BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuSertoli-Leydig cell tumorSertoli-stromal cell tumor; Arrhenoblastoma; Androblastoma; Ovarian cancer - Sertoli-Leydig cell tumorSertoli-Leydig cell tumor (SLCT) is a rare cancer of the ovaries. The cancer cells produce and release a male sex hormone called testosterone. Causes The exact cause of this tumor is not known. Changes (mutations) in genes may play a role.SLCT occur most often in young women 20 to 30 years old. But the tumor can occur at any age. Symptoms The Sertoli cells are normally located in the male reproductive glands (the testes). They feed sperm cells. The Leydig cells, also located in the testes, release a male sex hormone.These cells are also found in a woman's ovaries, and in very rare cases lead to cancer. SLCT starts in the female ovaries, mostly in one ovary. The cancer cells release a male sex hormone. As a result, the woman may develop symptoms such as:A deep voice Enlarged clitoris Facial hair Facial hairMost of the time, women have fine hair above their lips and on their chin, chest, abdomen, or back. The growth of coarse dark hair in these areas (m...Read Article Now Book Mark Article Loss in breast size Stopping of menstrual periodsPain in the lower belly (pelvic area) is another symptom. It occurs due to the tumor pressing on nearby structures. Exams and Tests The health care provider will perform a physical exam and a pelvic exam, and ask about the symptoms.Tests will be ordered to check the levels of female and male hormones, including testosterone.TestosteroneA testosterone test measures the amount of the male hormone, testosterone, in the blood. Both men and women produce this hormone. The test described...Read Article Now Book Mark Article An ultrasound or CT scan will likely be done to find out where the tumor is and its size and shape.UltrasoundA pelvic (transabdominal) ultrasound is an imaging test. It is used to examine organs in the pelvis.Read Article Now Book Mark Article Treatment Surgery is done to remove one or both ovaries.If the tumor is advanced stage, chemotherapy or radiation therapy may be done after surgery.ChemotherapyThe term chemotherapy is used to describe cancer-killing drugs. Chemotherapy may be used to:Cure the cancerShrink the cancerPrevent the cancer from ...ImageRead Article Now Book Mark Article Radiation therapyRadiation therapy uses high-powered radiation (such as x-rays or gamma rays), particles, or radioactive seeds to kill cancer cells.ImageRead Article Now Book Mark Article Outlook (Prognosis) Early treatment results in a good outcome. Feminine characteristics usually return after surgery. But male characteristics resolve more slowly.For more advanced stage tumors, outlook is less positive.Open ReferencesReferencesFletcher CDM. Tumors of the female genital tract. In: Fletcher CDM, ed. Diagnostic Histopathology of Tumors. 5th ed. Philadelphia, PA: Elsevier; 2021:chap 13.Penick ER, Hamilton CA, Maxwell GL, Marcus CS. Germ cell, stromal, and other ovarian tumors. In: DiSaia PJ, Creasman WT, Mannel RS, McMeekin DS, Mutch DG, eds. Clinical Gynecologic Oncology. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 12.Smith RP. Sertoli-Leydig cell tumor (arrhenoblastoma). In: Smith RP, ed. Netter's Obstetrics & Gynecology. 3rd ed. Philadelphia, PA: Elsevier; 2018:chap 158.AllVideoImagesTogMale reproductive system - illustration The male reproductive system, viewed from a sagittal section.Male reproductive systemillustrationMale reproductive system - illustration The male reproductive system, viewed from a sagittal section.Male reproductive systemillustrationRelated Information Testosterone(Medical Test)Ovarian cancer(Condition)Virilization(Special Topic)Ovarian cancer - InDepth(In-Depth) Review Date: 4/29/2022 Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. 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Sertoli-Leydig cell tumorSertoli-stromal cell tumor; Arrhenoblastoma; Androblastoma; Ovarian cancer - Sertoli-Leydig cell tumorSertoli-Leydig cell tumor (SLCT) is a rare cancer of the ovaries. The cancer cells produce and release a male sex hormone called testosterone. Causes The exact cause of this tumor is not known. Changes (mutations) in genes may play a role.SLCT occur most often in young women 20 to 30 years old. But the tumor can occur at any age. Symptoms The Sertoli cells are normally located in the male reproductive glands (the testes). They feed sperm cells. The Leydig cells, also located in the testes, release a male sex hormone.These cells are also found in a woman's ovaries, and in very rare cases lead to cancer. SLCT starts in the female ovaries, mostly in one ovary. The cancer cells release a male sex hormone. As a result, the woman may develop symptoms such as:A deep voice Enlarged clitoris Facial hair Facial hairMost of the time, women have fine hair above their lips and on their chin, chest, abdomen, or back. The growth of coarse dark hair in these areas (m...Read Article Now Book Mark Article Loss in breast size Stopping of menstrual periodsPain in the lower belly (pelvic area) is another symptom. It occurs due to the tumor pressing on nearby structures. Exams and Tests The health care provider will perform a physical exam and a pelvic exam, and ask about the symptoms.Tests will be ordered to check the levels of female and male hormones, including testosterone.TestosteroneA testosterone test measures the amount of the male hormone, testosterone, in the blood. Both men and women produce this hormone. The test described...Read Article Now Book Mark Article An ultrasound or CT scan will likely be done to find out where the tumor is and its size and shape.UltrasoundA pelvic (transabdominal) ultrasound is an imaging test. It is used to examine organs in the pelvis.Read Article Now Book Mark Article Treatment Surgery is done to remove one or both ovaries.If the tumor is advanced stage, chemotherapy or radiation therapy may be done after surgery.ChemotherapyThe term chemotherapy is used to describe cancer-killing drugs. Chemotherapy may be used to:Cure the cancerShrink the cancerPrevent the cancer from ...ImageRead Article Now Book Mark Article Radiation therapyRadiation therapy uses high-powered radiation (such as x-rays or gamma rays), particles, or radioactive seeds to kill cancer cells.ImageRead Article Now Book Mark Article Outlook (Prognosis) Early treatment results in a good outcome. Feminine characteristics usually return after surgery. But male characteristics resolve more slowly.For more advanced stage tumors, outlook is less positive.Open ReferencesReferencesFletcher CDM. Tumors of the female genital tract. In: Fletcher CDM, ed. Diagnostic Histopathology of Tumors. 5th ed. Philadelphia, PA: Elsevier; 2021:chap 13.Penick ER, Hamilton CA, Maxwell GL, Marcus CS. Germ cell, stromal, and other ovarian tumors. In: DiSaia PJ, Creasman WT, Mannel RS, McMeekin DS, Mutch DG, eds. Clinical Gynecologic Oncology. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 12.Smith RP. Sertoli-Leydig cell tumor (arrhenoblastoma). In: Smith RP, ed. Netter's Obstetrics & Gynecology. 3rd ed. Philadelphia, PA: Elsevier; 2018:chap 158.