcCune-Albright syndrome is a genetic disease that affects the bones, hormones, and color (pigmentation) of the skin.ImageRead Article Now Book Mark Article The bone lesions may stop when the child reaches puberty. Exams and Tests Your health care provider will perform a physical examination. X-rays of bones are taken. An MRI may be recommended. Treatment There is no cure for fibrous dysplasia. Bone fractures or deformities are treated as needed. Hormone problems will need to be treated. Outlook (Prognosis) The outlook depends on the severity of the condition and the symptoms that occur. Possible Complications Depending on the bones that are affected, health problems that may result include:If skull bone is affected, there can be vision or hearing loss If a leg bone is affected, there can be difficulty walking and joint problems such as arthritisArthritisArthritis is inflammation or degeneration of one or more joints. A joint is the area where 2 bones meet. There are more than 100 different types of...ImageRead Article Now Book Mark Article When to Contact a Medical Professional Contact your provider if your child has symptoms of this condition, such as repeated bone fractures and unexplained bone deformity.Specialists in orthopedics, endocrinology, and genetics may be involved in your child's diagnosis and care. Prevention There is no known way to prevent fibrous dysplasia. Treatment aims to prevent complications, such as recurrent bone fractures, to help make the condition less severe.Open ReferencesReferencesNadol JB, Quesnel AM. Otologic manifestations of systemic disease. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 151.Nicolai P, Mattavelli D, Castlenuovo P. Benign tumors of the sinonasal tract. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 50.Shiflett JM, Caroll BW. Skull lesions in children. In: Winn HR, ed. Youmans and Winn Neurological Surgery. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 245.Toy PC, Heck RK. Benign bone tumors and nonneoplastic conditions simulating bone tumors. In: Azar FM, Beaty JH, eds. Campbell's Operative Orthopaedics. 14th ed. Philadelphia, PA: Elsevier; 2021:chap 25.AllVideoImagesTogAnterior skeletal anatomy - illustration The skeleton is made up of 206 bones in the adult and contributes to the form and shape of the body. The skeleton has several important functions for the body. The bones of the skeleton provide support for the soft tissues. For example, the rib cage supports the thoracic wall. Most muscles of the body are attached to bones which act as levers to allow movement of body parts. The bones of the skeleton also serve as a reservoir for minerals, such as calcium and phosphate. Finally, most of the blood cell formation takes places within the marrow of certain bones.Anterior skeletal anatomyillustrationAnterior skeletal anatomy - illustration The skeleton is made up of 206 bones in the adult and contributes to the form and shape of the body. The skeleton has several important functions for the body. The bones of the skeleton provide support for the soft tissues. For example, the rib cage supports the thoracic wall. Most muscles of the body are attached to bones which act as levers to allow movement of body parts. The bones of the skeleton also serve as a reservoir for minerals, such as calcium and phosphate. Finally, most of the blood cell formation takes places within the marrow of certain bones.Anterior skeletal anatomyillustrationRelated Information McCune-Albright syndrome(Condition)Endocrine glands(Special Topic)Rickets(Condition)Gigantism(Condition)Acromegaly(Condition)Cushing disease(Condition)Hyperthyroidism(Condition) Review Date: 11/6/2023 Reviewed By: Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. 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Fibrous dysplasiaInflammatory fibrous hyperplasia; Idiopathic fibrous hyperplasia; McCune-Albright syndromeFibrous dysplasia is a bone disease that destroys and replaces normal bone with fibrous bone tissue. One or more bones can be affected. Causes Fibrous dysplasia usually occurs in childhood. Most people have symptoms by the time they are 30 years old. The disease occurs more often in females.Fibrous dysplasia is linked to a problem with genes (gene mutation) that control bone-producing cells. The mutation occurs when a baby is developing in the womb. The condition is not passed from parent to child. Symptoms Symptoms may include any of the following:Bone pain Bone sores (lesions) Hormone (endocrine gland) problems Fractures or bone deformities Unusual skin color (pigmentation), which occurs with McCune-Albright syndromeMcCune-Albright syndromeMcCune-Albright syndrome is a genetic disease that affects the bones, hormones, and color (pigmentation) of the skin.ImageRead Article Now Book Mark Article The bone lesions may stop when the child reaches puberty. Exams and Tests Your health care provider will perform a physical examination. X-rays of bones are taken. An MRI may be recommended. Treatment There is no cure for fibrous dysplasia. Bone fractures or deformities are treated as needed. Hormone problems will need to be treated. Outlook (Prognosis) The outlook depends on the severity of the condition and the symptoms that occur. Possible Complications Depending on the bones that are affected, health problems that may result include:If skull bone is affected, there can be vision or hearing loss If a leg bone is affected, there can be difficulty walking and joint problems such as arthritisArthritisArthritis is inflammation or degeneration of one or more joints. A joint is the area where 2 bones meet. There are more than 100 different types of...ImageRead Article Now Book Mark Article When to Contact a Medical Professional Contact your provider if your child has symptoms of this condition, such as repeated bone fractures and unexplained bone deformity.Specialists in orthopedics, endocrinology, and genetics may be involved in your child's diagnosis and care. Prevention There is no known way to prevent fibrous dysplasia. Treatment aims to prevent complications, such as recurrent bone fractures, to help make the condition less severe.Open ReferencesReferencesNadol JB, Quesnel AM. Otologic manifestations of systemic disease. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 151.Nicolai P, Mattavelli D, Castlenuovo P. Benign tumors of the sinonasal tract. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 50.Shiflett JM, Caroll BW. Skull lesions in children. In: Winn HR, ed. Youmans and Winn Neurological Surgery. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 245.Toy PC, Heck RK. Benign bone tumors and nonneoplastic conditions simulating bone tumors. In: Azar FM, Beaty JH, eds. Campbell's Operative Orthopaedics. 14th ed. Philadelphia, PA: Elsevier; 2021:chap 25.