BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuMacroamylasemiaMacroamylasemia is the presence of an abnormal substance called macroamylase in the blood. Causes Macroamylase is a substance that consists of an enzyme, called amylase, attached to a protein. Because it is large, macroamylase is filtered very slowly from the blood by the kidneys.EnzymeEnzymes are complex proteins that cause a specific chemical change. For example, they can help break down the foods we eat so the body can use them....Read Article Now Book Mark Article Most people with macroamylasemia do not have a serious disease that is causing it, but the condition has been associated with:Celiac disease Celiac diseaseCeliac disease is an autoimmune condition that damages the lining of the small intestine. This damage comes from a reaction to eating gluten. This ...Read Article Now Book Mark Article Lymphoma HIV infection Monoclonal gammopathy Rheumatoid arthritis Rheumatoid arthritisRheumatoid arthritis (RA) is a disease that leads to inflammation of the joints and surrounding tissues. It is a long-term disease. It can also aff...Read Article Now Book Mark Article Ulcerative colitisUlcerative colitisUlcerative colitis is a condition in which the lining of the large intestine (colon) and rectum become inflamed. It is a form of inflammatory bowel ...Read Article Now Book Mark Article Symptoms Macroamylasemia does not cause symptoms. Exams and Tests A blood test will show high levels of amylase. However, macroamylasemia can cause test results similar to acute pancreatitis, which also causes high levels of amylase in the blood.Acute pancreatitisAcute pancreatitis is sudden swelling and inflammation of the pancreas.Read Article Now Book Mark Article Measuring amylase levels in the urine can help tell macroamylasemia apart from acute pancreatitis. Urine levels of amylase are low in people with macroamylasemia, but high in people with acute pancreatitis. Other tests such as the polyethylene glycol (PEG) precipitation assay are sometimes done to confirm the diagnosis.Open ReferencesReferencesForsmark CE. Pancreatitis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 130.Siddiqi HA, Rabinowitz S, Axiotis CA. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 23.Vege SS. Acute pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 58.AllVideoImagesTogRelated Information Review Date: 12/31/2023 Reviewed By: Jenifer K. Lehrer, MD, Department of Gastroenterology, Aria - Jefferson Health Torresdale, Jefferson Digestive Diseases Network, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited. © 1997- All rights reserved. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.Content is best viewed in IE9 or above, Firefox and Google Chrome browser.
MacroamylasemiaMacroamylasemia is the presence of an abnormal substance called macroamylase in the blood. Causes Macroamylase is a substance that consists of an enzyme, called amylase, attached to a protein. Because it is large, macroamylase is filtered very slowly from the blood by the kidneys.EnzymeEnzymes are complex proteins that cause a specific chemical change. For example, they can help break down the foods we eat so the body can use them....Read Article Now Book Mark Article Most people with macroamylasemia do not have a serious disease that is causing it, but the condition has been associated with:Celiac disease Celiac diseaseCeliac disease is an autoimmune condition that damages the lining of the small intestine. This damage comes from a reaction to eating gluten. This ...Read Article Now Book Mark Article Lymphoma HIV infection Monoclonal gammopathy Rheumatoid arthritis Rheumatoid arthritisRheumatoid arthritis (RA) is a disease that leads to inflammation of the joints and surrounding tissues. It is a long-term disease. It can also aff...Read Article Now Book Mark Article Ulcerative colitisUlcerative colitisUlcerative colitis is a condition in which the lining of the large intestine (colon) and rectum become inflamed. It is a form of inflammatory bowel ...Read Article Now Book Mark Article Symptoms Macroamylasemia does not cause symptoms. Exams and Tests A blood test will show high levels of amylase. However, macroamylasemia can cause test results similar to acute pancreatitis, which also causes high levels of amylase in the blood.Acute pancreatitisAcute pancreatitis is sudden swelling and inflammation of the pancreas.Read Article Now Book Mark Article Measuring amylase levels in the urine can help tell macroamylasemia apart from acute pancreatitis. Urine levels of amylase are low in people with macroamylasemia, but high in people with acute pancreatitis. Other tests such as the polyethylene glycol (PEG) precipitation assay are sometimes done to confirm the diagnosis.Open ReferencesReferencesForsmark CE. Pancreatitis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 130.Siddiqi HA, Rabinowitz S, Axiotis CA. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 23.Vege SS. Acute pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 58.